ID A0A1B0GV43_HUMAN Unreviewed; 423 AA. AC A0A1B0GV43; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 22-FEB-2023, entry version 30. DE SubName: Full=Cholinergic receptor nicotinic alpha 7 subunit {ECO:0000313|Ensembl:ENSP00000490365.1}; GN Name=CHRNA7 {ECO:0000313|Ensembl:ENSP00000490365.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000490365.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000490365.1, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16572171; DOI=10.1038/nature04601; RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S., RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S., RA Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., RA Birren B.W., Hood L., Lander E.S., Nusbaum C.; RT "Analysis of the DNA sequence and duplication history of human chromosome RT 15."; RL Nature 440:671-675(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000490365.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (OCT-2022) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. Postsynaptic cell membrane CC {ECO:0000256|ARBA:ARBA00034104}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00034104}. Synaptic cell membrane CC {ECO:0000256|ARBA:ARBA00034099}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00034099}. CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family. CC {ECO:0000256|RuleBase:RU000687}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; ABBA01038340; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC058803; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC068448; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC079969; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456018; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF456023; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF573652; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; A0A1B0GV43; -. DR SMR; A0A1B0GV43; -. DR PeptideAtlas; A0A1B0GV43; -. DR Antibodypedia; 9478; 318 antibodies from 33 providers. DR Ensembl; ENST00000637183.1; ENSP00000490365.1; ENSG00000175344.19. DR HGNC; HGNC:1960; CHRNA7. DR VEuPathDB; HostDB:ENSG00000175344; -. DR GeneTree; ENSGT00940000154617; -. DR OMA; WDLMGIP; -. DR ChiTaRS; CHRNA7; human. DR Proteomes; UP000005640; Chromosome 15. DR Bgee; ENSG00000175344; Expressed in adrenal tissue and 122 other tissues. DR ExpressionAtlas; A0A1B0GV43; baseline and differential. DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022848; F:acetylcholine-gated cation-selective channel activity; IEA:InterPro. DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro. DR CDD; cd19051; LGIC_TM_cation; 1. DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1. DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2. DR InterPro; IPR006202; Neur_chan_lig-bd. DR InterPro; IPR036734; Neur_chan_lig-bd_sf. DR InterPro; IPR006201; Neur_channel. DR InterPro; IPR036719; Neuro-gated_channel_TM_sf. DR InterPro; IPR038050; Neuro_actylchol_rec. DR InterPro; IPR006029; Neurotrans-gated_channel_TM. DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS. DR InterPro; IPR002394; Nicotinic_acetylcholine_rcpt. DR PANTHER; PTHR18945:SF907; NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7; 1. DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1. DR Pfam; PF02931; Neur_chan_LBD; 1. DR Pfam; PF02932; Neur_chan_memb; 1. DR PRINTS; PR00254; NICOTINICR. DR PRINTS; PR00252; NRIONCHANNEL. DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1. DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1. DR TIGRFAMs; TIGR00860; LIC; 1. DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065, KW ECO:0000256|RuleBase:RU000687}; KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687}; KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257}; KW Receptor {ECO:0000256|ARBA:ARBA00023170}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Synapse {ECO:0000256|ARBA:ARBA00023018}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000687}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU000687}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}. FT TRANSMEM 152..177 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT TRANSMEM 183..201 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT TRANSMEM 213..236 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT TRANSMEM 391..411 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU000687" FT DOMAIN 1..151 FT /note="Neurotransmitter-gated ion-channel ligand-binding" FT /evidence="ECO:0000259|Pfam:PF02931" FT DOMAIN 158..408 FT /note="Neurotransmitter-gated ion-channel transmembrane" FT /evidence="ECO:0000259|Pfam:PF02932" SQ SEQUENCE 423 AA; 47434 MW; 38D69334AE8BAF63 CRC64; MSWTDHYLQW NVSEYPGVKT VRFPDGQIWK PDILLYNSAD ERFDATFHTN VLVNSSGHCQ YLPPGIFKSS CYIDVRWFPF DVQHCKLKFG SWSYGGWSLD LQMQEADISG YIPNGEWDLV GIPGKRSERF YECCKEPYPD VTFTVTMRRR TLYYGLNLLI PCVLISALAL LVFLLPADSG EKISLGITVL LSLTVFMLLV AEIMPATSDS VPLIAQYFAS TMIIVGLSVV VTVIVLQYHH HDPDGGKMPK WTRVILLNWC AWFLRMKRPG EDKVRPACQH KQRRCSLASV EMSAVAPPPA SNGNLLYIGF RGLDGVHCVP TPDSGVVCGR MACSPTHDEH LLHGGQPPEG DPDLAKILEE VRYIANRFRC QDESEAVCSE WKFAACVVDR LCLMAFSVFT IICTIGILMS APNFVEAVSK DFA //