ID A0A1B4Z9I8_CRODS Unreviewed; 188 AA. AC A0A1B4Z9I8; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 24-JUL-2024, entry version 20. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; DE Flags: Fragment; GN Name=BDNF {ECO:0000313|EMBL:BAV56090.1}; OS Crocidura dsinezumi (Dsinezumi shrew) (Japanese white-toothed shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Crocidurinae; Crocidura. OX NCBI_TaxID=62277 {ECO:0000313|EMBL:BAV56090.1}; RN [1] {ECO:0000313|EMBL:BAV56090.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27498968; DOI=10.1038/srep31173; RA Sato J.J., Ohdachi S.D., Echenique-Diaz L.M., Borroto-Paez R., RA Begue-Quiala G., Delgado-Labanino J.L., Gamez-Diez J., Alvarez-Lemus J., RA Nguyen S.T., Yamaguchi N., Kita M.; RT "Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic over- RT water dispersal origin for the Cuban solenodon."; RL Sci. Rep. 6:31173-31173(2016). CC -!- FUNCTION: During development, promotes the survival and differentiation CC of selected neuronal populations of the peripheral and central nervous CC systems. Participates in axonal growth, pathfinding and in the CC modulation of dendritic growth and morphology. Major regulator of CC synaptic transmission and plasticity at adult synapses in many regions CC of the CNS. {ECO:0000256|RuleBase:RU364086}. CC -!- FUNCTION: Important signaling molecule that activates signaling CC cascades downstream of NTRK2 (By similarity). During development, CC promotes the survival and differentiation of selected neuronal CC populations of the peripheral and central nervous systems. Participates CC in axonal growth, pathfinding and in the modulation of dendritic growth CC and morphology. Major regulator of synaptic transmission and plasticity CC at adult synapses in many regions of the CNS. The versatility of BDNF CC is emphasized by its contribution to a range of adaptive neuronal CC responses including long-term potentiation (LTP), long-term depression CC (LTD), certain forms of short-term synaptic plasticity, as well as CC homeostatic regulation of intrinsic neuronal excitability. CC {ECO:0000256|ARBA:ARBA00025383}. CC -!- SUBUNIT: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB. CC Can form heterodimers with other neurotrophin family members, such as CC NTF3 and NTF4 (in vitro), but the physiological relevance of this is CC not clear (By similarity). BDNF precursor form: interacts with the CC heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower CC affinity for the heterodimer formed by NGFR and SORCS2. CC {ECO:0000256|ARBA:ARBA00025882}. CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. CC {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC124895; BAV56090.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1B4Z9I8; -. DR GO; GO:0030424; C:axon; IEA:TreeGrafter. DR GO; GO:0030425; C:dendrite; IEA:TreeGrafter. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0008021; C:synaptic vesicle; IEA:TreeGrafter. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005163; F:nerve growth factor receptor binding; IEA:TreeGrafter. DR GO; GO:0007169; P:cell surface receptor protein tyrosine kinase signaling pathway; IEA:TreeGrafter. DR GO; GO:0007613; P:memory; IEA:TreeGrafter. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:TreeGrafter. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:TreeGrafter. DR GO; GO:0021675; P:nerve development; IEA:TreeGrafter. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IEA:TreeGrafter. DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:TreeGrafter. DR GO; GO:0007422; P:peripheral nervous system development; IEA:TreeGrafter. DR GO; GO:0048672; P:positive regulation of collateral sprouting; IEA:TreeGrafter. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:TreeGrafter. DR GO; GO:0045664; P:regulation of neuron differentiation; IEA:TreeGrafter. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR PANTHER; PTHR11589:SF3; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS50270; NGF_2; 1. PE 3: Inferred from homology; KW Growth factor {ECO:0000256|RuleBase:RU364086}. FT DOMAIN 124..188 FT /note="Nerve growth factor-related" FT /evidence="ECO:0000259|SMART:SM00140" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAV56090.1" FT NON_TER 188 FT /evidence="ECO:0000313|EMBL:BAV56090.1" SQ SEQUENCE 188 AA; 20867 MW; 7969EE35F11640BC CRC64; ISYFGCMKAA PMKEANIRGQ GSLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKARP HEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR //