ID   A0A1B2VXX6_URSSP        Unreviewed;        92 AA.
AC   A0A1B2VXX6;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   15-FEB-2017, entry version 4.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|RuleBase:RU004419};
DE            EC=1.6.5.3 {ECO:0000256|RuleBase:RU004419};
DE   Flags: Fragment;
GN   Name=ND4L {ECO:0000313|EMBL:AOD42241.1};
OS   Ursus spelaeus (Cave bear).
OG   Mitochondrion {ECO:0000313|EMBL:AOD42241.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae;
OC   Ursus.
OX   NCBI_TaxID=39097 {ECO:0000313|EMBL:AOD42241.1};
RN   [1] {ECO:0000313|EMBL:AOD42241.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=27506329;
RA   Fortes G.G., Grandal-d'Anglade A., Kolbe B., Fernandes D., Meleg I.N.,
RA   Garcia-Vazquez A., Pinto-Llona A.C., Constantin S., de Torres T.J.,
RA   Ortiz J.E., Frischauf C., Rabeder G., Hofreiter M., Barlow A.;
RT   "Ancient DNA reveals differences in behaviour and sociality between
RT   brown bears and extinct cave bears.";
RL   Mol. Ecol. 0:0-0(2016).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone. {ECO:0000256|RuleBase:RU004419}.
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone + 5 H(+)(In) = NAD(+) +
CC       ubiquinol + 4 H(+)(Out). {ECO:0000256|RuleBase:RU004419}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 4L family.
CC       {ECO:0000256|RuleBase:RU004419}.
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DR   EMBL; KX641313; AOD42241.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K.
DR   PANTHER; PTHR11434; PTHR11434; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU004419,
KW   ECO:0000313|EMBL:AOD42241.1}; NAD {ECO:0000256|RuleBase:RU004419};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004419};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubiquinone {ECO:0000256|RuleBase:RU004419}.
FT   TRANSMEM     20     43       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     55     75       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AOD42241.1}.
SQ   SEQUENCE   92 AA;  10084 MW;  6265FAA760632E8D CRC64;
     NIFLAFIVSL MGLLIYRSHL MSSLLCLEGM VLSLFVMLTV TVLNNHFTLA NMAPIILLVF
     AACEAALGLS LLVMVSNTYG TDYVQNLNLL QC
//