ID A0A1I7UAU4_9PELO Unreviewed; 355 AA. AC A0A1I7UAU4; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 29-MAY-2024, entry version 37. DE SubName: Full=Nuclear receptor domain-containing protein {ECO:0000313|WBParaSite:Csp11.Scaffold629.g16615.t1}; OS Caenorhabditis tropicalis. OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; OC Caenorhabditis. OX NCBI_TaxID=1561998 {ECO:0000313|Proteomes:UP000095282, ECO:0000313|WBParaSite:Csp11.Scaffold629.g16615.t1}; RN [1] {ECO:0000313|WBParaSite:Csp11.Scaffold629.g16615.t1} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (NOV-2016) to UniProtKB. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. CC {ECO:0000256|ARBA:ARBA00005993}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A1I7UAU4; -. DR STRING; 1561998.A0A1I7UAU4; -. DR WBParaSite; Csp11.Scaffold629.g16615.t1; Csp11.Scaffold629.g16615.t1; Csp11.Scaffold629.g16615. DR eggNOG; KOG3575; Eukaryota. DR Proteomes; UP000095282; Unplaced. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0004879; F:nuclear receptor activity; IEA:TreeGrafter. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0030154; P:cell differentiation; IEA:TreeGrafter. DR CDD; cd06960; NR_DBD_HNF4A; 1. DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1. DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1. DR InterPro; IPR049636; HNF4-like_DBD. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR PANTHER; PTHR24083; NUCLEAR HORMONE RECEPTOR; 1. DR PANTHER; PTHR24083:SF163; NUCLEAR HORMONE RECEPTOR FAMILY; 1. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}. FT DOMAIN 1..44 FT /note="Nuclear receptor" FT /evidence="ECO:0000259|PROSITE:PS51030" FT DOMAIN 112..351 FT /note="NR LBD" FT /evidence="ECO:0000259|PROSITE:PS51843" FT REGION 60..82 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 61..82 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 355 AA; 40894 MW; 395A02AAC28C1B12 CRC64; MKKQIFVCQH EKNCPVDKSI RCACRFCRFE KCLKVGMDRS ALQASRDRIG YTKRTRKPKL KSVSFSSSGS MSPSSYQADS PGYSQKAFET YWSYVASREK ASNELRLTEY LPKRSLKEAL CSKSLLNDPI FLSKHATVSP RHTFTELRFI TQSDYHYWHE RDWFVLTEYA KTFKVYESLS YSDKASLVRH SAITLPALNQ VYNSPDYGPD TVVFPDGTYY DRTHEPTRPA GLNRKKYQVL DLVLKPFREI EINFNEFAAF KAITFLNPDA DVSLTAKLAI NEERIAVTKQ LFAFMVRNDG IDKAIKRFSR LILIGTSMSK MACESKEAVW IADFFENIGY TSFAKELFFG DQNSD //