ID A0A1I7KB92_9RHIZ Unreviewed; 149 AA. AC A0A1I7KB92; DT 22-NOV-2017, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 1. DT 31-JAN-2018, entry version 3. DE RecName: Full=3-dehydroquinate dehydratase {ECO:0000256|HAMAP-Rule:MF_00169, ECO:0000256|SAAS:SAAS00877024}; DE Short=3-dehydroquinase {ECO:0000256|HAMAP-Rule:MF_00169}; DE EC=4.2.1.10 {ECO:0000256|HAMAP-Rule:MF_00169, ECO:0000256|SAAS:SAAS00877024}; DE AltName: Full=Type II DHQase {ECO:0000256|HAMAP-Rule:MF_00169}; GN Name=aroQ {ECO:0000256|HAMAP-Rule:MF_00169}; GN ORFNames=SAMN02799643_03382 {ECO:0000313|EMBL:SFU94697.1}; OS Methylobacterium sp. UNCCL125. OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; OC Methylobacteriaceae; Methylobacterium. OX NCBI_TaxID=1502759 {ECO:0000313|EMBL:SFU94697.1, ECO:0000313|Proteomes:UP000199260}; RN [1] {ECO:0000313|EMBL:SFU94697.1, ECO:0000313|Proteomes:UP000199260} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UNCCL125 {ECO:0000313|EMBL:SFU94697.1, RC ECO:0000313|Proteomes:UP000199260}; RA de Groot N.N.; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes a trans-dehydration via an enolate CC intermediate. {ECO:0000256|HAMAP-Rule:MF_00169}. CC -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. CC {ECO:0000256|HAMAP-Rule:MF_00169, ECO:0000256|SAAS:SAAS00877046}. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and CC phosphoenolpyruvate: step 3/7. {ECO:0000256|HAMAP-Rule:MF_00169}. CC -!- SUBUNIT: Homododecamer. {ECO:0000256|HAMAP-Rule:MF_00169, CC ECO:0000256|SAAS:SAAS00877052}. CC -!- SIMILARITY: Belongs to the type-II 3-dehydroquinase family. CC {ECO:0000256|HAMAP-Rule:MF_00169, ECO:0000256|SAAS:SAAS00877041}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FPBW01000015; SFU94697.1; -; Genomic_DNA. DR RefSeq; WP_043382565.1; NZ_FPBW01000015.1. DR UniPathway; UPA00053; UER00086. DR Proteomes; UP000199260; Unassembled WGS sequence. DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:UniProtKB-UniRule. DR GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd00466; DHQase_II; 1. DR Gene3D; 3.40.50.9100; -; 1. DR HAMAP; MF_00169; AroQ; 1. DR InterPro; IPR001874; DHquinase_II. DR InterPro; IPR018509; DHquinase_II_CS. DR InterPro; IPR036441; DHquinase_II_sf. DR PANTHER; PTHR21272; PTHR21272; 1. DR Pfam; PF01220; DHquinase_II; 1. DR PIRSF; PIRSF001399; DHquinase_II; 1. DR SUPFAM; SSF52304; SSF52304; 1. DR TIGRFAMs; TIGR01088; aroQ; 1. DR PROSITE; PS01029; DEHYDROQUINASE_II; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00169}; KW Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00169}; KW Complete proteome {ECO:0000313|Proteomes:UP000199260}; KW Lyase {ECO:0000256|HAMAP-Rule:MF_00169, KW ECO:0000256|SAAS:SAAS00877078}. FT REGION 102 103 Substrate binding. {ECO:0000256|HAMAP- FT Rule:MF_00169, ECO:0000256|PIRSR: FT PIRSR001399-2}. FT ACT_SITE 24 24 Proton acceptor. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 1}. FT ACT_SITE 101 101 Proton donor. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 1}. FT BINDING 75 75 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 2}. FT BINDING 81 81 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 2}. FT BINDING 88 88 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 2}. FT BINDING 112 112 Substrate. {ECO:0000256|HAMAP-Rule: FT MF_00169, ECO:0000256|PIRSR:PIRSR001399- FT 2}. FT SITE 19 19 Transition state stabilizer. FT {ECO:0000256|HAMAP-Rule:MF_00169, FT ECO:0000256|PIRSR:PIRSR001399-3}. SQ SEQUENCE 149 AA; 16133 MW; 7CFCEE864C8BBA7E CRC64; MNDTILVLNG PNLNLLGKRQ PEIYGRETLA DVEALCRETA AGFGLTVDFR QSNAEHVLID AIHDFRVGSA GIVINAGAYT HTSVALLDAL NTCEVPVIEY HISNVHRREA FRHHSYISLA ATAVLAGFGT HGYALAIRHL AHLRAGKPA //