ID TILB_XENLA Reviewed; 469 AA. AC A0A1L8G016; DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot. DT 15-MAR-2017, sequence version 1. DT 07-APR-2021, entry version 11. DE RecName: Full=Protein tilB homolog; DE AltName: Full=Leucine-rich repeat-containing protein 6; GN Name=lrrc6; ORFNames=XELAEV_18032374mg {ECO:0000312|EMBL:OCT77178.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus. OX NCBI_TaxID=8355 {ECO:0000312|EMBL:OCT77178.1}; RN [1] {ECO:0000312|Proteomes:UP000186698} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=J {ECO:0000312|Proteomes:UP000186698}; RX PubMed=27762356; DOI=10.1038/nature19840; RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S., RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., Quigley I., RA Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., Simakov O., RA Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., Watanabe M., RA Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., van Kruijsbergen I., RA Shu S., Carlson J., Kinoshita T., Ohta Y., Mawaribuchi S., Jenkins J., RA Grimwood J., Schmutz J., Mitros T., Mozaffari S.V., Suzuki Y., Haramoto Y., RA Yamamoto T.S., Takagi C., Heald R., Miller K., Haudenschild C., Kitzman J., RA Nakayama T., Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., RA Karimi K., Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., RA Shendure J., DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M., RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., Veenstra G.J., RA Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.; RT "Genome evolution in the allotetraploid frog Xenopus laevis."; RL Nature 538:336-343(2016). RN [2] RP SUBCELLULAR LOCATION. RX PubMed=30561330; DOI=10.7554/elife.38497; RA Huizar R.L., Lee C., Boulgakov A.A., Horani A., Tu F., Marcotte E.M., RA Brody S.L., Wallingford J.B.; RT "A liquid-like organelle at the root of motile ciliopathy."; RL Elife 7:0-0(2018). RN [3] RP SUBCELLULAR LOCATION. RX PubMed=33263282; DOI=10.7554/elife.58662; RA Lee C., Cox R.M., Papoulas O., Horani A., Drew K., Devitt C.C., Brody S.L., RA Marcotte E.M., Wallingford J.B.; RT "Functional partitioning of a liquid-like organelle during assembly of RT axonemal dyneins."; RL Elife 9:0-0(2020). CC -!- FUNCTION: May play a role in dynein arm assembly, hence essential for CC proper axoneme building for cilia motility (By similarity). May play a CC crucial role in regulating cilia motility in pronephric tubules, cloaca CC and neural tube. May be required for establishing left-right asymmetry CC of the body plan; controls cell fate and convergent extension (CE) CC movements during gastrulation, respectively, via the Wnt and the planar CC cell polarity (PCP) signaling pathways. Required for the proper CC development of renal glomeruli and tubules (By similarity). CC {ECO:0000250|UniProtKB:B3DH20, ECO:0000250|UniProtKB:Q86X45}. CC -!- SUBCELLULAR LOCATION: Dynein axonemal particle CC {ECO:0000269|PubMed:30561330, ECO:0000269|PubMed:33263282}. Cell CC projection, cilium {ECO:0000250|UniProtKB:Q86X45}. Note=Localized to CC cytoplasmic puncta in ciliated cells. In the semicircular canal, CC localized to kinocilia (By similarity). {ECO:0000250|UniProtKB:B3DH20}. CC -!- SIMILARITY: Belongs to the tilB family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CM004476; OCT77178.1; -; Genomic_DNA. DR OMA; RELYMLG; -. DR Proteomes; UP000186698; Chromosome 6l. DR Proteomes; UP000186698; Unassembled WGS sequence. DR Gene3D; 3.80.10.10; -; 1. DR InterPro; IPR001611; Leu-rich_rpt. DR InterPro; IPR032675; LRR_dom_sf. DR InterPro; IPR003603; U2A'_phosphoprotein32A_C. DR SMART; SM00446; LRRcap; 1. DR PROSITE; PS51450; LRR; 5. PE 3: Inferred from homology; KW Cell projection; Cilium; Coiled coil; Cytoplasm; Leucine-rich repeat; KW Reference proteome; Repeat. FT CHAIN 1..469 FT /note="Protein tilB homolog" FT /id="PRO_0000452439" FT REPEAT 20..43 FT /note="LRR 1" FT /evidence="ECO:0000255" FT REPEAT 44..65 FT /note="LRR 2" FT /evidence="ECO:0000255" FT REPEAT 66..89 FT /note="LRR 3" FT /evidence="ECO:0000255" FT REPEAT 90..110 FT /note="LRR 4" FT /evidence="ECO:0000255" FT DOMAIN 114..135 FT /note="LRRCT" FT /evidence="ECO:0000255" SQ SEQUENCE 469 AA; 54340 MW; 3565B6B4B25C783A CRC64; MPTISEDLIR RRAEHNNCEI FSLEEISLHQ QDLERIEHID KWCRELKILY LQNNLIGKIE NVSKLKKLEY LNLALNNIEK IENLEGCESL QKLDLTVNFV GELSSINSLQ ENLHLRELYL VGNPCAEYEG YRQYVVATLP QLKWLDGKEI ERSERIQALQ DYPQVQGRMK EQQEAYLRKR AAEREEARSK LQGKQKESRK TQEKKPGFDR RWYTDINNTI PDPVEKPDPT EQNGDETALR KAEEEEEKEF WSQPSQYTPE SRLETHRYLE EKRKSKESSS EGELKKKPPR TLITAEGRVL NVNESKLDFS LVDDEENNQF VLDLAIYRHL DTSLVDVDVQ PSYIKVLVKE KPFQLVLPAE VKPDSSSAKR SQTTGHLVVT MPKAIGVIQT KRAKSPVVEE QTRKNPPKCS KTFEKLEVDP KACSVPDFAN IVQEKKTQAQ GPLQFHKNKV KDTEDSEDFI DNTDVPPLM //