ID A0A1B2VXX6_URSSP Unreviewed; 92 AA. AC A0A1B2VXX6; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 03-MAY-2023, entry version 21. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|ARBA:ARBA00016612, ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004419}; DE Flags: Fragment; GN Name=ND4L {ECO:0000313|EMBL:AOD42241.1}; OS Ursus spelaeus (Cave bear). OG Mitochondrion {ECO:0000313|EMBL:AOD42241.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=39097 {ECO:0000313|EMBL:AOD42241.1}; RN [1] {ECO:0000313|EMBL:AOD42241.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27506329; RA Fortes G.G., Grandal-d'Anglade A., Kolbe B., Fernandes D., Meleg I.N., RA Garcia-Vazquez A., Pinto-Llona A.C., Constantin S., de Torres T.J., RA Ortiz J.E., Frischauf C., Rabeder G., Hofreiter M., Barlow A.; RT "Ancient DNA reveals differences in behaviour and sociality between brown RT bears and extinct cave bears."; RL Mol. Ecol. 0:0-0(2016). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. {ECO:0000256|ARBA:ARBA00024311, CC ECO:0000256|RuleBase:RU004419}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004419}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000256|ARBA:ARBA00024376}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU004419}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|ARBA:ARBA00010519, ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX641313; AOD42241.1; -; Genomic_DNA. DR AlphaFoldDB; A0A1B2VXX6; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.287.3510; -; 1. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434:SF0; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L; 1. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|RuleBase:RU004419, ECO:0000313|EMBL:AOD42241.1}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU004419}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU004419}; Transport {ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 20..43 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 55..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AOD42241.1" SQ SEQUENCE 92 AA; 10084 MW; 6265FAA760632E8D CRC64; NIFLAFIVSL MGLLIYRSHL MSSLLCLEGM VLSLFVMLTV TVLNNHFTLA NMAPIILLVF AACEAALGLS LLVMVSNTYG TDYVQNLNLL QC //