ID A0A1B2VXX6_URSSP Unreviewed; 92 AA. AC A0A1B2VXX6; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 11-DEC-2019, entry version 10. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004419}; DE Flags: Fragment; GN Name=ND4L {ECO:0000313|EMBL:AOD42241.1}; OS Ursus spelaeus (Cave bear). OG Mitochondrion {ECO:0000313|EMBL:AOD42241.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=39097 {ECO:0000313|EMBL:AOD42241.1}; RN [1] {ECO:0000313|EMBL:AOD42241.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27506329; RA Fortes G.G., Grandal-d'Anglade A., Kolbe B., Fernandes D., Meleg I.N., RA Garcia-Vazquez A., Pinto-Llona A.C., Constantin S., de Torres T.J., RA Ortiz J.E., Frischauf C., Rabeder G., Hofreiter M., Barlow A.; RT "Ancient DNA reveals differences in behaviour and sociality between brown RT bears and extinct cave bears."; RL Mol. Ecol. 0:0-0(2016). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|RuleBase:RU004419}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU004419}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU004419}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX641313; AOD42241.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:UniProtKB-UniRule. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434; PTHR11434; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|RuleBase:RU004419, ECO:0000313|EMBL:AOD42241.1}; KW NAD {ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004419}; KW Transport {ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 20..43 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 55..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AOD42241.1" SQ SEQUENCE 92 AA; 10084 MW; 6265FAA760632E8D CRC64; NIFLAFIVSL MGLLIYRSHL MSSLLCLEGM VLSLFVMLTV TVLNNHFTLA NMAPIILLVF AACEAALGLS LLVMVSNTYG TDYVQNLNLL QC //