ID A0A1L1SVJ3_MOUSE Unreviewed; 358 AA. AC A0A1L1SVJ3; DT 15-FEB-2017, integrated into UniProtKB/TrEMBL. DT 15-FEB-2017, sequence version 1. DT 29-MAY-2024, entry version 32. DE RecName: Full=C-X-C chemokine receptor type 6 {ECO:0000256|ARBA:ARBA00019717}; GN Name=Cxcr6 {ECO:0000313|Ensembl:ENSMUSP00000151182.2, GN ECO:0000313|MGI:MGI:1934582}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000151182.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000151182.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151182.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000151182.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151182.2}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A1L1SVJ3; -. DR SMR; A0A1L1SVJ3; -. DR ProteomicsDB; 357577; -. DR Antibodypedia; 12723; 754 antibodies from 43 providers. DR Ensembl; ENSMUST00000216072.2; ENSMUSP00000151182.2; ENSMUSG00000048521.9. DR AGR; MGI:1934582; -. DR MGI; MGI:1934582; Cxcr6. DR VEuPathDB; HostDB:ENSMUSG00000048521; -. DR GeneTree; ENSGT01030000234667; -. DR Proteomes; UP000000589; Chromosome 9. DR Bgee; ENSMUSG00000048521; Expressed in peripheral lymph node and 66 other cell types or tissues. DR ExpressionAtlas; A0A1L1SVJ3; baseline and differential. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0019957; F:C-C chemokine binding; IEA:TreeGrafter. DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:TreeGrafter. DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro. DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro. DR GO; GO:0019722; P:calcium-mediated signaling; IEA:TreeGrafter. DR GO; GO:0060326; P:cell chemotaxis; IEA:TreeGrafter. DR GO; GO:0006955; P:immune response; IEA:TreeGrafter. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:TreeGrafter. DR CDD; cd15173; 7tmA_CXCR6; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR002235; Chemokine_CXCR6. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF705; C-X-C CHEMOKINE RECEPTOR TYPE 6; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01105; CXCCHMKINER6. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:A0A1L1SVJ3}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 48..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 86..107 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 127..150 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 162..185 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 205..227 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 248..271 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 291..311 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 64..304 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 358 AA; 41202 MW; 4D886319BCEE59BE CRC64; MFAPTDAMDD GHQESALYDG HYEGDFWLFN NSSDNSQENK RFLKFKEVFL PCVYLVVFVF GLLGNSLVLI IYIFYQKLRT LTDVFLLNLP LADLVFVCTL PFWAYAGTYE WVFGTVMCKT LRGMYTMNFY VSMLTLTCIT VDRFIVVVQA TKAFNRQAKW KIWGQVICLL IWVVSLLVSL PQIIYGHVQD IDKLICQYHS EEISTMVLVI QMTLGFFLPL LTMILCYSGI IKTLLHARNF QKHKSLKIIF LVVAVFLLTQ TPFNLAMLIQ STSWEYYTIT SFKYAIVVTE AIAYFRACLN PVLYAFVGLK FRKNVWKLMK DIGCLSHLGV SSQWKSSEDS SKTCSASHNV ETTSMFQL //