ID A0A1N7SYA5_HUMAN Unreviewed; 258 AA. AC A0A1N7SYA5; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 24-JUL-2024, entry version 36. DE SubName: Full=HLA class II histocompatibility antigen DP beta chain {ECO:0000313|EMBL:BBD34244.1}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:SIT60270.1}; GN Name=HLA-DPB1 {ECO:0000313|EMBL:SIT60270.1}; GN Synonyms=DPB1 {ECO:0000313|EMBL:QBH69648.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:SIT60270.1}; RN [1] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Song W.-J., Kurnit D.M.; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Lang K., Schoefl G., Schmidt A., Lange V.; RT "Complementing the HLA-DPB1 Database: Full-Length Gene Characterization of RT all Common and Well-Documented Alleles."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:SJK83301.1} RP NUCLEOTIDE SEQUENCE. RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:BBD34244.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30337930; DOI=.3389/fimmu.2018.02294; RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A., RA Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S., RA Morishima Y., Inoko H., Kulski J.K., Shiina T.; RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class RT I and II Genes With Short-Read Sequencing on the ION PGM System and Long- RT Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio RT Platform."; RL Front. Immunol. 9:2294-2294(2018). RN [5] {ECO:0000313|EMBL:QBH69648.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Enczmann J., Fischer J.; RT "Novel HLA-DPB1 alleles."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC257926; BBD34244.1; -; Genomic_DNA. DR EMBL; MH507367; QBH69648.1; -; Genomic_DNA. DR EMBL; LT707771; SIT60270.1; -; Genomic_DNA. DR EMBL; LT707772; SIT60271.1; -; Genomic_DNA. DR EMBL; LT718986; SJK83301.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1N7SYA5; -. DR SMR; A0A1N7SYA5; -. DR PeptideAtlas; A0A1N7SYA5; -. DR ChiTaRS; HLA-DPB1; human. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR CDD; cd21003; IgC1_MHC_II_beta_HLA-DP; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR050160; MHC/Immunoglobulin. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF46; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..258 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015068155" FT TRANSMEM 227..246 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 124..212 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 258 AA; 29316 MW; 17670963C0A21C69 CRC64; MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN REEFVRFDSD VGEFRAVTEL GRPEAEYWNS QKDILEEERA VPDRICRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFMLGLIIC GVGIFMHRRS KKVQRGSA //