ID A0A1I5MDY7_9BACI Unreviewed; 306 AA. AC A0A1I5MDY7; DT 22-NOV-2017, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 1. DT 11-DEC-2019, entry version 15. DE RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00055375}; GN Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808}; GN ORFNames=SAMN05518683_102182 {ECO:0000313|EMBL:SFP07146.1}; OS Salibacterium halotolerans. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae. OX NCBI_TaxID=1884432 {ECO:0000313|EMBL:SFP07146.1, ECO:0000313|Proteomes:UP000198892}; RN [1] {ECO:0000313|EMBL:SFP07146.1, ECO:0000313|Proteomes:UP000198892} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S7 {ECO:0000313|EMBL:SFP07146.1, RC ECO:0000313|Proteomes:UP000198892}; RA de Groot N.N.; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing CC the cutting and rejoining of the recombining DNA molecules. The XerC- CC XerD complex is essential to convert dimers of the bacterial chromosome CC into monomers to permit their segregation at cell division. It also CC contributes to the segregational stability of plasmids. CC {ECO:0000256|HAMAP-Rule:MF_01808}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP- CC Rule:MF_01808, ECO:0000256|SAAS:SAAS00608017}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808, CC ECO:0000256|SAAS:SAAS00019473}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily. CC {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00608022}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FOXD01000002; SFP07146.1; -; Genomic_DNA. DR Proteomes; UP000198892; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011931; Recomb_XerC. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02224; recomb_XerC; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608018}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00094312}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00298355}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS01225217}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS01232192}. FT DOMAIN 11..92 FT /note="Integrase_SAM-like_N" FT /evidence="ECO:0000259|Pfam:PF02899" FT DOMAIN 114..287 FT /note="Phage_integrase" FT /evidence="ECO:0000259|Pfam:PF00589" FT ACT_SITE 150 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 174 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 247 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 250 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 273 FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" FT ACT_SITE 282 FT /note="O-(3'-phospho-DNA)-tyrosine intermediate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808" SQ SEQUENCE 306 AA; 35692 MW; D94D80CD62C2E7E6 CRC64; MKEEWKYWND TFLQYLQVEK NASSLTIDAY RKDLEDYFRF LQTEGIQNPL DVDMNVARLY LTRLFDEQYG RSSAARKISV LRTFYRYVKK EGQMETNPFA SSSLPKKQKK LPRFLYEKEL EALLDSFDIE KDLDQRDLAL FELLYATGLR VSEMCRLEEQ HLDEDLGTIL VHGKGDRERY VPVGSFAMEA LDHYRRHARR RLVQKNGGDT SVLFLNNKGT PLTDRGIRYI VNKRVKDVSA TLQLSPHDLR HTFATHLLNQ GADLRSVQQL LGHANLSTTQ IYTHVTKDRL RDVYNNAHPR SEKNGG //