ID A0A1F8DT93_9BACT Unreviewed; 276 AA. AC A0A1F8DT93; DT 15-FEB-2017, integrated into UniProtKB/TrEMBL. DT 15-FEB-2017, sequence version 1. DT 27-NOV-2024, entry version 17. DE RecName: Full=HhH-GPD domain-containing protein {ECO:0000259|SMART:SM00478}; GN ORFNames=A2755_00490 {ECO:0000313|EMBL:OGM91814.1}; OS Candidatus Wolfebacteria bacterium RIFCSPHIGHO2_01_FULL_48_22. OC Bacteria; Candidatus Wolfebacteria. OX NCBI_TaxID=1802555 {ECO:0000313|EMBL:OGM91814.1, ECO:0000313|Proteomes:UP000177029}; RN [1] {ECO:0000313|EMBL:OGM91814.1, ECO:0000313|Proteomes:UP000177029} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=27774985; DOI=10.1038/ncomms13219; RA Anantharaman K., Brown C.T., Hug L.A., Sharon I., Castelle C.J., RA Probst A.J., Thomas B.C., Singh A., Wilkins M.J., Karaoz U., Brodie E.L., RA Williams K.H., Hubbard S.S., Banfield J.F.; RT "Thousands of microbial genomes shed light on interconnected biogeochemical RT processes in an aquifer system."; RL Nat. Commun. 7:13219-13219(2016). CC -!- COFACTOR: CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; CC Evidence={ECO:0000256|ARBA:ARBA00001966}; CC -!- SIMILARITY: Belongs to the Nth/MutY family. CC {ECO:0000256|ARBA:ARBA00008343}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:OGM91814.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MGIP01000006; OGM91814.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1F8DT93; -. DR STRING; 1802555.A2755_00490; -. DR Proteomes; UP000177029; Unassembled WGS sequence. DR GO; GO:0034039; F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; IEA:TreeGrafter. DR GO; GO:0035485; F:adenine/guanine mispair binding; IEA:TreeGrafter. DR GO; GO:0032357; F:oxidized purine DNA binding; IEA:TreeGrafter. DR GO; GO:0000701; F:purine-specific mismatch base pair DNA N-glycosylase activity; IEA:TreeGrafter. DR GO; GO:0006284; P:base-excision repair; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:TreeGrafter. DR CDD; cd00056; ENDO3c; 1. DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1. DR InterPro; IPR011257; DNA_glycosylase. DR InterPro; IPR003265; HhH-GPD_domain. DR InterPro; IPR023170; HhH_base_excis_C. DR InterPro; IPR044298; MIG/MutY. DR PANTHER; PTHR42944; ADENINE DNA GLYCOSYLASE; 1. DR PANTHER; PTHR42944:SF1; ADENINE DNA GLYCOSYLASE; 1. DR Pfam; PF00730; HhH-GPD; 1. DR SMART; SM00478; ENDO3c; 1. DR SUPFAM; SSF48150; DNA-glycosylase; 1. PE 3: Inferred from homology; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW Glycosidase {ECO:0000256|ARBA:ARBA00023295}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Iron {ECO:0000256|ARBA:ARBA00023004}; KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}. FT DOMAIN 54..213 FT /note="HhH-GPD" FT /evidence="ECO:0000259|SMART:SM00478" SQ SEQUENCE 276 AA; 32252 MW; 573069A866F44353 CRC64; MRTAEFQKIV YAHYKKHGRK LPWRIKSGIR GSTSANRGRT SDSIFYRILV SEIMLQQTQV DRVVPKYHEF LKKFPTMRAL ARANRTDVLR AWQGLGYNRR AVWLHEIAKK LTGTHERGST SLRSRLNLAH FARTEELRKL KGIGSNTAAS ICAFAYNMPV IFIETNIRTV FLKYFFPYEK DVSDKDILKL IEKTLDKKNP RTWYWALMDL GSHIKRTEGN FNRTHSKHYA KQSKFEGSRR QLRGKILRDM LQGKKVSLKE KIHKEIAREL AAEGLV //