ID   A0A1J7FVN2_LUPAN        Unreviewed;      1047 AA.
AC   A0A1J7FVN2;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Cellulose synthase {ECO:0000256|RuleBase:RU361116};
DE            EC=2.4.1.12 {ECO:0000256|RuleBase:RU361116};
GN   ORFNames=TanjilG_15037 {ECO:0000313|EMBL:OIV92046.1};
OS   Lupinus angustifolius (Narrow-leaved blue lupine).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   genistoids sensu lato; core genistoids; Genisteae; Lupinus.
OX   NCBI_TaxID=3871 {ECO:0000313|EMBL:OIV92046.1, ECO:0000313|Proteomes:UP000188354};
RN   [1] {ECO:0000313|EMBL:OIV92046.1, ECO:0000313|Proteomes:UP000188354}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Tanjil {ECO:0000313|Proteomes:UP000188354};
RC   TISSUE=Whole plant {ECO:0000313|EMBL:OIV92046.1};
RX   PubMed=27557478; DOI=10.1111/pbi.12615;
RA   Hane J.K., Ming Y., Kamphuis L.G., Nelson M.N., Garg G., Atkins C.A.,
RA   Bayer P.E., Bravo A., Bringans S., Cannon S., Edwards D., Foley R.,
RA   Gao L.L., Harrison M.J., Huang W., Hurgobin B., Li S., Liu C.W.,
RA   McGrath A., Morahan G., Murray J., Weller J., Jian J., Singh K.B.;
RT   "A comprehensive draft genome sequence for lupin (Lupinus angustifolius),
RT   an emerging health food: insights into plant-microbe interactions and
RT   legume evolution.";
RL   Plant Biotechnol. J. 15:318-330(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-
CC         beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:19929, Rhea:RHEA-
CC         COMP:10033, Rhea:RHEA-COMP:10034, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18246, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00000122,
CC         ECO:0000256|RuleBase:RU361116};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU361116};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000256|RuleBase:RU361116};
CC   -!- PATHWAY: Glycan metabolism; plant cellulose biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004768, ECO:0000256|RuleBase:RU361116}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC       ECO:0000256|RuleBase:RU361116}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361116}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. Plant
CC       cellulose synthase subfamily. {ECO:0000256|ARBA:ARBA00007548,
CC       ECO:0000256|RuleBase:RU361116}.
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DR   EMBL; CM007379; OIV92046.1; -; Genomic_DNA.
DR   RefSeq; XP_019425619.1; XM_019570074.1.
DR   AlphaFoldDB; A0A1J7FVN2; -.
DR   STRING; 3871.A0A1J7FVN2; -.
DR   EnsemblPlants; OIV92046; OIV92046; TanjilG_15037.
DR   GeneID; 109334350; -.
DR   Gramene; OIV92046; OIV92046; TanjilG_15037.
DR   KEGG; lang:109334350; -.
DR   OMA; ENGDYNP; -.
DR   OrthoDB; 1210919at2759; -.
DR   UniPathway; UPA00695; -.
DR   Proteomes; UP000188354; Chromosome LG19.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016760; F:cellulose synthase (UDP-forming) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0030244; P:cellulose biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd16617; mRING-HC-C4C4_CesA; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR005150; Cellulose_synth.
DR   InterPro; IPR027934; CES_Znf_RING.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR13301:SF91; CELLULOSE SYNTHASE A CATALYTIC SUBUNIT 4 [UDP-FORMING]; 1.
DR   PANTHER; PTHR13301; X-BOX TRANSCRIPTION FACTOR-RELATED; 1.
DR   Pfam; PF03552; Cellulose_synt; 1.
DR   Pfam; PF14569; zf-UDP; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU361116};
KW   Cell wall biogenesis/degradation {ECO:0000256|RuleBase:RU361116};
KW   Cellulose biosynthesis {ECO:0000256|ARBA:ARBA00022916,
KW   ECO:0000256|RuleBase:RU361116};
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW   ECO:0000256|RuleBase:RU361116}; Manganese {ECO:0000256|ARBA:ARBA00023211};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361116};
KW   Metal-binding {ECO:0000256|RuleBase:RU361116};
KW   Reference proteome {ECO:0000313|Proteomes:UP000188354};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361116};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361116};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361116};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361116};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU361116}.
FT   TRANSMEM        222..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        251..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        825..846
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        858..881
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        893..912
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        945..968
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        974..996
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   TRANSMEM        1008..1028
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361116"
FT   DOMAIN          31..101
FT                   /note="Cellulose synthase RING-type zinc finger"
FT                   /evidence="ECO:0000259|Pfam:PF14569"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1047 AA;  118999 MW;  B585335861B283E7 CRC64;
     MASNSMAGFI TGSHSHISHD SDEHQPPTLQ PSSKECRVCG DEIGYKEDGV LFVACHVCAF
     PVCKPCYEYE RSEGNQLCPQ CNTRYKRQKG CPRVAGDEEE NFDDDDFEDE FQIKNHHDDD
     VDREHDVNHV ENGDYNQQKL HTGLAFSSAG SVAGKDLEGD RDFYSNAEWE ERVEKWKVRQ
     EKRGLLNKED GKEDQGEDDD YLLAEARQPL WRKVPIASSL INPYRIVIIM RLVILAFFFR
     FRILTPAYDA YPLWLISVIC EIWFALSWIL DQFPKWLPIT RETYLDRLSI RFEREGEPNQ
     LSPVDVFVSS VDPLKEPPII TANTVLSILS LDYPVEKVCC YVSDDGASML LFDSLAETAE
     FARRWVPFTK KYNIEPRAPE YYFSQKIDYL KDKVQPTFVK ERRAMKREYE EFKVKINALV
     AKALKKPEEG WVMQDGTPWP GNNTRDHPGM IQVYLGNAGA LDVEGKELPR LVYISREKRP
     GYPHHKKAGA MNALVRVSAV LTNAPFMLNL DCDHYINNSK AIREAMCFLM DPQLGKKLCY
     VQFPQRFDGI DRHDRYANRN TVFFDINMKG LDGIQGPVYV GTGTVFNRQA LYGYDPPVSE
     KRPKMTCDCW PTWCCFCCGG SRKSKAKKKS GKRGIFGALY SKKKKMMGKD YVRKGSGAMF
     DLEEIEEGLE GYEDLEKSSL MSQKNFEKRF GQSPVFIAST LVENGGLPEG TNTQSLVKEA
     IHVISCGYEE KTEWGKEIGW IYGSVTEDIL TGFKMHCRGW KSVYCMPKRP AFKGSAPINL
     SDRLHQVLRW ALGSVEIFLS RHCPLWYGYG GKLKYLERLA YTNTIVYPFT SIPLIAYCTI
     PAVCLLTGKF IIPTLTNLAS VWFMALFISI ILTGVLELRW SGVTIEDWWR NEQFWVIGGV
     SAHLFAVFQG LLKVLAGVDT NFTVTAKAAD DAEFGELYLF KWTTLLIPPT TLIILNIVGV
     VAGVSGAINN GSGSWGPLFG KLFFAFWVIV HLYPFLKGLM GKQNRTPTIV VLWSILLASI
     FSLIWVRIDP FLPKQTGPIL KQCGVEC
//