ID A0A1D5RMJ8_MOUSE Unreviewed; 2369 AA. AC A0A1D5RMJ8; DT 30-NOV-2016, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 1. DT 24-JAN-2024, entry version 42. DE SubName: Full=CCR4-NOT transcription complex, subunit 1 {ECO:0000313|Ensembl:ENSMUSP00000148807.2}; GN Name=Cnot1 {ECO:0000313|Ensembl:ENSMUSP00000148807.2, GN ECO:0000313|MGI:MGI:2442402}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000148807.2, ECO:0000313|Proteomes:UP000000589}; RN [1] {ECO:0000313|Ensembl:ENSMUSP00000148807.2, ECO:0000313|Proteomes:UP000000589} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148807.2, RC ECO:0000313|Proteomes:UP000000589}; RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112; RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., RA Eichler E.E., Ponting C.P.; RT "Lineage-specific biology revealed by a finished genome assembly of the RT mouse."; RL PLoS Biol. 7:E1000112-E1000112(2009). RN [2] {ECO:0007829|PubMed:21183079} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001; RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R., RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.; RT "A tissue-specific atlas of mouse protein phosphorylation and expression."; RL Cell 143:1174-1189(2010). RN [3] {ECO:0000313|Ensembl:ENSMUSP00000148807.2} RP IDENTIFICATION. RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000148807.2}; RG Ensembl; RL Submitted (JUL-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the CNOT1 family. CC {ECO:0000256|ARBA:ARBA00025717}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; NP_001192155.1; NM_001205226.1. DR SMR; A0A1D5RMJ8; -. DR ProteomicsDB; 359111; -. DR Antibodypedia; 29121; 107 antibodies from 21 providers. DR Ensembl; ENSMUST00000211887.2; ENSMUSP00000148807.2; ENSMUSG00000036550.17. DR GeneID; 234594; -. DR AGR; MGI:2442402; -. DR CTD; 23019; -. DR MGI; MGI:2442402; Cnot1. DR VEuPathDB; HostDB:ENSMUSG00000036550; -. DR GeneTree; ENSGT00390000014869; -. DR OrthoDB; 1329322at2759; -. DR BioGRID-ORCS; 234594; 23 hits in 81 CRISPR screens. DR ChiTaRS; Cnot1; mouse. DR Proteomes; UP000000589; Chromosome 8. DR Bgee; ENSMUSG00000036550; Expressed in embryonic post-anal tail and 125 other cell types or tissues. DR ExpressionAtlas; A0A1D5RMJ8; baseline and differential. DR GO; GO:0030015; C:CCR4-NOT core complex; IEA:InterPro. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0017148; P:negative regulation of translation; IEA:InterPro. DR CDD; cd20710; NOT1_connector; 1. DR Gene3D; 1.25.40.180; -; 1. DR Gene3D; 1.25.40.790; -; 1. DR Gene3D; 1.25.40.800; -; 1. DR Gene3D; 1.25.40.840; CCR4-NOT transcription complex subunit 1 TTP binding domain; 1. DR InterPro; IPR007196; CCR4-Not_Not1_C. DR InterPro; IPR032191; CNOT1_CAF1_bind. DR InterPro; IPR024557; CNOT1_dom_4. DR InterPro; IPR032194; CNOT1_HEAT. DR InterPro; IPR032193; CNOT1_TTP_bind. DR InterPro; IPR038535; CNOT1_TTP_bind_sf. DR InterPro; IPR040398; Not1. DR PANTHER; PTHR13162; CCR4-NOT TRANSCRIPTION COMPLEX; 1. DR PANTHER; PTHR13162:SF8; CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1; 1. DR Pfam; PF16415; CNOT1_CAF1_bind; 1. DR Pfam; PF16418; CNOT1_HEAT; 1. DR Pfam; PF16417; CNOT1_TTP_bind; 1. DR Pfam; PF12842; DUF3819; 1. DR Pfam; PF04054; Not1; 1. PE 1: Evidence at protein level; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Proteomics identification {ECO:0007829|EPD:A0A1D5RMJ8, KW ECO:0007829|MaxQB:A0A1D5RMJ8}; KW Reference proteome {ECO:0000313|Proteomes:UP000000589}; KW Repressor {ECO:0000256|ARBA:ARBA00022491}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 498..654 FT /note="CCR4-NOT transcription complex subunit 1 HEAT FT repeat" FT /evidence="ECO:0000259|Pfam:PF16418" FT DOMAIN 815..995 FT /note="CCR4-NOT transcription complex subunit 1 TTP FT binding" FT /evidence="ECO:0000259|Pfam:PF16417" FT DOMAIN 1081..1304 FT /note="CCR4-NOT transcription complex subunit 1 CAF1- FT binding" FT /evidence="ECO:0000259|Pfam:PF16415" FT DOMAIN 1380..1527 FT /note="CCR4-NOT transcription complex subunit 1" FT /evidence="ECO:0000259|Pfam:PF12842" FT DOMAIN 1992..2350 FT /note="CCR4-Not complex component Not1 C-terminal" FT /evidence="ECO:0000259|Pfam:PF04054" FT REGION 723..766 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1308..1345 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1322..1345 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2369 AA; 266120 MW; C2D065AACCEEE072 CRC64; MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD GKSSGKDFHQ FLIQECASLI TKPNFISTLS YAIDNPLHYQ KSLKPAPHLF AQLSKVLKLS KVQEVIFGLA LLNSSSPDLR GFAAQFIKQK LPDLLRSYID ADVSGNQEGG FQDIAIEVLH LLLSHLLFGQ KGAFGVGQEQ IDAFLKTLRR DFPQERCPVV LAPLLYPEKR DILMDRILPD SGGVAKTMME SSLADFMQEV GYGFCASIEE CRNIIMQFGV REVTAAQVAR VLGMMARTHS GLTDGIPLQS ISAPGSGIWS DGKDKSEGAQ AHTWNVEVLI DVLKELNPSL NFKEVTYELD HPGFQIRDSK GLHNVVYGIQ RGLGMEVFPV DFIYRPWKHA EGQLSFIQHS LINPEVFCFA DYPCHTVATD ILKAPPEDDN REIATWKSLD LIESLLRLAE VGQYEQVKQL FSFPIKHCPD MLVLALLQIN TSWHTLRHEL ISTLMPIFLG NHPNSAIILH YAWHGQGQSP SIRQLIMHAM AEWYMRGEQY DQAKLSRILD VAQDLKALSM LLNGTPFAFV IDLAALASRR EYLKLDKWLT DKIREHGEPF IQACMTFLKR RCPSILGGLA PEKDQPKSAQ LPAETLATML ACLQACAGSV SQELSETILT MVANCSNVMN KARQPPPGVM PKGRPPSASS LDAISPVQID PLAGMASLSI GGSAAPHTQS MQGFPPNLGS AFSTPQSPAK AFPPLSTPNQ TTAFSGIGGL SSQLPVGGLG TGSLTGIGTG ALGLPAVNND PFVQRKLGTS GLNQPTFQQT DLSQVWPEAN QHFSKEIDDE ANSYFQRIYN HPPHPTMSVD EVLEMLQRFK DSTIKREREV FNCMLRNLFE EYRFFPQYPD KELHITACLF GGIIEKGLVT YMALGLALRY VLEALRKPFG SKMYYFGIAA LDRFKNRLKD YPQYCQHLAS ISHFMQFPHH LQEYIEYGQQ SRDPPVKMQG SITTPGSIAL AQAQAQAQVP AKAPLAGQVN TMVTTSTTTT VAKTVTVTKP TGVSFKKDVP PSINTTNIDT LLVATDQTER IVEPPENIQE KIAFIFNNLS QSNMTQKVEE LKETVKEEFM PWVSQYLVMK RVSIEPNFHS LYSNFLDTLK NPEFNKMVLN ETYRNIKVLL TSDKAAANFS DRSLLKNLGH WLGMITLAKN KPILHTDLDV KSLLLEAYVK GQQELLYVVP FVAKVLESSI RSLVFRPPNP WTMAIMNVLA ELHQEHDLKL NLKFEIEVLC KNLALDINEL KPGNLLKDKD RLKNLDEQLS APKKDVKQPE ELPAITTTTT STTPATSTTC TATVPPQPQY SYHDINVYSL AGLAPHITLN PTIPLFQAHP QLKQCVRQAI ERAVQELVHP VVDRSIKIAM TTCEQIVRKD FALDSEESRM RIAAHHMMRN LTAGMAMITC REPLLMSIST NLKNSFASAL RTASPQQREM MDQAAAQLAQ DNCELACCFI QKTAVEKAGP EMDKRLATEF ELRKHARQEG RRYCDPVVLT YQAERMPEQI RLKVGGVDPK QLAVYEEFAR NVPGFLPTND LSQPTGFLAQ PMKQAWATDD VAQIYDKCIT ELEQHLHAIP PTLAMNPQAQ ALRSLLEVVV LSRNSRDAIA ALGLLQKAVE GLLDATSGAD ADLLLRYREC HLLVLKALQD GRAYGSPWCN KQITRCLIEC RDEYKYNVEA VELLIRNHLV NMQQYDLHLA QSMENGLNYM AVAFAMQLVK ILLVDERSVA HITEADLFHT IETLMRINAH SRGNAPEGLP QLMEVVRSNY EAMIDRAHGG PNFMMHSGIS QASEYDDPPG LREKAEYLLR EWVNLYHSAA AGRDSTKAFS AFVGQMHQQG ILKTDDLITR FFRLCTEMCV EISYRAQAEQ QHNPAANPTM IRAKCYHNLD AFVRLIALLV KHSGEATNTV TKINLLNKVL GIVVGVLLQD HDVRQSEFQQ LPYHRIFIML LLELNAPEHV LETINFQTLT AFCNTFHILR PTKAPGFVYA WLELISHRIF IARMLAHTPQ QKGWPMYAQL LIDLFKYLAP FLRNVELTKP MQILYKGTLR VLLVLLHDFP EFLCDYHYGF CDVIPPNCIQ LRNLILSAFP RNMRLPDPFT PNLKVDMLSE INIAPRILTN FTGVMPPQFK KDLDSYLKTR SPVTFLSDLR SNLQVSNEPG NRYNLQLINA LVLYVGTQAI AHIHNKGSTP SMSTITHSAH MDIFQNLAVD LDTEGRYLFL NAIANQLRYP NSHTHYFSCT MLYLFAEANT EAIQEQITRV LLERLIVNRP HPWGLLITFI ELIKNPAFKF WNHEFVHCAP EIEKLFQSVA QCCMGQKQAQ QVMEGTGAS //