ID A0A1B4K161_BURTH Unreviewed; 246 AA. AC A0A1B4K161; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 10-FEB-2021, entry version 26. DE RecName: Full=Probable acetoacetate decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597}; DE Short=AAD {ECO:0000256|HAMAP-Rule:MF_00597}; DE Short=ADC {ECO:0000256|HAMAP-Rule:MF_00597}; DE EC=4.1.1.4 {ECO:0000256|HAMAP-Rule:MF_00597}; GN Name=adc {ECO:0000256|HAMAP-Rule:MF_00597}; GN ORFNames=A8H37_03860 {ECO:0000313|EMBL:PNE77493.1}; OS Burkholderia thailandensis. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=57975 {ECO:0000313|EMBL:PNE77493.1, ECO:0000313|Proteomes:UP000235972}; RN [1] {ECO:0000313|Proteomes:UP000235972} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_243 {ECO:0000313|Proteomes:UP000235972}; RA Hoffmann M., Allard M., Evans P., Brown E., Tallon L., Sadzewicz L., RA Sengamalay N., Ott S., Godinez A., Nagaraj S., Vavikolanu K., RA Aluvathingal J., Nadendla S., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx tests."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the conversion of acetoacetate to acetone and CC carbon dioxide. {ECO:0000256|HAMAP-Rule:MF_00597}. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetoacetate + H(+) = acetone + CO2; Xref=Rhea:RHEA:19729, CC ChEBI:CHEBI:13705, ChEBI:CHEBI:15347, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16526; EC=4.1.1.4; Evidence={ECO:0000256|HAMAP- CC Rule:MF_00597}; CC -!- SIMILARITY: Belongs to the ADC family. {ECO:0000256|HAMAP- CC Rule:MF_00597}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PNE77493.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; NBSQ01000001; PNE77493.1; -; Genomic_DNA. DR RefSeq; WP_009894527.1; NZ_WVUL01000026.1. DR GeneID; 45117528; -. DR Proteomes; UP000235972; Unassembled WGS sequence. DR GO; GO:0047602; F:acetoacetate decarboxylase activity; IEA:UniProtKB-UniRule. DR Gene3D; 2.40.400.10; -; 1. DR HAMAP; MF_00597; ADC; 1. DR InterPro; IPR010451; Acetoacetate_decarboxylase. DR InterPro; IPR023653; Acetoacetate_decarboxylase_bac. DR InterPro; IPR023375; ADC_dom_sf. DR Pfam; PF06314; ADC; 1. DR SUPFAM; SSF160104; SSF160104; 1. PE 3: Inferred from homology; KW Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597}; KW Lyase {ECO:0000256|HAMAP-Rule:MF_00597, ECO:0000313|EMBL:PNE77493.1}; KW Schiff base {ECO:0000256|HAMAP-Rule:MF_00597}. FT ACT_SITE 116 FT /note="Schiff-base intermediate with acetoacetate" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00597" SQ SEQUENCE 246 AA; 27436 MW; 027F06947B06D483 CRC64; MKPSQVRSKA FAMPLTSPAF PMGPYRFVNR EFLIITYRTD MDRLREIVPE PLEVKEPLVH YEFIRMPDST GFGDYTESGQ VIPVEYKGQP GGYTLAMYLN DHPPIAGGRE LWGFPKKLAQ PTLATHIDTL LGTLDYGPVR VATGTMGYKH QELDLEEQAK RLAGANFLLK IIPHVDGSAR VCELVRYYLQ DIKMKGAWTG PASLQLAPHA LAPVADLPVL EIVEARHLLA DLTLGLGEVV YDYLAQ //