ID A0A1B0GTN0_HUMAN Unreviewed; 2170 AA. AC A0A1B0GTN0; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 24-JUL-2024, entry version 45. DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808}; GN Name=CACNA1D {ECO:0000313|Ensembl:ENSP00000489769.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489769.1, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X., RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000489769.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (APR-2024) to UniProtKB. CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry CC of calcium ions into excitable cells and are also involved in a variety CC of calcium-dependent processes, including muscle contraction, hormone CC or neurotransmitter release, gene expression, cell motility, cell CC division and cell death. {ECO:0000256|RuleBase:RU003808}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141, CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}. CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC CC 1.A.1.11) family. CACNA1D subfamily. {ECO:0000256|ARBA:ARBA00010354}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC005905; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC012467; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092035; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC112218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132810; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR SMR; A0A1B0GTN0; -. DR MassIVE; A0A1B0GTN0; -. DR PeptideAtlas; A0A1B0GTN0; -. DR Antibodypedia; 4062; 346 antibodies from 32 providers. DR Ensembl; ENST00000637424.1; ENSP00000489769.1; ENSG00000157388.20. DR HGNC; HGNC:1391; CACNA1D. DR VEuPathDB; HostDB:ENSG00000157388; -. DR GeneTree; ENSGT00940000154839; -. DR ChiTaRS; CACNA1D; human. DR Proteomes; UP000005640; Chromosome 3. DR Bgee; ENSG00000157388; Expressed in buccal mucosa cell and 149 other cell types or tissues. DR ExpressionAtlas; A0A1B0GTN0; baseline and differential. DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro. DR Gene3D; 1.10.287.70; -; 4. DR Gene3D; 6.10.250.2180; -; 1. DR Gene3D; 6.10.250.2500; -; 1. DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4. DR InterPro; IPR031688; CAC1F_C. DR InterPro; IPR031649; GPHH_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR005452; LVDCC_a1dsu. DR InterPro; IPR014873; VDCC_a1su_IQ. DR InterPro; IPR050599; VDCC_alpha-1_subunit. DR InterPro; IPR005446; VDCC_L_a1su. DR InterPro; IPR002077; VDCCAlpha1. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1. DR PANTHER; PTHR45628:SF11; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1D; 1. DR Pfam; PF08763; Ca_chan_IQ; 1. DR Pfam; PF16885; CAC1F_C; 1. DR Pfam; PF16905; GPHH; 1. DR Pfam; PF00520; Ion_trans; 4. DR PRINTS; PR00167; CACHANNEL. DR PRINTS; PR01630; LVDCCALPHA1. DR PRINTS; PR01636; LVDCCALPHA1D. DR SMART; SM01062; Ca_chan_IQ; 1. DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673, KW ECO:0000256|RuleBase:RU003808}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568, KW ECO:0000256|RuleBase:RU003808}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3}; KW Ion channel {ECO:0000256|ARBA:ARBA00023303}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRSR:PIRSR602077-1}; KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A1B0GTN0, KW ECO:0007829|ProteomicsDB:A0A1B0GTN0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}; KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882, KW ECO:0000256|RuleBase:RU003808}. FT TRANSMEM 154..171 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 191..211 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 223..242 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 295..318 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 374..395 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 407..429 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 547..565 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 585..608 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 677..696 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 749..776 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 911..929 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 949..969 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 981..1007 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1027..1057 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1154..1179 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1233..1251 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1263..1283 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1358..1376 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1450..1473 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1607..1641 FT /note="Voltage-dependent calcium channel alpha-1 subunit FT IQ" FT /evidence="ECO:0000259|SMART:SM01062" FT REGION 88..124 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 473..506 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 790..874 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1668..1687 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1693..1813 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1881..1928 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2117..2161 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 486..506 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 790..812 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 827..846 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 847..862 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1706..1721 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1746..1775 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1791..1813 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1884..1917 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT BINDING 388 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT BINDING 729 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT BINDING 1125 FT /ligand="Ca(2+)" FT /ligand_id="ChEBI:CHEBI:29108" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1" FT CARBOHYD 353 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3" SQ SEQUENCE 2170 AA; 246198 MW; 708F35D4ECDBE75A CRC64; MEMNLPTFSS DLIFIKSTMY QEIDARYKGK VISEAETKGY FSLAFGEANY ARGTRLPLSG EGPTSQPNSS KQTVLSWQAA IDAARQAKAA QTMSTSAPPP VGSLSQRKRQ QYAKSKKQGN SSNSRPARAL FCLSLNNPIR RACISIVEWK PFDIFILLAI FANCVALAIY IPFPEDDSNS TNHNLEKVEY AFLIIFTVET FLKIIAYGLL LHPNAYVRNG WNLLDFVIVI VGLFSVILEQ LTKETEGGNH SSGKSGGFDV KALRAFRVLR PLRLVSGVPS LQVVLNSIIK AMVPLLHIAL LVLFVIIIYA IIGLELFIGK MHKTCFFADS DIVAEEDPAP CAFSGNGRQC TANGTECRSG WVGPNGGITN FDNFAFAMLT VFQCITMEGW TDVLYWVNDA IGWEWPWVYF VSLIILGSFF VLNLVLGVLS GEFSKEREKA KARGDFQKLR EKQQLEEDLK GYLDWITQAE DIDPENEEEG GEEGKRNTSM PTSETESVNT ENVSGEGENR GCCGSLCQAI SKSKLSRRWR RWNRFNRRRC RAAVKSVTFY WLVIVLVFLN TLTISSEHYN QPDWLTQIQD IANKVLLALF TCEMLVKMYS LGLQAYFVSL FNRFDCFVVC GGITETILVE LEIMSPLGIS VFRCVRLLRI FKVTRHWTSL SNLVASLLNS MKSIASLLLL LFLFIIIFSL LGMQLFGGKF NFDETQTKRS TFDNFPQALL TVFQILTGED WNAVMYDGIM AYGGPSSSGM IVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLNTAQK EEAEEKERKK IARKESLENK KNNKPEVNQI ANSDNKVTID DYREEDEDKD PYPPCDVPVG EEEEEEEEDE PEVPAGPRPR RISELNMKEK IAPIPEGSAF FILSKTNPIR VGCHKLINHH IFTNLILVFI MLSSAALAAE DPIRSHSFRN TILGYFDYAF TAIFTVEILL KMTTFGAFLH KGAFCRNYFN LLDMLVVGVS LVSFGIQSSA ISVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIMIVTTLLQ FMFACIGVQL FKGKFYRCTD EAKSNPEECR GLFILYKDGD VDSPVVRERI WQNSDFNFDN VLSAMMALFT VSTFEGWPAL LYKAIDSNGE NIGPIYNHRV EISIFFIIYI IIVAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV EYALKARPLR RYIPKNPYQY KFWYVVNSSP FEYMMFVLIM LNTLCLAMQH YEQSKMFNDA MDILNMVFTG VFTVEMVLKV IAFKPKGYFS DAWNTFDSLI VIGSIIDVAL SEADNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSNFAI VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ AGLRTLHDIG PEIRRAISCD LQDDEPEETK REEEDDVFKR NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSIPPA SDTEKPLFPP AGNSVCHNHH NHNSIGKQVP TSTNANLNNA NMSKAAHGKR PSIGNLEHVS ENGHHSSHKH DREPQRRSSV KRTRYYETYI RSDSGDEQLP TICREDPEIH GYFRDPHCLG EQEYFSSEEC YEDDSSPTWS RQNYGYYSRY PGRNIDSERP RGYHHPQGFL EDDDSPVCYD SRRSPRRRLL PPTPASHRRS SFNFECLRRQ SSQEEVPSSP IFPHRTALPL HLMQQQIMAV AGLDSSKAQK YSPSHSTRSW ATPPATPPYR DWTPCYTPLI QVEQSEALDQ VNGSLPSLHR SSWYTDEPDI SYRTFTPASL TVPSSFRNKN SDKQRSADSL VEAVLISEGL GRYARDPKFV SATKHEIADA CDLTIDEMES AASTLLNGNV RPRANGDVGP LSHRQDYELQ DFGPGYSDEE PDPGRDEEDL ADEMICITTL //