ID A0A1N7SYA5_HUMAN Unreviewed; 258 AA. AC A0A1N7SYA5; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 20-DEC-2017, entry version 10. DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:SIT60270.1}; GN Name=HLA-DPB1 {ECO:0000313|EMBL:SIT60270.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:SIT60270.1}; RN [1] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Song W.-J., Kurnit D.M.; RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SIT60270.1} RP NUCLEOTIDE SEQUENCE. RA Lang K., Schoefl G., Schmidt A., Lange V.; RT "Complementing the HLA-DPB1 Database: Full-Length Gene RT Characterization of all Common and Well-Documented Alleles."; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:SJK83301.1} RP NUCLEOTIDE SEQUENCE. RA Mah S.A., Swanson W.J., Moy G.W., Vacquier V.D.; RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class II family. CC {ECO:0000256|SAAS:SAAS00552561}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LT707771; SIT60270.1; -; Genomic_DNA. DR EMBL; LT707772; SIT60271.1; -; Genomic_DNA. DR EMBL; LT718986; SJK83301.1; -; Genomic_DNA. DR UniGene; Hs.485130; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 1. DR Gene3D; 3.10.320.10; -; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR ProDom; PD000328; MHC_II_b_N; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; SSF48726; 1. DR SUPFAM; SSF54452; SSF54452; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00465899}; KW Immunity {ECO:0000256|SAAS:SAAS00437908}; KW Membrane {ECO:0000256|SAAS:SAAS00437963, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|SAAS:SAAS00437896}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00437939, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00437953, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 29 {ECO:0000256|SAM:SignalP}. FT CHAIN 30 258 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5011396875. FT TRANSMEM 227 246 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 124 212 Ig-like. {ECO:0000259|PROSITE:PS50835}. SQ SEQUENCE 258 AA; 29316 MW; 17670963C0A21C69 CRC64; MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN REEFVRFDSD VGEFRAVTEL GRPEAEYWNS QKDILEEERA VPDRICRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFMLGLIIC GVGIFMHRRS KKVQRGSA //