ID A0A1F8DY91_9BACT Unreviewed; 689 AA. AC A0A1F8DY91; DT 15-FEB-2017, integrated into UniProtKB/TrEMBL. DT 15-FEB-2017, sequence version 1. DT 25-APR-2018, entry version 5. DE RecName: Full=K(+)-insensitive pyrophosphate-energized proton pump {ECO:0000256|HAMAP-Rule:MF_01129}; DE EC=3.6.1.1 {ECO:0000256|HAMAP-Rule:MF_01129}; DE AltName: Full=Membrane-bound proton-translocating pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129}; DE AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129}; DE Short=H(+)-PPase {ECO:0000256|HAMAP-Rule:MF_01129}; GN Name=hppA {ECO:0000256|HAMAP-Rule:MF_01129, GN ECO:0000313|EMBL:OGM93513.1}; GN ORFNames=A2935_01400 {ECO:0000313|EMBL:OGM93513.1}; OS Candidatus Wolfebacteria bacterium RIFCSPLOWO2_01_FULL_47_17b. OC Bacteria; Candidatus Wolfebacteria. OX NCBI_TaxID=1802558 {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011}; RN [1] {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=27774985; DOI=10.1038/ncomms13219; RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J., RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., RA Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.; RT "Thousands of microbial genomes shed light on interconnected RT biogeochemical processes in an aquifer system."; RL Nat. Commun. 7:13219-13219(2016). CC -!- FUNCTION: Proton pump that utilizes the energy of pyrophosphate CC hydrolysis as the driving force for proton movement across the CC membrane. Generates a proton motive force. {ECO:0000256|HAMAP- CC Rule:MF_01129}. CC -!- CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate. CC {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP- CC Rule:MF_01129}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP- CC Rule:MF_01129}; Multi-pass membrane protein {ECO:0000256|HAMAP- CC Rule:MF_01129}. CC -!- SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase CC (TC 3.A.10) family. K(+)-insensitive subfamily. CC {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:OGM93513.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MGIS01000012; OGM93513.1; -; Genomic_DNA. DR Proteomes; UP000177011; Unassembled WGS sequence. DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0009678; F:hydrogen-translocating pyrophosphatase activity; IEA:UniProtKB-UniRule. DR GO; GO:0004427; F:inorganic diphosphatase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW. DR HAMAP; MF_01129; PPase_energized_pump; 1. DR InterPro; IPR004131; PPase-energised_H-pump. DR PANTHER; PTHR31998; PTHR31998; 1. DR Pfam; PF03030; H_PPase; 1. DR PIRSF; PIRSF001265; H+-PPase; 1. DR TIGRFAMs; TIGR01104; V_PPase; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129}; KW Complete proteome {ECO:0000313|Proteomes:UP000177011}; KW Hydrogen ion transport {ECO:0000256|HAMAP-Rule:MF_01129}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01129}; KW Ion transport {ECO:0000256|HAMAP-Rule:MF_01129}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01129}; KW Membrane {ECO:0000256|HAMAP-Rule:MF_01129}; KW Reference proteome {ECO:0000313|Proteomes:UP000177011}; KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01129}; KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01129}; KW Transport {ECO:0000256|HAMAP-Rule:MF_01129}. FT TRANSMEM 6 26 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 55 73 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 79 101 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 121 146 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 152 171 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 224 242 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 248 268 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 280 299 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 311 333 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 354 377 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 383 405 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 449 467 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 487 506 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 560 580 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT TRANSMEM 600 621 Helical. {ECO:0000256|HAMAP-Rule: FT MF_01129}. FT SITE 443 443 Determinant of potassium independence. FT {ECO:0000256|HAMAP-Rule:MF_01129}. SQ SEQUENCE 689 AA; 71703 MW; 9A745303C0EAF5D7 CRC64; MQYTNYIIFI PVVLAVAYAA YLMLWLKRQP KGSEKMQEIS KAIRIGARAY LNRQYRTVAI VAIVLFVIIW LVFQNWVLGI GFLLGGILSA LAGYIGLNVS VTSNSKTTQA AHTGLGEAMS VAFRAGSVTG FLVVALGLLG VAGFYLLTGQ DATALIGFGF GASLISVFAR LGGGIFTKAA DVGTDLVGKV EAGIPEDDPR NPGVIADNVG DNVGDCAGMA ADLFETYAVT LTAALLLGAA LLTGQQVFFP LVIGGLAIVA SVVGTLFVRL GKKKGIMHAL YKGLGASVIV SAGLFYLAAQ QFFPENLWSM YISTLIGLAV TVLMVLVTDY YTAKKYRPVQ SISKASESGH GTNIIMGLSV GMESTFLPIL IIAAGIISSY ILANVYGVAL AATAMLSVAG IIVAIDSFGP VTDNAGGIAE MSDAPEEVRK VTDSLDAVGN TTKAVTKGYA IASAGLAALA LFAGFTQEVA TRFELPDFSA LRGFFDITNP FVLVGLLIGA SIPYLFSSIA MKSVGKAAGA IVDEIRRQFR EIKGIMDGTQ KPDYGKAVDI VTKAALKEMI IPALLPVFFI LVVGLGTKLV ADLAITNPYV GASFTPGTVI AAQALGGLLI GVILSGLFVA ISMTSGGAAW DNGKKYIEDG NFGGKGSDAH KAAVTGDTVG DPYKDTAGPA INPLIKVIMI LALLIVPLL //