ID A0A1E3SNM5_MYCIE Unreviewed; 287 AA. AC A0A1E3SNM5; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 28-JUN-2023, entry version 26. DE SubName: Full=Adenylate/guanylate cyclase domain-containing protein {ECO:0000313|EMBL:ORB06851.1}; DE SubName: Full=Cyclase {ECO:0000313|EMBL:ODR03118.1}; GN ORFNames=BHQ20_01635 {ECO:0000313|EMBL:ODR03118.1}, BST27_10610 GN {ECO:0000313|EMBL:ORB06851.1}; OS Mycobacterium intermedium. OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae; OC Mycobacterium; Mycobacterium simiae complex. OX NCBI_TaxID=28445 {ECO:0000313|EMBL:ODR03118.1, ECO:0000313|Proteomes:UP000094976}; RN [1] {ECO:0000313|Proteomes:UP000094976} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HMC2_M5 {ECO:0000313|Proteomes:UP000094976}; RA Greninger A.L., Jerome K.R., Mcnair B., Wallis C., Fang F.; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ODR03118.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HMC2_M5 {ECO:0000313|EMBL:ODR03118.1}; RA Capua I., De Benedictis P., Joannis T., Lombin L.H., Cattoli G.; RL Submitted (SEP-2016) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:ORB06851.1, ECO:0000313|Proteomes:UP000192739} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DSM 44049 {ECO:0000313|EMBL:ORB06851.1, RC ECO:0000313|Proteomes:UP000192739}; RA Tortoli E., Trovato A., Cirillo D.M.; RT "The new phylogeny of genus Mycobacterium."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family. CC {ECO:0000256|ARBA:ARBA00005381}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:ODR03118.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MIHB01000002; ODR03118.1; -; Genomic_DNA. DR EMBL; MVHT01000022; ORB06851.1; -; Genomic_DNA. DR RefSeq; WP_069417348.1; NZ_MVHT01000022.1. DR STRING; 28445.BHQ20_01635; -. DR EnsemblBacteria; ODR03118; ODR03118; BHQ20_01635. DR EnsemblBacteria; OPE45602; OPE45602; BV508_29070. DR EnsemblBacteria; ORB06851; ORB06851; BST27_10610. DR OrthoDB; 9801841at2; -. DR Proteomes; UP000094976; Unassembled WGS sequence. DR Proteomes; UP000192739; Unassembled WGS sequence. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt. DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro. DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro. DR CDD; cd07302; CHD; 1. DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1. DR InterPro; IPR001054; A/G_cyclase. DR InterPro; IPR029787; Nucleotide_cyclase. DR PANTHER; PTHR43081:SF1; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC; 1. DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1. DR Pfam; PF00211; Guanylate_cyc; 1. DR SMART; SM00044; CYCc; 1. DR SUPFAM; SSF55073; Nucleotide cyclase; 1. DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 6..27 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 113..225 FT /note="Guanylate cyclase" FT /evidence="ECO:0000259|PROSITE:PS50125" FT REGION 40..60 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 287 AA; 31324 MW; 7FD9B75675B50B74 CRC64; MSAAVWWAIV AVVEFGGLVA VGTVLIVSRR QLASTRLALE RAKQEKSKPR PRRPRPRRPG VAPLAIKTVW ETADSLINKG IGATVRNSFE DLAGWARVER PDLARMVADG DVVIAFSDIE RSTELNEKLG DLGWVKLLER HNKLINKQVE AHGGHVIKTQ GDGFMMAFPD PAQAVRCSIA IQRALQADPE RWENIRVRMG LHVGSSVRRG DDLFGRNVAM AARVAGQAKG GEILVSEAIR EAIAHAGEIA LGPQREVELK GLSGMHEIYP VVVMPAPLAL DAPREQT //