ID A0A1I5MDY7_9BACI Unreviewed; 306 AA. AC A0A1I5MDY7; DT 22-NOV-2017, integrated into UniProtKB/TrEMBL. DT 22-NOV-2017, sequence version 1. DT 16-OCT-2019, entry version 13. DE RecName: Full=Tyrosine recombinase XerC {ECO:0000256|HAMAP-Rule:MF_01808, ECO:0000256|SAAS:SAAS00055375}; GN Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808}; GN ORFNames=SAMN05518683_102182 {ECO:0000313|EMBL:SFP07146.1}; OS Salibacterium halotolerans. OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae. OX NCBI_TaxID=1884432 {ECO:0000313|EMBL:SFP07146.1, ECO:0000313|Proteomes:UP000198892}; RN [1] {ECO:0000313|EMBL:SFP07146.1, ECO:0000313|Proteomes:UP000198892} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=S7 {ECO:0000313|EMBL:SFP07146.1, RC ECO:0000313|Proteomes:UP000198892}; RA de Groot N.N.; RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by CC catalyzing the cutting and rejoining of the recombining DNA CC molecules. The XerC-XerD complex is essential to convert dimers of CC the bacterial chromosome into monomers to permit their segregation CC at cell division. It also contributes to the segregational CC stability of plasmids. {ECO:0000256|HAMAP-Rule:MF_01808}. CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP- CC Rule:MF_01808, ECO:0000256|SAAS:SAAS00608017}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808, CC ECO:0000256|SAAS:SAAS00019473}. CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC CC subfamily. {ECO:0000256|HAMAP-Rule:MF_01808, CC ECO:0000256|SAAS:SAAS00608022}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FOXD01000002; SFP07146.1; -; Genomic_DNA. DR Proteomes; UP000198892; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule. DR GO; GO:0006313; P:transposition, DNA-mediated; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.150.130; -; 1. DR Gene3D; 1.10.443.10; -; 1. DR HAMAP; MF_01808; Recomb_XerC_XerD; 1. DR InterPro; IPR011010; DNA_brk_join_enz. DR InterPro; IPR013762; Integrase-like_cat_sf. DR InterPro; IPR002104; Integrase_catalytic. DR InterPro; IPR010998; Integrase_recombinase_N. DR InterPro; IPR004107; Integrase_SAM-like_N. DR InterPro; IPR011931; Recomb_XerC. DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD. DR Pfam; PF02899; Phage_int_SAM_1; 1. DR Pfam; PF00589; Phage_integrase; 1. DR SUPFAM; SSF56349; SSF56349; 1. DR TIGRFAMs; TIGR02224; recomb_XerC; 1. PE 3: Inferred from homology; KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608023}; KW Cell division {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608024}; KW Chromosome partition {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00608018}; KW Complete proteome {ECO:0000313|Proteomes:UP000198892}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00094312}; KW DNA integration {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00298355}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS01225217}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01808, KW ECO:0000256|SAAS:SAAS00424103}. FT DOMAIN 11 92 Integrase_SAM-like_N. {ECO:0000259|Pfam: FT PF02899}. FT DOMAIN 114 287 Phage_integrase. {ECO:0000259|Pfam: FT PF00589}. FT ACT_SITE 150 150 {ECO:0000256|HAMAP-Rule:MF_01808}. FT ACT_SITE 174 174 {ECO:0000256|HAMAP-Rule:MF_01808}. FT ACT_SITE 247 247 {ECO:0000256|HAMAP-Rule:MF_01808}. FT ACT_SITE 250 250 {ECO:0000256|HAMAP-Rule:MF_01808}. FT ACT_SITE 273 273 {ECO:0000256|HAMAP-Rule:MF_01808}. FT ACT_SITE 282 282 O-(3'-phospho-DNA)-tyrosine intermediate. FT {ECO:0000256|HAMAP-Rule:MF_01808}. SQ SEQUENCE 306 AA; 35692 MW; D94D80CD62C2E7E6 CRC64; MKEEWKYWND TFLQYLQVEK NASSLTIDAY RKDLEDYFRF LQTEGIQNPL DVDMNVARLY LTRLFDEQYG RSSAARKISV LRTFYRYVKK EGQMETNPFA SSSLPKKQKK LPRFLYEKEL EALLDSFDIE KDLDQRDLAL FELLYATGLR VSEMCRLEEQ HLDEDLGTIL VHGKGDRERY VPVGSFAMEA LDHYRRHARR RLVQKNGGDT SVLFLNNKGT PLTDRGIRYI VNKRVKDVSA TLQLSPHDLR HTFATHLLNQ GADLRSVQQL LGHANLSTTQ IYTHVTKDRL RDVYNNAHPR SEKNGG //