ID A0A1B4Z9I8_CRODS Unreviewed; 188 AA. AC A0A1B4Z9I8; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 11-DEC-2019, entry version 12. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; DE Flags: Fragment; GN Name=BDNF {ECO:0000313|EMBL:BAV56090.1}; OS Crocidura dsinezumi (Dsinezumi shrew) (Japanese white-toothed shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; Crocidurinae; Crocidura. OX NCBI_TaxID=62277 {ECO:0000313|EMBL:BAV56090.1}; RN [1] {ECO:0000313|EMBL:BAV56090.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27498968; DOI=10.1038/srep31173; RA Sato J.J., Ohdachi S.D., Echenique-Diaz L.M., Borroto-Paez R., RA Begue-Quiala G., Delgado-Labanino J.L., Gamez-Diez J., Alvarez-Lemus J., RA Nguyen S.T., Yamaguchi N., Kita M.; RT "Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic over- RT water dispersal origin for the Cuban solenodon."; RL Sci. Rep. 6:31173-31173(2016). CC -!- FUNCTION: During development, promotes the survival and differentiation CC of selected neuronal populations of the peripheral and central nervous CC systems. Participates in axonal growth, pathfinding and in the CC modulation of dendritic growth and morphology. Major regulator of CC synaptic transmission and plasticity at adult synapses in many regions CC of the CNS. {ECO:0000256|RuleBase:RU364086}. CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. CC {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|RuleBase:RU364086, ECO:0000256|SAAS:SAAS00543519}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC124895; BAV56090.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00426825}; KW Growth factor {ECO:0000256|RuleBase:RU364086, KW ECO:0000256|SAAS:SAAS00160138}. FT DOMAIN 124..188 FT /note="NGF" FT /evidence="ECO:0000259|SMART:SM00140" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:BAV56090.1" FT NON_TER 188 FT /evidence="ECO:0000313|EMBL:BAV56090.1" SQ SEQUENCE 188 AA; 20867 MW; 7969EE35F11640BC CRC64; ISYFGCMKAA PMKEANIRGQ GSLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKARP HEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR //