ID A0A1E1G7K4_GRUNI Unreviewed; 173 AA. AC A0A1E1G7K4; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 05-DEC-2018, entry version 5. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:BAV78730.1}; OS Grus nigricollis (Black-necked crane). OG Mitochondrion {ECO:0000313|EMBL:BAV78730.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Grus. OX NCBI_TaxID=40817 {ECO:0000313|EMBL:BAV78730.1}; RN [1] {ECO:0000313|EMBL:BAV78730.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27693570; DOI=10.1016/j.ympev.2016.09.026; RA Akiyama T., Nishida C., Momose K., Onuma M., Takami K., Masuda R.; RT "Gene duplication and concerted evolution of mitochondrial DNA in RT crane species."; RL Mol. Phylogenet. Evol. 106:158-163(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00585382}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC114480; BAV78730.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00477717}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, KW ECO:0000313|EMBL:BAV78730.1}; KW NAD {ECO:0000256|RuleBase:RU004430, ECO:0000256|SAAS:SAAS00119311}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00119307}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430, KW ECO:0000256|SAAS:SAAS00119309}; KW Transport {ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1 20 {ECO:0000256|SAM:SignalP}. FT CHAIN 21 173 NADH-ubiquinone oxidoreductase chain 6. FT {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009113604. FT TRANSMEM 30 46 Helical. {ECO:0000256|RuleBase:RU004430}. FT TRANSMEM 53 75 Helical. {ECO:0000256|RuleBase:RU004430}. FT TRANSMEM 87 108 Helical. {ECO:0000256|RuleBase:RU004430}. FT TRANSMEM 143 162 Helical. {ECO:0000256|RuleBase:RU004430}. SQ SEQUENCE 173 AA; 18350 MW; 15483246FF65A5A2 CRC64; MTYFVLFMGL CFVLGGLAVA SNPSPYYGVV GLVLASVVGC GWLLSLGVSF VSLVLFMVYL GGMLVVFVYS VSLAADPYPE AWGDWRVVGY IVGLVLVLVM GVVVGGVVEC WNFGVVTVDS GGMLSVRLDF SGVAMFYSRG AGLFLMAGWG LLLTLFVVLE LVRGLSRGPI RPV //