ID A0A1N6LX74_BABMR Unreviewed; 418 AA. AC A0A1N6LX74; DT 15-MAR-2017, integrated into UniProtKB/TrEMBL. DT 15-MAR-2017, sequence version 1. DT 24-JAN-2024, entry version 15. DE RecName: Full=eIF-2B GDP-GTP exchange factor subunit gamma {ECO:0000256|ARBA:ARBA00041310}; GN ORFNames=BMR1_01G03400 {ECO:0000313|EMBL:SIO73478.1}; OS Babesia microti (strain RI). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida; OC Babesiidae; Babesia. OX NCBI_TaxID=1133968 {ECO:0000313|EMBL:SIO73478.1, ECO:0000313|Proteomes:UP000002899}; RN [1] {ECO:0000313|EMBL:SIO73478.1, ECO:0000313|Proteomes:UP000002899} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=RI {ECO:0000313|EMBL:SIO73478.1, RC ECO:0000313|Proteomes:UP000002899}; RX PubMed=22833609; DOI=10.1093/nar/gks700; RA Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V., RA Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B., RA Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H., RA Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T., RA Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V., RA Ben Mamoun C.; RT "Sequencing of the smallest Apicomplexan genome from the human pathogen RT Babesia microti."; RL Nucleic Acids Res. 40:9102-9114(2012). CC -!- FUNCTION: Catalyzes the exchange of eukaryotic initiation factor 2- CC bound GDP for GTP. {ECO:0000256|ARBA:ARBA00002757}. CC -!- SUBUNIT: Complex of five different subunits; alpha, beta, gamma, delta CC and epsilon. {ECO:0000256|ARBA:ARBA00011383}. CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family. CC {ECO:0000256|ARBA:ARBA00007878}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FO082871; SIO73478.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1N6LX74; -. DR VEuPathDB; PiroplasmaDB:BMR1_01G03400; -. DR OrthoDB; 161736at2759; -. DR Proteomes; UP000002899; Chromosome I. DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1. DR InterPro; IPR005835; NTP_transferase_dom. DR InterPro; IPR029044; Nucleotide-diphossugar_trans. DR PANTHER; PTHR45989; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1. DR PANTHER; PTHR45989:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA; 1. DR Pfam; PF00483; NTP_transferase; 1. DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1. PE 3: Inferred from homology; KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, KW ECO:0000313|EMBL:SIO73478.1}; KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917}; KW Reference proteome {ECO:0000313|Proteomes:UP000002899}. FT DOMAIN 23..161 FT /note="Nucleotidyl transferase" FT /evidence="ECO:0000259|Pfam:PF00483" SQ SEQUENCE 418 AA; 46619 MW; 54F1D6E30424C28E CRC64; MSPPSSDHGD SIAEHHDTSK IQGIILASNS TFNISILTAE HSKALLSING KPLIWHSIKL LTDNGIKDIF VVIEPKYKPA LEAAFKDFID AVTVTIISLD AEVLGSLDAL KFLREYITND FIVIPCDIYG KVDITGLIKS HYQSHSGCTA LLYHNEKDTS NSYRCLTLLD EATHKLISIV DSTSFNAGNS LFIHKWHVFS HPNCTIRSDL IDLHVYMFSK ALFPAENIDY FSIRFHYIPF LTRSQDMPIS RGYLEHSVTD SELDIVDTIK TTSGGLNIFQ GESKLDNMHD IGTKYTSVSY YIQYAIGKDE CMRINRPETF MHVSLKYLTG NFFENVTIKN SNIAENVKFL GKANVIKSVI MENVTIGNNV ILKGCIICSG AVVGDDCQLT DCQIQYSHTI ESGTVASKQI FPATDYSL //