ID   A0A1B0PE62_9SALA        Unreviewed;       529 AA.
AC   A0A1B0PE62;
DT   02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT   02-NOV-2016, sequence version 1.
DT   05-JUN-2019, entry version 8.
DE   RecName: Full=Catalase {ECO:0000256|RuleBase:RU000498};
DE            EC=1.11.1.6 {ECO:0000256|RuleBase:RU000498};
OS   Cynops orientalis (oriental fire-bellied newt).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Caudata; Salamandroidea; Salamandridae;
OC   Pleurodelinae; Cynops.
OX   NCBI_TaxID=137245 {ECO:0000313|EMBL:AIR07783.1};
RN   [1] {ECO:0000313|EMBL:AIR07783.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ruan S.-L., Sun X.-S., Hu J.-R., Yang W.-X.;
RT   "Cd-induced metallothionein and catalase gene expression, along with
RT   morphological damages in the testis of Chinese fire-bellied newt.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Occurs in almost all aerobically respiring organisms and
CC       serves to protect cells from the toxic effects of hydrogen
CC       peroxide. {ECO:0000256|RuleBase:RU004142}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240;
CC         EC=1.11.1.6; Evidence={ECO:0000256|RuleBase:RU000498};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000256|PIRSR:PIRSR038928-2};
CC   -!- SIMILARITY: Belongs to the catalase family.
CC       {ECO:0000256|RuleBase:RU000498}.
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DR   EMBL; KF751390; AIR07783.1; -; mRNA.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd08156; catalase_clade_3; 1.
DR   Gene3D; 2.40.180.10; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR040333; Catalase_3.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024711; Catalase_clade1/3.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR037060; Catalase_core_sf.
DR   InterPro; IPR002226; Catalase_haem_BS.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR020835; Catalase_sf.
DR   PANTHER; PTHR11465; PTHR11465; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00437; CATALASE_1; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   2: Evidence at transcript level;
KW   Heme {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Hydrogen peroxide {ECO:0000256|RuleBase:RU000498};
KW   Iron {ECO:0000256|PIRSR:PIRSR038928-2, ECO:0000256|RuleBase:RU000498};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR038928-2,
KW   ECO:0000256|RuleBase:RU000498};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000498};
KW   Peroxidase {ECO:0000256|RuleBase:RU000498}.
FT   DOMAIN       28    413       Catalase. {ECO:0000259|SMART:SM01060}.
FT   REGION        1     29       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1B0PE62}.
FT   ACT_SITE     75     75       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   ACT_SITE    148    148       {ECO:0000256|PIRSR:PIRSR038928-1}.
FT   METAL       358    358       Iron (heme axial ligand).
FT                                {ECO:0000256|PIRSR:PIRSR038928-2}.
SQ   SEQUENCE   529 AA;  59968 MW;  B44191A4406EEA06 CRC64;
     MAESRDKAAD QMKSWQESRG KQTPDWLTTG AGIPVSDKLN VLTVGPRGPL LVQDVAFTDE
     MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITNYSKAKVF EHIGKRTPIA VRFSTVAGES
     GSADTVRDPR GFAVKLYTEE GNWDLTGNNT PIFFIRDAML FPSFIHSQKR NPQTHMKDPD
     MVWDFWALRP ESLHQVSFLF SDRGIPNGHR HMNGYGSHTF KLVNAKGEAV YCKFHYKTDQ
     GIKNLSVEEA EKLAATDPDY GIHDLYEAIA NGNYPSWTFY IQVMTFEQAG KFQFNPFDLT
     KVWSHKHYPL IPVGKLVLNR NPINYFAEVE QLAFDPSNMP PGIEPSPDEM LQGRLFSYPD
     THRHRLGANY LQIPVNCPYK TRVANYQRDG PMCMFDNQGG APNYYPNSFS APENQPRVME
     HCFKVSADVA RYNSADDDNV TQVRAFYTQV LNEGERQRLC ENIAGHLKGA QLFIQKRAVK
     NFSDVHPDYG SRIQALLDKH NAEAIGKKNL VRTFQPHASH LSASEKSNL
//