ID A0A1B4K161_BURTH Unreviewed; 246 AA. AC A0A1B4K161; DT 18-JAN-2017, integrated into UniProtKB/TrEMBL. DT 18-JAN-2017, sequence version 1. DT 13-NOV-2019, entry version 18. DE RecName: Full=Probable acetoacetate decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597}; DE Short=AAD {ECO:0000256|HAMAP-Rule:MF_00597}; DE Short=ADC {ECO:0000256|HAMAP-Rule:MF_00597}; DE EC=4.1.1.4 {ECO:0000256|HAMAP-Rule:MF_00597}; GN Name=adc {ECO:0000256|HAMAP-Rule:MF_00597}; GN ORFNames=A8H35_24180 {ECO:0000313|EMBL:AWY61294.1}, A8H37_03860 GN {ECO:0000313|EMBL:PNE77493.1}, C6946_01660 GN {ECO:0000313|EMBL:TGB35453.1}; OS Burkholderia thailandensis. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Burkholderia; pseudomallei group. OX NCBI_TaxID=57975 {ECO:0000313|EMBL:PNE77493.1, ECO:0000313|Proteomes:UP000235972}; RN [1] {ECO:0000313|EMBL:AWY61294.1, ECO:0000313|Proteomes:UP000280518} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_241 {ECO:0000313|EMBL:AWY61294.1, RC ECO:0000313|Proteomes:UP000280518}; RA Minogue T., Wolcott M., Wasieloski L., Aguilar W., Moore D., RA Tallon L., Sadzewicz L., Sengamalay N., Ott S., Godinez A., RA Nagaraj S., Nadendla S., Geyer C., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx RT tests."; RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:PNE77493.1, ECO:0000313|Proteomes:UP000235972} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_243 {ECO:0000313|EMBL:PNE77493.1, RC ECO:0000313|Proteomes:UP000235972}; RA Hoffmann M., Allard M., Evans P., Brown E., Tallon L., Sadzewicz L., RA Sengamalay N., Ott S., Godinez A., Nagaraj S., Vavikolanu K., RA Aluvathingal J., Nadendla S., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx RT tests."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|EMBL:TGB35453.1, ECO:0000313|Proteomes:UP000298080} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=BtAR2017 {ECO:0000313|EMBL:TGB35453.1, RC ECO:0000313|Proteomes:UP000298080}; RX PubMed=30334705; RA Gee J.E., Elrod M.G., Gulvik C.A., Haselow D.T., Waters C., Liu L., RA Hoffmaster A.R.; RT "Burkholderia thailandensis Isolated from Infected Wound, Arkansas, RT USA."; RL Emerg. Infect. Dis. 24:2091-2094(2018). RN [4] {ECO:0000313|EMBL:TGB35453.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=BtAR2017 {ECO:0000313|EMBL:TGB35453.1}; RA Gulvik C.A.; RL Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Catalyzes the conversion of acetoacetate to acetone and CC carbon dioxide. {ECO:0000256|HAMAP-Rule:MF_00597}. CC -!- CATALYTIC ACTIVITY: CC Reaction=acetoacetate + H(+) = acetone + CO2; CC Xref=Rhea:RHEA:19729, ChEBI:CHEBI:13705, ChEBI:CHEBI:15347, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526; EC=4.1.1.4; CC Evidence={ECO:0000256|HAMAP-Rule:MF_00597}; CC -!- SIMILARITY: Belongs to the ADC family. {ECO:0000256|HAMAP- CC Rule:MF_00597}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP022215; AWY61294.1; -; Genomic_DNA. DR EMBL; NBSQ01000001; PNE77493.1; -; Genomic_DNA. DR EMBL; SRIN01000004; TGB35453.1; -; Genomic_DNA. DR RefSeq; WP_009894527.1; NZ_SRIN01000004.1. DR KEGG; btha:DR62_4906; -. DR KO; K01574; -. DR BioCyc; GCF_001718635:G1F4N-3947-MONOMER; -. DR Proteomes; UP000235972; Unassembled WGS sequence. DR Proteomes; UP000280518; Chromosome 2. DR Proteomes; UP000298080; Unassembled WGS sequence. DR GO; GO:0047602; F:acetoacetate decarboxylase activity; IEA:UniProtKB-UniRule. DR Gene3D; 2.40.400.10; -; 1. DR HAMAP; MF_00597; ADC; 1. DR InterPro; IPR010451; Acetoacetate_decarboxylase. DR InterPro; IPR023653; Acetoacetate_decarboxylase_bac. DR InterPro; IPR023375; ADC_dom_sf. DR Pfam; PF06314; ADC; 1. DR SUPFAM; SSF160104; SSF160104; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000235972, KW ECO:0000313|Proteomes:UP000280518, ECO:0000313|Proteomes:UP000298080}; KW Decarboxylase {ECO:0000256|HAMAP-Rule:MF_00597}; KW Lyase {ECO:0000256|HAMAP-Rule:MF_00597, ECO:0000313|EMBL:PNE77493.1}; KW Schiff base {ECO:0000256|HAMAP-Rule:MF_00597}. FT ACT_SITE 116 116 Schiff-base intermediate with FT acetoacetate. {ECO:0000256|HAMAP-Rule: FT MF_00597}. SQ SEQUENCE 246 AA; 27436 MW; 027F06947B06D483 CRC64; MKPSQVRSKA FAMPLTSPAF PMGPYRFVNR EFLIITYRTD MDRLREIVPE PLEVKEPLVH YEFIRMPDST GFGDYTESGQ VIPVEYKGQP GGYTLAMYLN DHPPIAGGRE LWGFPKKLAQ PTLATHIDTL LGTLDYGPVR VATGTMGYKH QELDLEEQAK RLAGANFLLK IIPHVDGSAR VCELVRYYLQ DIKMKGAWTG PASLQLAPHA LAPVADLPVL EIVEARHLLA DLTLGLGEVV YDYLAQ //