ID A0A1E1G7K4_GRUNI Unreviewed; 173 AA. AC A0A1E1G7K4; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 24-JUL-2024, entry version 18. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|ARBA:ARBA00021095, ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:BAV78730.1}; OS Grus nigricollis (Black-necked crane). OG Mitochondrion {ECO:0000313|EMBL:BAV78730.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Grus. OX NCBI_TaxID=40817 {ECO:0000313|EMBL:BAV78730.1}; RN [1] {ECO:0000313|EMBL:BAV78730.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27693570; DOI=10.1016/j.ympev.2016.09.026; RA Akiyama T., Nishida C., Momose K., Onuma M., Takami K., Masuda R.; RT "Gene duplication and concerted evolution of mitochondrial DNA in crane RT species."; RL Mol. Phylogenet. Evol. 106:158-163(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC membrane {ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|ARBA:ARBA00005698, ECO:0000256|RuleBase:RU004430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC114480; BAV78730.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1E1G7K4; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.120.1200; NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ; 1. DR InterPro; IPR050269; ComplexI_Subunit6. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ. DR PANTHER; PTHR11435; NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6; 1. DR PANTHER; PTHR11435:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|RuleBase:RU004430}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:BAV78730.1}; KW NAD {ECO:0000256|RuleBase:RU004430}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|RuleBase:RU004430}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..173 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5009113604" FT TRANSMEM 30..46 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 53..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 87..108 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 143..162 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" SQ SEQUENCE 173 AA; 18350 MW; 15483246FF65A5A2 CRC64; MTYFVLFMGL CFVLGGLAVA SNPSPYYGVV GLVLASVVGC GWLLSLGVSF VSLVLFMVYL GGMLVVFVYS VSLAADPYPE AWGDWRVVGY IVGLVLVLVM GVVVGGVVEC WNFGVVTVDS GGMLSVRLDF SGVAMFYSRG AGLFLMAGWG LLLTLFVVLE LVRGLSRGPI RPV //