ID A0A1D8I1N4_SOUCH Unreviewed; 500 AA. AC A0A1D8I1N4; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 13-FEB-2019, entry version 7. DE SubName: Full=Hepatic lipase {ECO:0000313|EMBL:AOT98812.1}; DE Flags: Fragment; GN Name=LIPC {ECO:0000313|EMBL:AOT98812.1}; OS Sousa chinensis (Indo-pacific humpbacked dolphin) (Steno chinensis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Cetacea; OC Odontoceti; Delphinidae; Sousa. OX NCBI_TaxID=103600 {ECO:0000313|EMBL:AOT98812.1}; RN [1] {ECO:0000313|EMBL:AOT98812.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27651393; RA Wang Z., Xu S., Du K., Huang F., Chen Z., Zhou K., Ren W., Yang G.; RT "Evolution of Digestive Enzymes and RNASE1 Provides Insights into RT Dietary Switch of Cetaceans."; RL Mol. Biol. Evol. 0:0-0(2016). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase CC family. {ECO:0000256|RuleBase:RU004262, CC ECO:0000256|SAAS:SAAS00591292}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX057402; AOT98812.1; -; mRNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR CDD; cd00707; Pancreat_lipase_like; 1. DR Gene3D; 3.40.50.1820; -; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase/vitellogenin. DR InterPro; IPR002333; Lipase_hep. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR033906; Lipase_N. DR InterPro; IPR001024; PLAT/LH2_dom. DR InterPro; IPR036392; PLAT/LH2_dom_sf. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; PTHR11610; 1. DR PANTHER; PTHR11610:SF2; PTHR11610:SF2; 1. DR Pfam; PF00151; Lipase; 1. DR Pfam; PF01477; PLAT; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1. DR PRINTS; PR00824; HEPLIPASE. DR PRINTS; PR00821; TAGLIPASE. DR SMART; SM00308; LH2; 1. DR SUPFAM; SSF49723; SSF49723; 1. DR SUPFAM; SSF53474; SSF53474; 1. DR PROSITE; PS50095; PLAT; 1. PE 2: Evidence at transcript level; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Secreted {ECO:0000256|SAAS:SAAS00439306}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 21 {ECO:0000256|SAM:SignalP}. FT CHAIN 22 500 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5009107646. FT DOMAIN 353 487 PLAT. {ECO:0000259|PROSITE:PS50095}. FT ACT_SITE 168 168 Nucleophile. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT ACT_SITE 194 194 Charge relay system. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT ACT_SITE 279 279 Charge relay system. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT METAL 208 208 Calcium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000865-2}. FT METAL 213 213 Calcium. {ECO:0000256|PIRSR:PIRSR000865- FT 2}. FT NON_TER 500 500 {ECO:0000313|EMBL:AOT98812.1}. SQ SEQUENCE 500 AA; 56548 MW; 1E9226054C1F5AF7 CRC64; MENSLCVSIF LVLCIFIQSS AHGQSLGLES FGRRSRAAET KETLQETRTR FLLFKEETNK GCQIRLNHSD TLQQCGFNSS LPLVMIVHGW LMEASLENWI WQMVAALKSQ VARPVNVGLA EWVTLAHTHY SIAVRNTRLV GQEIAALLQW LEESVHFSPS NVHLIGYSLG AHVSGFAGSY MSRKHKVGRI TGLDAAGLLF KRASPSDRLS PDDANFVDAI HTFTQEHMGL SVGIKQPIAH YDFYPNGGSY QPGCHFLELY KHIAKHGLNA ITQAIKCAHE RSVHLFIDSL LHADMQSTAY PCRDMDSFSQ GLCLSCKKGR CNTLGYYARQ EPQSKKSKSL FLVTRAQSPF KVYHYQLKIQ FSNEIEKPAE PTFAMSLLGT KEEMQKIPIT LNKGITSNKT YSFLITLDLD IGELIMTKFK WENSLVWSNV WNTVQTIIPW GRESLHSGLV LKSIRVKAGE TQQRMTFCSE NMNDLQLHPT QEKTFVRCES NSKKLKRKIR //