ID A0A1N7SYA5_HUMAN Unreviewed; 258 AA. AC A0A1N7SYA5; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 03-JUL-2019, entry version 21. DE SubName: Full=HLA class II histocompatibility antigen DP beta chain {ECO:0000313|EMBL:BBD34244.1}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:SIT60270.1}; GN Name=HLA-DPB1 {ECO:0000313|EMBL:SIT60270.1}; GN Synonyms=DPB1 {ECO:0000313|EMBL:QBH69648.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:SIT60270.1}; RN [1] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Song W.-J., Kurnit D.M.; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Lang K., Schoefl G., Schmidt A., Lange V.; RT "Complementing the HLA-DPB1 Database: Full-Length Gene RT Characterization of all Common and Well-Documented Alleles."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:SJK83301.1} RP NUCLEOTIDE SEQUENCE. RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:BBD34244.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30337930; DOI=.3389/fimmu.2018.02294; RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., RA Oka A., Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., RA Morishima S., Morishima Y., Inoko H., Kulski J.K., Shiina T.; RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA RT Class I and II Genes With Short-Read Sequencing on the ION PGM System RT and Long-Reads Generated by Single Molecule, Real-Time Sequencing on RT the PacBio Platform."; RL Front. Immunol. 9:2294-2294(2018). RN [5] {ECO:0000313|EMBL:QBH69648.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Enczmann J., Fischer J.; RT "Novel HLA-DPB1 alleles."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class II family. CC {ECO:0000256|SAAS:SAAS00552561}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC257926; BBD34244.1; -; Genomic_DNA. DR EMBL; MH507367; QBH69648.1; -; Genomic_DNA. DR EMBL; LT707771; SIT60270.1; -; Genomic_DNA. DR EMBL; LT707772; SIT60271.1; -; Genomic_DNA. DR EMBL; LT718986; SJK83301.1; -; Genomic_DNA. DR ChiTaRS; HLA-DPB1; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.10.320.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Adaptive immunity {ECO:0000256|SAAS:SAAS01191061}; KW Disulfide bond {ECO:0000256|SAAS:SAAS00298785}; KW Immunity {ECO:0000256|SAAS:SAAS00288599}; KW Membrane {ECO:0000256|SAAS:SAAS00288628, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|SAAS:SAAS00288621}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00288613, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00288610, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 258 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5015068155. FT TRANSMEM 227 246 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 124 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 258 AA; 29316 MW; 17670963C0A21C69 CRC64; MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN REEFVRFDSD VGEFRAVTEL GRPEAEYWNS QKDILEEERA VPDRICRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFMLGLIIC GVGIFMHRRS KKVQRGSA //