ID A0A1B4Z9I8_CRODS Unreviewed; 188 AA. AC A0A1B4Z9I8; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 08-MAY-2019, entry version 10. DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086}; DE Short=BDNF {ECO:0000256|RuleBase:RU364086}; DE Flags: Fragment; GN Name=BDNF {ECO:0000313|EMBL:BAV56090.1}; OS Crocidura dsinezumi (Dsinezumi shrew) (Japanese white-toothed shrew). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Soricidae; OC Crocidurinae; Crocidura. OX NCBI_TaxID=62277 {ECO:0000313|EMBL:BAV56090.1}; RN [1] {ECO:0000313|EMBL:BAV56090.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27498968; DOI=10.1038/srep31173; RA Sato J.J., Ohdachi S.D., Echenique-Diaz L.M., Borroto-Paez R., RA Begue-Quiala G., Delgado-Labanino J.L., Gamez-Diez J., RA Alvarez-Lemus J., Nguyen S.T., Yamaguchi N., Kita M.; RT "Molecular phylogenetic analysis of nuclear genes suggests a Cenozoic RT over-water dispersal origin for the Cuban solenodon."; RL Sci. Rep. 6:31173-31173(2016). CC -!- FUNCTION: During development, promotes the survival and CC differentiation of selected neuronal populations of the peripheral CC and central nervous systems. Participates in axonal growth, CC pathfinding and in the modulation of dendritic growth and CC morphology. Major regulator of synaptic transmission and CC plasticity at adult synapses in many regions of the CNS. CC {ECO:0000256|RuleBase:RU364086}. CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. CC {ECO:0000256|RuleBase:RU364086}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}. CC -!- SIMILARITY: Belongs to the NGF-beta family. CC {ECO:0000256|RuleBase:RU364086, ECO:0000256|SAAS:SAAS00543519}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LC124895; BAV56090.1; -; Genomic_DNA. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR Gene3D; 2.10.90.10; -; 1. DR InterPro; IPR020430; Brain-der_neurotrophic_factor. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR PANTHER; PTHR11589; PTHR11589; 1. DR PANTHER; PTHR11589:SF3; PTHR11589:SF3; 1. DR Pfam; PF00243; NGF; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01912; BDNFACTOR. DR PRINTS; PR00268; NGF. DR ProDom; PD002052; Nerve_growth_factor-rel; 1. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; SSF57501; 1. PE 3: Inferred from homology; KW Disulfide bond {ECO:0000256|SAAS:SAAS00426825}; KW Growth factor {ECO:0000256|RuleBase:RU364086, KW ECO:0000256|SAAS:SAAS00160138}. FT DOMAIN 124 188 NGF. {ECO:0000259|SMART:SM00140}. FT NON_TER 1 1 {ECO:0000313|EMBL:BAV56090.1}. FT NON_TER 188 188 {ECO:0000313|EMBL:BAV56090.1}. SQ SEQUENCE 188 AA; 20867 MW; 7969EE35F11640BC CRC64; ISYFGCMKAA PMKEANIRGQ GSLAYPGVRT HGTLESVNGP KAGSRGLTSL ADTFEHVIEE LLDEDQKARP HEENNKDADL YTSRVMLSSQ VPLEPPLLFL LEEYKNYLDA ANMSMRVRRH SDPARRGELS VCDSISEWVT AADKKTAVDM SGGTVTVLEK VPVSKGQLKQ YFYETKCNPM GYTKEGCR //