ID A0A1N6LX74_BABMR Unreviewed; 418 AA. AC A0A1N6LX74; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 27-NOV-2024, entry version 19. DE RecName: Full=Translation initiation factor eIF2B subunit gamma {ECO:0000256|ARBA:ARBA00044196}; DE AltName: Full=eIF2B GDP-GTP exchange factor subunit gamma {ECO:0000256|ARBA:ARBA00044229}; GN ORFNames=BMR1_01G03400 {ECO:0000313|EMBL:SIO73478.1}; OS Babesia microti (strain RI). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida; OC Babesiidae; Babesia. OX NCBI_TaxID=1133968 {ECO:0000313|EMBL:SIO73478.1, ECO:0000313|Proteomes:UP000002899}; RN [1] {ECO:0000313|EMBL:SIO73478.1, ECO:0000313|Proteomes:UP000002899} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RI {ECO:0000313|EMBL:SIO73478.1, RC ECO:0000313|Proteomes:UP000002899}; RX PubMed=22833609; DOI=10.1093/nar/gks700; RA Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V., RA Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B., RA Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H., RA Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T., RA Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V., RA Ben Mamoun C.; RT "Sequencing of the smallest Apicomplexan genome from the human pathogen RT Babesia microti."; RL Nucleic Acids Res. 40:9102-9114(2012). CC -!- FUNCTION: Acts as a component of the translation initiation factor 2B CC (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the CC eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its CC guanine nucleotide exchange factor activity is repressed when bound to CC eIF2 complex phosphorylated on the alpha subunit, thereby limiting the CC amount of methionyl-initiator methionine tRNA available to the ribosome CC and consequently global translation is repressed. CC {ECO:0000256|ARBA:ARBA00045373}. CC -!- SUBUNIT: Component of the translation initiation factor 2B (eIF2B) CC complex which is a heterodecamer of two sets of five different CC subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta CC and delta comprise a regulatory subcomplex and subunits epsilon and CC gamma comprise a catalytic subcomplex. Within the complex, the CC hexameric regulatory complex resides at the center, with the two CC heterodimeric catalytic subcomplexes bound on opposite sides. CC {ECO:0000256|ARBA:ARBA00046432}. CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol CC {ECO:0000256|ARBA:ARBA00004514}. CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family. CC {ECO:0000256|ARBA:ARBA00007878}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO082871; SIO73478.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1N6LX74; -. DR VEuPathDB; PiroplasmaDB:BMR1_01G03400; -. DR OrthoDB; 161736at2759; -. DR Proteomes; UP000002899; Chromosome I. DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. DR GO; GO:0005851; C:eukaryotic translation initiation factor 2B complex; IEA:TreeGrafter. DR GO; GO:0032045; C:guanyl-nucleotide exchange factor complex; IEA:TreeGrafter. DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:TreeGrafter. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR GO; GO:0002183; P:cytoplasmic translational initiation; IEA:TreeGrafter. DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1. DR InterPro; IPR051960; eIF2B_gamma. DR InterPro; IPR005835; NTP_transferase_dom. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR PANTHER; PTHR45989; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1. DR PANTHER; PTHR45989:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1. DR Pfam; PF00483; NTP_transferase; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 3: Inferred from homology; KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, KW ECO:0000313|EMBL:SIO73478.1}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}; KW Reference proteome {ECO:0000313|Proteomes:UP000002899}. FT DOMAIN 23..161 FT /note="Nucleotidyl transferase" FT /evidence="ECO:0000259|Pfam:PF00483" SQ SEQUENCE 418 AA; 46619 MW; 54F1D6E30424C28E CRC64; MSPPSSDHGD SIAEHHDTSK IQGIILASNS TFNISILTAE HSKALLSING KPLIWHSIKL LTDNGIKDIF VVIEPKYKPA LEAAFKDFID AVTVTIISLD AEVLGSLDAL KFLREYITND FIVIPCDIYG KVDITGLIKS HYQSHSGCTA LLYHNEKDTS NSYRCLTLLD EATHKLISIV DSTSFNAGNS LFIHKWHVFS HPNCTIRSDL IDLHVYMFSK ALFPAENIDY FSIRFHYIPF LTRSQDMPIS RGYLEHSVTD SELDIVDTIK TTSGGLNIFQ GESKLDNMHD IGTKYTSVSY YIQYAIGKDE CMRINRPETF MHVSLKYLTG NFFENVTIKN SNIAENVKFL GKANVIKSVI MENVTIGNNV ILKGCIICSG AVVGDDCQLT DCQIQYSHTI ESGTVASKQI FPATDYSL //