ID A0A1C3PI26_HUMAN Unreviewed; 258 AA. AC A0A1C3PI26; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 03-MAY-2023, entry version 35. DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:SBW38664.1}; GN Name=HLA-DPB1 {ECO:0000313|EMBL:SBW38664.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:SBW38664.1}; RN [1] {ECO:0000313|EMBL:SBW38664.1} RP NUCLEOTIDE SEQUENCE. RA Lang K., Schoefl G., Schmidt A., Lange V.; RT "Complementing the HLA-DPB1 Database: Full-Length Gene Characterization of RT all Common and Well-Documented Alleles."; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:SBW38664.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V.; RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LT599443; SBW38664.1; -; Genomic_DNA. DR EMBL; LT599444; SBW38665.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1C3PI26; -. DR SMR; A0A1C3PI26; -. DR PeptideAtlas; A0A1C3PI26; -. DR ChiTaRS; HLA-DPB1; human. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR CDD; cd21003; IgC1_MHC_II_beta_HLA-DP; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF46; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DP BETA 1 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 4: Predicted; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|SAM:Phobius}; MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..29 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 30..258 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5013492587" FT TRANSMEM 227..246 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 124..212 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 258 AA; 29390 MW; 4203ABCAAF80F700 CRC64; MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYVYQL RQECYAFNGT QRFLERYIYN REEFVRFDSD VGEFRAVTEL GRPDEDYWNS QKDLLEEERA VPDRVCRHNY ELDEAVTLQR RVQPKVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW TFQILVMLEM TPQQGDVYIC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFMLGLIIC GVGIFMHRRS KKVQRGSA //