ID A0A1B1JH81_TRYCR Unreviewed; 516 AA. AC A0A1B1JH81; DT 02-NOV-2016, integrated into UniProtKB/TrEMBL. DT 02-NOV-2016, sequence version 1. DT 25-OCT-2017, entry version 8. DE RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283}; DE EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283}; OS Trypanosoma cruzi. OC Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Trypanosoma; OC Schizotrypanum. OX NCBI_TaxID=5693 {ECO:0000313|EMBL:ANS13799.1}; RN [1] {ECO:0000313|EMBL:ANS13799.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Dm28 {ECO:0000313|EMBL:ANS13799.1}; RA Picchi G., Zulkievicz V., Alcantara M., Zanchin N., Pierce R., RA Goldenberg S.; RT "a-Paraddise: Anti-Parasitic Drug Discovery in Epigenetics."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of CC a histone to yield a deacetylated histone. CC {ECO:0000256|SAAS:SAAS00894227}. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX359371; ANS13799.1; -; Genomic_DNA. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC. DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW. DR GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW. DR Gene3D; 3.40.800.20; -; 1. DR InterPro; IPR000286; His_deacetylse. DR InterPro; IPR023801; His_deacetylse_dom. DR InterPro; IPR037138; His_deacetylse_dom_sf. DR InterPro; IPR023696; Ureohydrolase_domain. DR PANTHER; PTHR10625; PTHR10625; 1. DR Pfam; PF00850; Hist_deacetyl; 1. DR PRINTS; PR01270; HDASUPER. DR SUPFAM; SSF52768; SSF52768; 2. PE 4: Predicted; KW Chromatin regulator {ECO:0000256|SAAS:SAAS00894233}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Hydrolase {ECO:0000256|SAAS:SAAS00870288}; KW Nucleus {ECO:0000256|SAAS:SAAS00894277}; KW Transcription {ECO:0000256|SAAS:SAAS00894309}; KW Transcription regulation {ECO:0000256|SAAS:SAAS00894290}. FT DOMAIN 73 385 Hist_deacetyl. {ECO:0000259|Pfam: FT PF00850}. FT COILED 459 515 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 516 AA; 56358 MW; 16F060C779D5161A CRC64; MVFTDAVAGK TSLPPPVAII VGHNIDASAM PLTYERNRFV IDMLQHYACP VFSHKKSGDA MNTVSSDVFE WVLEPLPVVG VEDMTAFHDR AYLNYLSIRE ALSEVDERAS TVKRSRAEGI QPPVSRRSSA QTQPPLRVLP DLVPIPADEE YGLVNENMPF VGMWRTIQAT VSGTLLAARL LAQPGRFAAI HWFGGRHHAK KSTAGGFCFA NDVVLGVLEL KKLLSSDKNG ILVVDVDAHH GDGTQSAFLH DNSVLTLSMH AHGVGIFPGT GGIEEIGAGL GRGFTMNVPL PEGATDILAV TLMYRSIHFA FKKLGEGLAA IVIVCGSDAL SGDPLGALNL TVGGMQSIIR LLLKEAARRS LKVLLLGAGG YVDTSCARLA GVVTKDVLSC AAAMRLGKTE YFGDSANLGD NLGVAVPEGC EYFTRYGPSF LMHGLPPARV SKLYRLPYGS PLFMRMQRAA TKEALRRRLN QEQDEEEDAE DDEEEEEEEE EEEEEEEEEE EEEEEEEEEE EEEEEP //