ID   A0A1F8DY91_9BACT        Unreviewed;       689 AA.
AC   A0A1F8DY91;
DT   15-FEB-2017, integrated into UniProtKB/TrEMBL.
DT   15-FEB-2017, sequence version 1.
DT   12-AUG-2020, entry version 12.
DE   RecName: Full=K(+)-insensitive pyrophosphate-energized proton pump {ECO:0000256|HAMAP-Rule:MF_01129};
DE            EC=7.1.3.1 {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Membrane-bound proton-translocating pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE   AltName: Full=Pyrophosphate-energized inorganic pyrophosphatase {ECO:0000256|HAMAP-Rule:MF_01129};
DE            Short=H(+)-PPase {ECO:0000256|HAMAP-Rule:MF_01129};
GN   Name=hppA {ECO:0000256|HAMAP-Rule:MF_01129,
GN   ECO:0000313|EMBL:OGM93513.1};
GN   ORFNames=A2935_01400 {ECO:0000313|EMBL:OGM93513.1};
OS   Candidatus Wolfebacteria bacterium RIFCSPLOWO2_01_FULL_47_17b.
OC   Bacteria; Candidatus Wolfebacteria.
OX   NCBI_TaxID=1802558 {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011};
RN   [1] {ECO:0000313|EMBL:OGM93513.1, ECO:0000313|Proteomes:UP000177011}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=27774985; DOI=10.1038/ncomms13219;
RA   Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J.,
RA   Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L.,
RA   Williams K.H., Hubbard S.S., Banfield J.F.;
RT   "Thousands of microbial genomes shed light on interconnected biogeochemical
RT   processes in an aquifer system.";
RL   Nat. Commun. 7:13219-13219(2016).
CC   -!- FUNCTION: Proton pump that utilizes the energy of pyrophosphate
CC       hydrolysis as the driving force for proton movement across the
CC       membrane. Generates a proton motive force. {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate;
CC         Xref=Rhea:RHEA:13973, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:43474; EC=7.1.3.1;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01129};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01129};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129};
CC       Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01129}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the H(+)-translocating pyrophosphatase
CC       (TC 3.A.10) family. K(+)-insensitive subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_01129}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_01129}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OGM93513.1}.
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DR   EMBL; MGIS01000012; OGM93513.1; -; Genomic_DNA.
DR   Proteomes; UP000177011; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0004427; F:inorganic diphosphatase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009678; F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01129; PPase_energized_pump; 1.
DR   InterPro; IPR004131; PPase-energised_H-pump.
DR   PANTHER; PTHR31998; PTHR31998; 1.
DR   Pfam; PF03030; H_PPase; 1.
DR   PIRSF; PIRSF001265; H+-PPase; 1.
DR   TIGRFAMs; TIGR01104; V_PPase; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Hydrogen ion transport {ECO:0000256|HAMAP-Rule:MF_01129};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|HAMAP-Rule:MF_01129};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01129};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW   Rule:MF_01129};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01129}.
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        55..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        79..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        121..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        152..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        224..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        280..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        311..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        354..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        383..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        449..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        487..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        560..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   TRANSMEM        600..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
FT   SITE            443
FT                   /note="Determinant of potassium independence"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_01129"
SQ   SEQUENCE   689 AA;  71703 MW;  9A745303C0EAF5D7 CRC64;
     MQYTNYIIFI PVVLAVAYAA YLMLWLKRQP KGSEKMQEIS KAIRIGARAY LNRQYRTVAI
     VAIVLFVIIW LVFQNWVLGI GFLLGGILSA LAGYIGLNVS VTSNSKTTQA AHTGLGEAMS
     VAFRAGSVTG FLVVALGLLG VAGFYLLTGQ DATALIGFGF GASLISVFAR LGGGIFTKAA
     DVGTDLVGKV EAGIPEDDPR NPGVIADNVG DNVGDCAGMA ADLFETYAVT LTAALLLGAA
     LLTGQQVFFP LVIGGLAIVA SVVGTLFVRL GKKKGIMHAL YKGLGASVIV SAGLFYLAAQ
     QFFPENLWSM YISTLIGLAV TVLMVLVTDY YTAKKYRPVQ SISKASESGH GTNIIMGLSV
     GMESTFLPIL IIAAGIISSY ILANVYGVAL AATAMLSVAG IIVAIDSFGP VTDNAGGIAE
     MSDAPEEVRK VTDSLDAVGN TTKAVTKGYA IASAGLAALA LFAGFTQEVA TRFELPDFSA
     LRGFFDITNP FVLVGLLIGA SIPYLFSSIA MKSVGKAAGA IVDEIRRQFR EIKGIMDGTQ
     KPDYGKAVDI VTKAALKEMI IPALLPVFFI LVVGLGTKLV ADLAITNPYV GASFTPGTVI
     AAQALGGLLI GVILSGLFVA ISMTSGGAAW DNGKKYIEDG NFGGKGSDAH KAAVTGDTVG
     DPYKDTAGPA INPLIKVIMI LALLIVPLL
//