ID A0A1E1G7K4_GRUNI Unreviewed; 173 AA. AC A0A1E1G7K4; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 12-AUG-2020, entry version 10. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:BAV78730.1}; OS Grus nigricollis (Black-necked crane). OG Mitochondrion {ECO:0000313|EMBL:BAV78730.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Gruiformes; Gruidae; Grus. OX NCBI_TaxID=40817 {ECO:0000313|EMBL:BAV78730.1}; RN [1] {ECO:0000313|EMBL:BAV78730.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27693570; DOI=10.1016/j.ympev.2016.09.026; RA Akiyama T., Nishida C., Momose K., Onuma M., Takami K., Masuda R.; RT "Gene duplication and concerted evolution of mitochondrial DNA in crane RT species."; RL Mol. Phylogenet. Evol. 106:158-163(2017). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00002539, ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC membrane {ECO:0000256|ARBA:ARBA00004225, CC ECO:0000256|RuleBase:RU004430}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|ARBA:ARBA00005698, ECO:0000256|RuleBase:RU004430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC114480; BAV78730.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.120.1200; -; 1. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR InterPro; IPR042106; Nuo/plastoQ_OxRdtase_6_NuoJ. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004430}; KW Mitochondrion {ECO:0000256|RuleBase:RU004430, ECO:0000313|EMBL:BAV78730.1}; KW NAD {ECO:0000256|RuleBase:RU004430}; KW Respiratory chain {ECO:0000256|RuleBase:RU004430}; KW Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004430}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU004430}; Transport {ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1..20 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 21..173 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5009113604" FT TRANSMEM 30..46 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 53..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 87..108 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 143..162 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" SQ SEQUENCE 173 AA; 18350 MW; 15483246FF65A5A2 CRC64; MTYFVLFMGL CFVLGGLAVA SNPSPYYGVV GLVLASVVGC GWLLSLGVSF VSLVLFMVYL GGMLVVFVYS VSLAADPYPE AWGDWRVVGY IVGLVLVLVM GVVVGGVVEC WNFGVVTVDS GGMLSVRLDF SGVAMFYSRG AGLFLMAGWG LLLTLFVVLE LVRGLSRGPI RPV //