ID A0A1L1SVJ3_MOUSE Unreviewed; 358 AA. AC A0A1L1SVJ3; DT 15-FEB-2017, integrated into UniProtKB/TrEMBL. DT 15-FEB-2017, sequence version 1. DT 24-JAN-2024, entry version 30. DE RecName: Full=C-X-C chemokine receptor type 6 {ECO:0000256|ARBA:ARBA00019717}; GN Name=Cxcr6 {ECO:0000313|Ensembl:ENSMUSP00000151182.2, GN ECO:0000313|MGI:MGI:1934582}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000151182.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000151182.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151182.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0000313|Ensembl:ENSMUSP00000151182.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000151182.2}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A1L1SVJ3; -. DR SMR; A0A1L1SVJ3; -. DR ProteomicsDB; 357577; -. DR Antibodypedia; 12723; 754 antibodies from 44 providers. DR Ensembl; ENSMUST00000216072.2; ENSMUSP00000151182.2; ENSMUSG00000048521.9. DR AGR; MGI:1934582; -. DR MGI; MGI:1934582; Cxcr6. DR VEuPathDB; HostDB:ENSMUSG00000048521; -. DR GeneTree; ENSGT01030000234667; -. DR Proteomes; UP000000589; Chromosome 9. DR Bgee; ENSMUSG00000048521; Expressed in peripheral lymph node and 66 other cell types or tissues. DR ExpressionAtlas; A0A1L1SVJ3; baseline and differential. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro. DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro. DR GO; GO:0006935; P:chemotaxis; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR CDD; cd15173; 7tmA_CXCR6; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR002235; Chemokine_CXCR6. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR10489:SF705; C-X-C CHEMOKINE RECEPTOR TYPE 6; 1. DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR01105; CXCCHMKINER6. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU000688}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0007829|EPD:A0A1L1SVJ3}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Transducer {ECO:0000256|RuleBase:RU000688}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000688}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 48..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 86..107 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 127..150 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 162..185 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 205..227 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 248..271 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 291..311 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 64..304 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 358 AA; 41202 MW; 4D886319BCEE59BE CRC64; MFAPTDAMDD GHQESALYDG HYEGDFWLFN NSSDNSQENK RFLKFKEVFL PCVYLVVFVF GLLGNSLVLI IYIFYQKLRT LTDVFLLNLP LADLVFVCTL PFWAYAGTYE WVFGTVMCKT LRGMYTMNFY VSMLTLTCIT VDRFIVVVQA TKAFNRQAKW KIWGQVICLL IWVVSLLVSL PQIIYGHVQD IDKLICQYHS EEISTMVLVI QMTLGFFLPL LTMILCYSGI IKTLLHARNF QKHKSLKIIF LVVAVFLLTQ TPFNLAMLIQ STSWEYYTIT SFKYAIVVTE AIAYFRACLN PVLYAFVGLK FRKNVWKLMK DIGCLSHLGV SSQWKSSEDS SKTCSASHNV ETTSMFQL //