ID A0A1B1TJQ8_CLABA Unreviewed; 438 AA. AC A0A1B1TJQ8; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 27-MAR-2024, entry version 18. DE RecName: Full=Ammonium transporter Rh type A {ECO:0000256|ARBA:ARBA00041037}; DE AltName: Full=Erythrocyte membrane glycoprotein Rh50 {ECO:0000256|ARBA:ARBA00042473}; DE AltName: Full=Rhesus blood group family type A glycoprotein {ECO:0000256|ARBA:ARBA00042104}; GN Name=rhag {ECO:0000313|EMBL:ANV82514.1}; OS Clarias batrachus (Walking catfish) (Silurus batrachus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Clariidae; Clarias. OX NCBI_TaxID=59899 {ECO:0000313|EMBL:ANV82514.1}; RN [1] {ECO:0000313|EMBL:ANV82514.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Liver {ECO:0000313|EMBL:ANV82514.1}; RA Banerjee B., Koner D., Saha N.; RT "Expression of ornithine-urea cycle related genes under hyper-ammonia RT stress in Clarias batrachus."; RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the CC elimination of ammonia in the gill. {ECO:0000256|ARBA:ARBA00025220}. CC -!- CATALYTIC ACTIVITY: CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526; CC Evidence={ECO:0000256|ARBA:ARBA00035761}; CC -!- CATALYTIC ACTIVITY: CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747, CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00000309}; CC -!- CATALYTIC ACTIVITY: CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391, CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036281}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh CC subfamily. {ECO:0000256|ARBA:ARBA00011036}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KU554718; ANV82514.1; -; mRNA. DR AlphaFoldDB; A0A1B1TJQ8; -. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro. DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1. DR InterPro; IPR029020; Ammonium/urea_transptr. DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom. DR InterPro; IPR002229; RhesusRHD. DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1. DR PANTHER; PTHR11730:SF32; AMMONIUM TRANSPORTER RH TYPE A; 1. DR Pfam; PF00909; Ammonium_transp; 1. DR PRINTS; PR00342; RHESUSRHD. DR SUPFAM; SSF111352; Ammonium transporter; 1. PE 2: Evidence at transcript level; KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 58..81 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 93..112 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 181..199 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 211..231 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 243..265 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 303..323 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 343..360 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 372..393 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 51..408 FT /note="Ammonium transporter AmtB-like" FT /evidence="ECO:0000259|Pfam:PF00909" FT REGION 416..438 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 422..438 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 438 AA; 47127 MW; B4309BB34E2A9923 CRC64; MPAFSTNMRL KFPIVALLLE VVTIVLYAVF VVYDDGNYSG HHGPEKNWNH ANETNPVALY PMFQDVHVMI FIGFGFLMTF LKRYGFSSVG MNLLLAAFGL QWGLLIQNIW HLHDGKIPVS IKSMINADFS TATVLISFGA VLGKTSPVQL LIMTLLEITT FCINEFLVVE KLEASDIGAS MTIHAFGAYF GLAVARMLYR PGLRNGHNNE GSVYHSDLFA MIGTVYLWMF WPSFNSAIAE PGAPQLTAII NTYFSLAACA LAAYATSSLV EEKGKLDMVH IQNATLAGGV AVGTCADMAI APYGAMLIGV FAGVISTIGF KFLTPILASR LGIQDTCGVH NLHGMPGILG GLAGIVAAAL GKKKDISPSY QAAALASSLG FALIGGTITG LILKLPFWGQ PPDQNCFDDS LYWEVPEEEE EAGESLSHTD HSKNKGDA //