ID A0A1F8DY91_9BACT Unreviewed; 689 AA. AC A0A1F8DY91; DT 15-FEB-2017, integrated into UniProtKB/TrEMBL. DT 15-FEB-2017, sequence version 1. DT 27-MAR-2024, entry version 19. DE RecName: Full=K(+)-insensitive pyrophosphate-energized proton pump {ECO:0000256|HAMAP-Rule:MF_01129}; DE EC=7.1.3.1 {ECO:0000256|HAMAP-Rule:MF_01129}; DE AltName: Full=Membrane-bound proton-translocating pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129}; DE AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129}; DE Short=H(+)-PPase {ECO:0000256|HAMAP-Rule:MF_01129}; GN Name=hppA {ECO:0000256|HAMAP-Rule:MF_01129, GN ECO:0000313|EMBL:OGM93513.1}; GN ORFNames=A2935_01400 {ECO:0000313|EMBL:OGM93513.1}; OS Candidatus Wolfebacteria bacterium RIFCSPLOWO2_01_FULL_47_17b. OC Bacteria; Candidatus Wolfebacteria. OX NCBI_TaxID=1802558 {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011}; RN [1] {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=27774985; DOI=10.1038/ncomms13219; RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J., RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L., RA Williams K.H., Hubbard S.S., Banfield J.F.; RT "Thousands of microbial genomes shed light on interconnected biogeochemical RT processes in an aquifer system."; RL Nat. Commun. 7:13219-13219(2016). CC -!- FUNCTION: Proton pump that utilizes the energy of pyrophosphate CC hydrolysis as the driving force for proton movement across the CC membrane. Generates a proton motive force. {ECO:0000256|HAMAP- CC Rule:MF_01129}. CC -!- CATALYTIC ACTIVITY: CC Reaction=diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate; CC Xref=Rhea:RHEA:13973, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=7.1.3.1; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01129}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01129}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129}; CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01129}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase (TC CC 3.A.10) family. K(+)-insensitive subfamily. {ECO:0000256|HAMAP- CC Rule:MF_01129}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01129}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OGM93513.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MGIS01000012; OGM93513.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1F8DY91; -. DR Proteomes; UP000177011; Unassembled WGS sequence. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0009678; F:diphosphate hydrolysis-driven proton transmembrane transporter activity; IEA:UniProtKB-UniRule. DR GO; GO:0004427; F:inorganic diphosphate phosphatase activity; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR HAMAP; MF_01129; PPase_energized_pump; 1. DR InterPro; IPR004131; PPase-energised_H-pump. DR NCBIfam; TIGR01104; V_PPase; 1. DR PANTHER; PTHR31998; K(+)-INSENSITIVE PYROPHOSPHATE-ENERGIZED PROTON PUMP; 1. DR PANTHER; PTHR31998:SF55; K(+)-STIMULATED PYROPHOSPHATE-ENERGIZED SODIUM PUMP; 1. DR Pfam; PF03030; H_PPase; 1. DR PIRSF; PIRSF001265; H+-PPase; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129}; KW Hydrogen ion transport {ECO:0000256|HAMAP-Rule:MF_01129}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP- KW Rule:MF_01129}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_01129}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01129}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|HAMAP- KW Rule:MF_01129}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_01129}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_01129}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01129}. FT TRANSMEM 6..26 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 55..73 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 79..101 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 121..146 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 152..171 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 224..242 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 248..268 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 280..299 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 311..333 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 354..377 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 383..405 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 449..467 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 487..506 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 560..580 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT TRANSMEM 600..621 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" FT SITE 443 FT /note="Determinant of potassium independence" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01129" SQ SEQUENCE 689 AA; 71703 MW; 9A745303C0EAF5D7 CRC64; MQYTNYIIFI PVVLAVAYAA YLMLWLKRQP KGSEKMQEIS KAIRIGARAY LNRQYRTVAI VAIVLFVIIW LVFQNWVLGI GFLLGGILSA LAGYIGLNVS VTSNSKTTQA AHTGLGEAMS VAFRAGSVTG FLVVALGLLG VAGFYLLTGQ DATALIGFGF GASLISVFAR LGGGIFTKAA DVGTDLVGKV EAGIPEDDPR NPGVIADNVG DNVGDCAGMA ADLFETYAVT LTAALLLGAA LLTGQQVFFP LVIGGLAIVA SVVGTLFVRL GKKKGIMHAL YKGLGASVIV SAGLFYLAAQ QFFPENLWSM YISTLIGLAV TVLMVLVTDY YTAKKYRPVQ SISKASESGH GTNIIMGLSV GMESTFLPIL IIAAGIISSY ILANVYGVAL AATAMLSVAG IIVAIDSFGP VTDNAGGIAE MSDAPEEVRK VTDSLDAVGN TTKAVTKGYA IASAGLAALA LFAGFTQEVA TRFELPDFSA LRGFFDITNP FVLVGLLIGA SIPYLFSSIA MKSVGKAAGA IVDEIRRQFR EIKGIMDGTQ KPDYGKAVDI VTKAALKEMI IPALLPVFFI LVVGLGTKLV ADLAITNPYV GASFTPGTVI AAQALGGLLI GVILSGLFVA ISMTSGGAAW DNGKKYIEDG NFGGKGSDAH KAAVTGDTVG DPYKDTAGPA INPLIKVIMI LALLIVPLL //