ID A0A1P7U1M6_EBVA8 Unreviewed; 364 AA. AC A0A1P7U1M6; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 22-FEB-2023, entry version 15. DE RecName: Full=Triplex capsid protein 1 {ECO:0000256|HAMAP-Rule:MF_04018}; GN Name=TRX1 {ECO:0000256|HAMAP-Rule:MF_04018}; OS Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4). OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; OC Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus. OX NCBI_TaxID=82830 {ECO:0000313|EMBL:ABB89231.1, ECO:0000313|Proteomes:UP000007639}; OH NCBI_TaxID=9606; Homo sapiens (Human). RN [1] {ECO:0000313|Proteomes:UP000007639} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AG876 {ECO:0000313|Proteomes:UP000007639}; RX PubMed=6087149; DOI=10.1038/310207a0; RA Baer R.J., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J., RA Gibson T.J., Hatfull G.F., Hudson G.S., Satchwell S.C., Seguin C., RA Tuffnell P.S., Barrell B.G.; RT "DNA sequence and expression of the B95-8 Epstein-Barr virus genome."; RL Nature 310:207-211(1984). RN [2] {ECO:0000313|Proteomes:UP000007639} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AG876 {ECO:0000313|Proteomes:UP000007639}; RX PubMed=8393237; DOI=10.1006/viro.1993.1409; RA Lees J.F., Arrand J.E., Pepper S.D., Stewart J.P., Mackett M., Arrand J.R.; RT "The Epstein-Barr virus candidate vaccine antigen gp340/220 is highly RT conserved between virus types A and B."; RL Virology 195:578-586(1993). RN [3] {ECO:0000313|EMBL:ABB89231.1, ECO:0000313|Proteomes:UP000007639} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AG876 {ECO:0000313|EMBL:ABB89231.1, RC ECO:0000313|Proteomes:UP000007639}; RX PubMed=16490228; DOI=10.1016/j.virol.2006.01.015; RA Dolan A., Addison C., Gatherer D., Davison A.J., McGeoch D.J.; RT "The genome of Epstein-Barr virus type 2 strain AG876."; RL Virology 350:164-170(2006). CC -!- FUNCTION: Structural component of the T=16 icosahedral capsid. The CC capsid is composed of pentamers and hexamers of major capsid CC protein/MCP, which are linked together by heterotrimers called CC triplexes. These triplexes are formed by a single molecule of triplex CC protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, CC TRX1 is required for efficient transport of TRX2 to the nucleus, which CC is the site of capsid assembly. {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SUBUNIT: Interacts with TRX2, MCP and capsid vertex component 2/CVC2. CC {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|HAMAP-Rule:MF_04018}. Host CC nucleus {ECO:0000256|HAMAP-Rule:MF_04018}. CC -!- SIMILARITY: Belongs to the herpesviridae TRX1 protein family. CC {ECO:0000256|HAMAP-Rule:MF_04018}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ279927; ABB89231.1; -; Genomic_DNA. DR RefSeq; YP_001129451.1; NC_009334.1. DR GeneID; 5176167; -. DR KEGG; vg:5176167; -. DR Proteomes; UP000007639; Genome. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0019069; P:viral capsid assembly; IEA:UniProtKB-UniRule. DR HAMAP; MF_04018; HSV_TRX1; 1. DR InterPro; IPR004999; Herpes_1. DR Pfam; PF03327; Herpes_VP19C; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|HAMAP-Rule:MF_04018}; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04018}; KW Reference proteome {ECO:0000313|Proteomes:UP000007639}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04018}. SQ SEQUENCE 364 AA; 39149 MW; C843A9B1A0C16152 CRC64; MKVQGSVDRR RLQRRIAGLL PPPARRLNIS RGSEFTRDVR GLVEEHAQAS SLSAAAVWRA GLLAPGEVAV AGGGSGGGSF SWSGWRPPVF GDFLIHASSF NNAEATGTPL FQFKQSDPFS GVDAVFTPLS LFILMNHGRG VAARVEAGGG LTRMANLLYD SPATLADLVP DFGRLVADRR FHNFITPVGP LVENIKSTYL NKITTVVHGP VVSKAIPRST VKVTVPQEAF VDLDAWLSGG AGGGGGGCFV GGLGLQPCPA DARLYVALTY EEAGPRFTFF QSSRGHCQIM NILRIYYSPS IMHRYAVVQP LHIEELTFGA VACLGTFSAT DGWRRSAFNY RGSSLPVVEI DSFYSNVSDW EVIL //