ID A0A1C8Z3U5_9INFA Unreviewed; 498 AA. AC A0A1C8Z3U5; DT 30-NOV-2016, integrated into UniProtKB/TrEMBL. DT 30-NOV-2016, sequence version 1. DT 31-JAN-2018, entry version 8. DE RecName: Full=Nucleoprotein {ECO:0000256|HAMAP-Rule:MF_04070}; DE AltName: Full=Nucleocapsid protein {ECO:0000256|HAMAP-Rule:MF_04070}; DE Short=Protein N {ECO:0000256|HAMAP-Rule:MF_04070}; GN Name=NP {ECO:0000256|HAMAP-Rule:MF_04070, GN ECO:0000256|RuleBase:RU361251, ECO:0000313|EMBL:AOK93178.1}; OS Influenza A virus (A/duck/Zhejiang/6DK19-MA/2013(H5N2)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=1891312 {ECO:0000313|EMBL:AOK93178.1}; RN [1] {ECO:0000313|EMBL:AOK93178.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/duck/Zhejiang/6DK19-MA/2013 {ECO:0000313|EMBL:AOK93178.1}; RX PubMed=27663652; RA Wu H., Peng X., Peng X., Wu N.; RT "Amino acid substitutions involved in the adaptation of a novel highly RT pathogenic H5N2 avian influenza virus in mice."; RL Virol. J. 13:159-159(2016). CC -!- SUBCELLULAR LOCATION: Host nucleus CC {ECO:0000256|SAAS:SAAS00966152}. CC -!- PTM: Late in virus-infected cells, may be cleaved from a 56-kDa CC protein to a 53-kDa protein by a cellular caspase. This cleavage CC might be a marker for the onset of apoptosis in infected cells or CC have a specific function in virus host interaction. CC {ECO:0000256|HAMAP-Rule:MF_04070}. CC -!- SIMILARITY: Belongs to the influenza viruses nucleoprotein family. CC {ECO:0000256|HAMAP-Rule:MF_04070, ECO:0000256|RuleBase:RU361251, CC ECO:0000256|SAAS:SAAS00966161}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX714307; AOK93178.1; -; Viral_cRNA. DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-UniRule. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-UniRule. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule. DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW. DR GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-UniRule. DR HAMAP; MF_04070; INFV_NCAP; 1. DR InterPro; IPR002141; Flu_NP. DR Pfam; PF00506; Flu_NP; 1. PE 3: Inferred from homology; KW Capsid protein {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|RuleBase:RU361251, ECO:0000256|SAAS:SAAS00966151}; KW Helical capsid protein {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966174}; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|RuleBase:RU361251, ECO:0000256|SAAS:SAAS00966147}; KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966156}; KW Ribonucleoprotein {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966134}; KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966163}; KW Viral nucleoprotein {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|RuleBase:RU361251, ECO:0000313|EMBL:AOK93178.1}; KW Viral penetration into host nucleus {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966166}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|RuleBase:RU361251, ECO:0000256|SAAS:SAAS00966164}; KW Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04070, KW ECO:0000256|SAAS:SAAS00966165}. FT MOTIF 1 18 Unconventional nuclear localization FT signal. {ECO:0000256|HAMAP-Rule: FT MF_04070}. FT MOTIF 198 216 Bipartite nuclear localization signal. FT {ECO:0000256|HAMAP-Rule:MF_04070}. SQ SEQUENCE 498 AA; 56325 MW; F5AAE38C8A664DA8 CRC64; MASQGTKRSY EQMETGGERQ NATEIRASVG RMISGIGRFY IQMCTELKLS DHEGRLIQNS ITIERMVLSA FDERRNRYLE EHPSAGKDPK KTGGPIYRRR DGKWMRELIL YDKQEIRRIW RQANNGEDAT AGLTHLMIWH SNLNDATYQR TRALVRTGMD PRMCSLMQGS TLPRRSGAAG AAVKGVGTMV MELIRMIKRG INDRNFWRGE NGRRTRIAYE RMCNILKGKF QTAAQRAMMD QVRESRNPGN AEIEDLIFLA RSALILRGSV AHKSCLPACV YGLAVASGYD FEREGYSLVG IDPFRLLQNS QVFSLIRPNE NPAHKSQLVW MACHSAAFED LRVSSFIRGT RVVPRGQLST RGVQIASNEN METMDSNTLE LRSRYWAIRT RSGGNTNQQR ASAGQISVQP TFSVQRNLPF ERATIMAAFA GNTEGRTSDM RTEIIRMMES AKPEDVSFQG RGVFELSDEK ATNPIVPSFD MNNEGSYFFG DNAEEYDN //