ID   A0A1F8DY91_9BACT        Unreviewed;       689 AA.
AC   A0A1F8DY91;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   15-MAR-2017, entry version 2.
DE   RecName: Full=K(+)-insensitive pyrophosphate-energized proton pump {ECO:0000256|HAMAP-Rule:MF_01129};
DE            EC=3.6.1.1 {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Membrane-bound proton-translocating pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE            Short=H(+)-PPase {ECO:0000256|HAMAP-Rule:MF_01129};
GN   Name=hppA {ECO:0000256|HAMAP-Rule:MF_01129,
GN   ECO:0000313|EMBL:OGM93513.1};
GN   ORFNames=A2935_01400 {ECO:0000313|EMBL:OGM93513.1};
OS   Candidatus Wolfebacteria bacterium RIFCSPLOWO2_01_FULL_47_17b.
OC   Bacteria; Candidatus Wolfebacteria.
OX   NCBI_TaxID=1802558 {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011};
RN   [1] {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U.,
RA   Brodie E.L., Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected
RT   biogeochemical processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: Proton pump that utilizes the energy of pyrophosphate
CC       hydrolysis as the driving force for proton movement across the
CC       membrane. Generates a proton motive force. {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- CATALYTIC ACTIVITY: Diphosphate + H(2)O = 2 phosphate.
CC       {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01129};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01129}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase (TC
CC       3.A.10) family. K(+)-insensitive subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:OGM93513.1}.
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DR   EMBL; MGIS01000012; OGM93513.1; -; Genomic_DNA.
DR   Proteomes; UP000177011; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0009678; F:hydrogen-translocating pyrophosphatase activity; IEA:InterPro.
DR   GO; GO:0004427; F:inorganic diphosphatase activity; IEA:InterPro.
DR   GO; GO:0015992; P:proton transport; IEA:InterPro.
DR   HAMAP; MF_01129; PPase_energized_pump; 1.
DR   InterPro; IPR004131; PPase-energised_H-pump.
DR   PANTHER; PTHR31998; PTHR31998; 1.
DR   Pfam; PF03030; H_PPase; 1.
DR   PIRSF; PIRSF001265; H+-PPase; 1.
DR   TIGRFAMs; TIGR01104; V_PPase; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Complete proteome {ECO:0000313|Proteomes:UP000177011};
KW   Hydrogen ion transport {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Ion transport {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01129}.
FT   TRANSMEM      6     26       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM     55     73       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM     79    101       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    121    146       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    152    171       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    224    242       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    248    268       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    280    299       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    311    333       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    354    377       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    383    405       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    449    467       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    487    506       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    560    580       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   TRANSMEM    600    621       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01129}.
FT   SITE        443    443       Determinant of potassium independence.
FT                                {ECO:0000256|HAMAP-Rule:MF_01129}.
SQ   SEQUENCE   689 AA;  71703 MW;  9A745303C0EAF5D7 CRC64;
     MQYTNYIIFI PVVLAVAYAA YLMLWLKRQP KGSEKMQEIS KAIRIGARAY LNRQYRTVAI
     VAIVLFVIIW LVFQNWVLGI GFLLGGILSA LAGYIGLNVS VTSNSKTTQA AHTGLGEAMS
     VAFRAGSVTG FLVVALGLLG VAGFYLLTGQ DATALIGFGF GASLISVFAR LGGGIFTKAA
     DVGTDLVGKV EAGIPEDDPR NPGVIADNVG DNVGDCAGMA ADLFETYAVT LTAALLLGAA
     LLTGQQVFFP LVIGGLAIVA SVVGTLFVRL GKKKGIMHAL YKGLGASVIV SAGLFYLAAQ
     QFFPENLWSM YISTLIGLAV TVLMVLVTDY YTAKKYRPVQ SISKASESGH GTNIIMGLSV
     GMESTFLPIL IIAAGIISSY ILANVYGVAL AATAMLSVAG IIVAIDSFGP VTDNAGGIAE
     MSDAPEEVRK VTDSLDAVGN TTKAVTKGYA IASAGLAALA LFAGFTQEVA TRFELPDFSA
     LRGFFDITNP FVLVGLLIGA SIPYLFSSIA MKSVGKAAGA IVDEIRRQFR EIKGIMDGTQ
     KPDYGKAVDI VTKAALKEMI IPALLPVFFI LVVGLGTKLV ADLAITNPYV GASFTPGTVI
     AAQALGGLLI GVILSGLFVA ISMTSGGAAW DNGKKYIEDG NFGGKGSDAH KAAVTGDTVG
     DPYKDTAGPA INPLIKVIMI LALLIVPLL
//