ID A0A1B1M0P9_PLADU Unreviewed; 2946 AA. AC A0A1B1M0P9; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 19-JAN-2022, entry version 26. DE SubName: Full=Adenomatous polyposis coli {ECO:0000313|EMBL:ANS60439.1}; OS Platynereis dumerilii (Dumeril's clam worm). OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta; OC Errantia; Phyllodocida; Nereididae; Platynereis. OX NCBI_TaxID=6359 {ECO:0000313|EMBL:ANS60439.1}; RN [1] {ECO:0000313|EMBL:ANS60439.1} RP NUCLEOTIDE SEQUENCE. RA Noorani M.; RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ANS60439.1} RP NUCLEOTIDE SEQUENCE. RA Simon F.; RT "Beta-catenin controls segment polarity in the annelid Platynereis."; RL Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family. CC {ECO:0000256|ARBA:ARBA00009051}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KT266548; ANS60439.1; -; mRNA. DR GO; GO:0071944; C:cell periphery; IEA:UniProt. DR GO; GO:0005737; C:cytoplasm; IEA:UniProt. DR GO; GO:0008013; F:beta-catenin binding; IEA:InterPro. DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:InterPro. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.25.10.10; -; 1. DR InterPro; IPR026818; Apc_fam. DR InterPro; IPR041257; APC_rep. DR InterPro; IPR009223; APC_rpt. DR InterPro; IPR011989; ARM-like. DR InterPro; IPR016024; ARM-type_fold. DR InterPro; IPR000225; Armadillo. DR InterPro; IPR009224; SAMP. DR PANTHER; PTHR12607; PTHR12607; 5. DR Pfam; PF05923; APC_r; 6. DR Pfam; PF18797; APC_rep; 1. DR Pfam; PF00514; Arm; 1. DR Pfam; PF05924; SAMP; 1. DR SMART; SM00185; ARM; 7. DR SUPFAM; SSF48371; SSF48371; 1. DR PROSITE; PS50176; ARM_REPEAT; 2. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}. FT REPEAT 350..378 FT /note="ARM" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259" FT REPEAT 486..514 FT /note="ARM" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259" FT REGION 239..272 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 666..726 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 741..826 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 886..905 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 946..966 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 994..1057 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1062..1081 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1132..1172 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1220..1356 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1467..1494 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1510..1560 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1598..1656 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1685..1746 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1861..1941 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2115..2186 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2246..2856 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2868..2903 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2917..2946 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 252..266 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 669..683 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 748..770 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 779..793 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 800..826 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 948..966 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1008..1057 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1220..1238 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1248..1265 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1324..1343 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1515..1545 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1713..1733 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1894..1920 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2115..2146 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2148..2186 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2246..2266 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2273..2294 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2302..2337 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2412..2449 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2538..2602 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2614..2641 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2677..2700 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2715..2735 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2754..2770 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2785..2799 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 2812..2829 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 2946 AA; 319714 MW; CD882A584B5D088F CRC64; MEKRLQRKQD VLKDMTNVPH FILPLLSRQL GDGEGVVCLD ANNGSPLVTI GTQTLEYQQE EGHEEQEPAN QNLATLYHGA WPTFDKGNAV GNMGPGVAAF PDTASVMSFN SAHTSSTQAN AARTTSNHQL GTKVEMVYSL LSMLGTHDKD DMSRTLLAMS SSQDSCIAMR QSGCLPLLVQ LLHGSDKDSV LGNTRGRKTA RARAAAALHN IVHSHPDDKR GRREARVLRL LEQIRAHCDQ LRDSPDEDED AENQDSNKKA TGHGSADIDH HPGPAIAALM KLSFDEEHRH AICTLGGLQA IAELLQLDHD ANGNTSEQYN ITMRRYACMA LTNLTFGDGT NKALLCSMKT CMKALVAQLQ SSNEDLRQVA ASVLRNLSWR ADLASKKTLR EVGAVVALMK ASMEVSKEST LKSILSALWN LSAHCSENKA DICAVDESLA FLVSTLTYKS PSKTLAIIEN GGGILRNISS HIAIREEYRK VLREHGCLQI LLKHLRSPSL TIVSNACGTL WNLSARCPED QRALWELGAV NMLRNLVHSK HKMISMGSAA ALKNLLAAKP SMMTLDGDKH KQSNMPTLHV RKQRALEAEL DQTLAETCDN VESPSGSPTE QRKHIPVDAS KNFVFGNDNN AYQSGEPDHR RSFVRNQFAR NPSADAAFML EAKMRSPSRP VSRSGSQDSV GSVHSDISHD RVRTHNVLAK SNRLLTERQN MNSDRRMGDR RAGPNSRIVQ VMQEVAIHAG IDGNYMRESH SAENTPPTMR RSQTNPTLRD AANLPPRINN YMKNGQQFSP RHSIAGDTHL AQRLGQQQPT QQQQQQQTQQ SPNEGQIPYQ NITQCMESLH LDDDSSQEQP INYSLKYADG PNQAKQANNV GNFMHELMYN GQSQVPAQNA QSMKSPPHKA NSQYSEFSEQ DNDAMDQPTN YSIRFAEQVD DGHFSDQPIN YSTRFQESGA NEDEEADNTV IHQEQDEMNL DTIRTFCTEG TPYLSTATSM EDLTGIGKED KPKTPQTKAN PESKQYPSHF TESHSSKSTE HQTSSTVVRG KQTESAANIQ NNNVSRVVDT VPQPSLYSYN DNVTASPGSE KPMQYCTEGT PTCFSRVSSL SSLHSTDAHD HPDNNQNRGD LTLQSIDENH SLETTNRQTG GTPMRPDSHN RSLNATNGSI GSGTNTPSHH KSVTFDENNQ VQETPLMFSR CSSLGSLSSF DAHSVHSSVV SDYSRRASEV VSPSELPDSP SDSMPGSPSR KSPVKFDSKL NDSQSTNITQ IRKPVVQQQP PPPANISAAG EESNVQIVRP IPTKTLFADS PKQFGDEGTP DFSCATSLSG LDLDEPDICR DSELERIPLG PEEGEEEAPS SGEPSQLEFT VIEKTENAAE SDNDSVSEGD EDILNEYMMM AMPKRKAKKS SSQSQVAAAD VPRSPYIKVP SGYVNLDIED PMDTIKQYGT EDTPLNYSRD DALSNLSFNS STGELVNLGG LGERESPTND DDDKSDISSI ADDGEDCEDL LSEAIAAAMP KKVAKASKSD NRTAKGQMER PKEGALVKEK HQQQNMRQHS QQQVYPQRGS LSVAARAVSH SVPPQSDCIR TYCEEGTPIN FSRATSLSEL SQLDPDGASQ DHSVGSELDE SDQFDEIPTA YFDGDTSLPV EIMDSPTSFG MEGTPLSFSR NDSLSSLSCD EDAELENAKQ HLKGAKLPLH SKGSPKSLLT PKQRLLGRLK SPGSGSKNRS PGSRAQRNLA FGKPQPQSPL AMSPPRSEYD QIQMFAVEGT PHCFSRNSSL SSLNSTDNDI SANVSDIKGD EDAQQACSSG DTSAEQEHIE GQLPPDSFYV EDTPANFSRN SSLSSLSVES LGFEPSEAAL LEECINAAMP KTKSAKKKVS KIPRNCPTST PKDKFVKPRT PPSGNQPKVK TPSPSREGSP KNVQSSQHGN EVERTRVEEQ NTSEHPQLTI ENVVWRHRSP SQELEGSPKL LKDASNQEKV LGALMMESED KNSEEKDDSQ VKGLVFDFDN KLYISESDLD NKNDVEDYNN KLVDMELANS DMIASAIFRE ASEIAEGFAE AAQLEDESCS ESDYPIVAKE EIEATKENPV VEGDEQLGCF PIDCSFHDIT KETFPDMGLS LGSSMMSSVG DDNQVTVRSK SSTGASVRNV SNETDLSLDE GVGHDDSNDT AIEDDDSKRF SDVTEGSDTN SHEITLEEEQ ALEENAELLI RELSNVHLSQ LSSSVNSEMF IENETISLVS NDTDTCSEVS VSLSCSSKAM SEKTNEDSNA SSSAASRPRI LKPGERSSLE VKAKEEEVKA VRGKRKPLTS RVNSGRPPSV SSPMKNDTKS KKTTPPTKPN TVKSKPPVGN TKVIPKTPSK VTPAAKSNVT PAAKAAPKMK PLAGKPTAGV KPTPKASAVV APMTKNTNAT RAAARKPSPA RSGTASPRNQ SPADKMRNKT TTKEPSSLAS TNVKKPQSKV TSALIKGKAK NSGKVNNNEA DRPKPPIKQG TFTKDSPTQN APEIEGDDNE DIKDDSPSSN RSSAELKYSN DTQEKAPGEK ISPRSSKADA AGPSSTPPAV ANLKQNGSQK AVAGKSNSTG NLTKTTKSVT KTASGSNLTK TGSNTSLTKG SGTFKVPKAP LKKGDSMSNQ SLKKDSSKPG TSVTTPKKGT GNDKTGGRAT VPVASKIASL WRKGDSKTAS PSKAGPEKKT PLKKEKEKTP AAKSETKPKF LRRSLASSQP SKGAKEDGKQ SKTPNKKDDK GMQRSSTYDK LPVNEGEAES AEKAETSSGG SPAKNNVWRR TYTIENEEEV LQAVTTDDCE TSNSPGVWMR RDNDRTPVKS QIPAPVRSSP EQSGDGRGNK PSPPSAFPNK SGLGISPPGA KPTVTSPNAA IVAPFNYVPT QSLNNKPVSS ANDENDLKGM KPNNGTDSPT RPMTKTEMLI ARRRQSYLNS VNKSGEEQKT SEEDESKRTA CLVTTV //