ID A0A1B0GTN0_HUMAN Unreviewed; 2170 AA. AC A0A1B0GTN0; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 23-MAY-2018, entry version 15. DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808}; GN Name=CACNA1D {ECO:0000313|Ensembl:ENSP00000489769}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000489769, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000489769, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16641997; DOI=10.1038/nature04728; RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., RA Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., RA Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., RA Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., RA Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., RA Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S., RA Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., RA Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., RA Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., RA Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., RA Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., RA Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., RA Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., RA Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A., RA Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., RA Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., RA Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., RA Gibbs R.A.; RT "The DNA sequence, annotation and analysis of human chromosome 3."; RL Nature 440:1194-1198(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000489769} RP IDENTIFICATION. RG Ensembl; RL Submitted (JUL-2016) to UniProtKB. CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the CC entry of calcium ions into excitable cells and are also involved CC in a variety of calcium-dependent processes, including muscle CC contraction, hormone or neurotransmitter release, gene expression, CC cell motility, cell division and cell death. The isoform alpha-1C CC gives rise to L-type calcium currents. Long-lasting (L-type) CC calcium channels belong to the 'high-voltage activated' (HVA) CC group. They are blocked by dihydropyridines (DHP), CC phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA CC (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- CC GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). CC Calcium channels containing the alpha-1C subunit play an important CC role in excitation-contraction coupling in the heart. Binding of CC calmodulin or CABP1 at the same regulatory sites results in CC opposite effects on the channel function. CC {ECO:0000256|RuleBase:RU003808}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}. CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit CC (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC005905; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC012467; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC024149; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC092035; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC112218; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC132810; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR Ensembl; ENST00000637424; ENSP00000489769; ENSG00000157388. DR HGNC; HGNC:1391; CACNA1D. DR OpenTargets; ENSG00000157388; -. DR GeneTree; ENSGT00830000128247; -. DR ChiTaRS; CACNA1D; human. DR Proteomes; UP000005640; Chromosome 3. DR ExpressionAtlas; A0A1B0GTN0; baseline and differential. DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro. DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro. DR GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW. DR Gene3D; 1.20.120.350; -; 4. DR InterPro; IPR031688; CAC1F_C. DR InterPro; IPR031649; GPHH_dom. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR005452; LVDCC_a1dsu. DR InterPro; IPR014873; VDCC_a1su_IQ. DR InterPro; IPR005446; VDCC_L_a1su. DR InterPro; IPR002077; VDCCAlpha1. DR InterPro; IPR027359; Volt_channel_dom_sf. DR PANTHER; PTHR10037:SF139; PTHR10037:SF139; 1. DR Pfam; PF08763; Ca_chan_IQ; 1. DR Pfam; PF16885; CAC1F_C; 1. DR Pfam; PF16905; GPHH; 1. DR Pfam; PF00520; Ion_trans; 4. DR PRINTS; PR00167; CACHANNEL. DR PRINTS; PR01630; LVDCCALPHA1. DR PRINTS; PR01636; LVDCCALPHA1D. DR SMART; SM01062; Ca_chan_IQ; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|RuleBase:RU003808}; KW Calcium channel {ECO:0000256|RuleBase:RU003808}; KW Calcium transport {ECO:0000256|RuleBase:RU003808}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Ion channel {ECO:0000256|RuleBase:RU003808}; KW Ion transport {ECO:0000256|RuleBase:RU003808}; KW Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Transmembrane {ECO:0000256|SAAS:SAAS00084820, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00084701, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808}; KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}. FT TRANSMEM 154 171 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 191 211 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 223 242 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 295 318 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 374 395 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 407 429 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 547 565 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 585 608 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 677 696 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 749 776 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 911 929 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 949 969 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 981 1007 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1027 1057 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1154 1179 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1233 1251 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1263 1283 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1358 1376 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 1450 1473 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1607 1641 Ca_chan_IQ. {ECO:0000259|SMART:SM01062}. FT COILED 779 810 {ECO:0000256|SAM:Coils}. FT COILED 1568 1588 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 2170 AA; 246198 MW; 708F35D4ECDBE75A CRC64; MEMNLPTFSS DLIFIKSTMY QEIDARYKGK VISEAETKGY FSLAFGEANY ARGTRLPLSG EGPTSQPNSS KQTVLSWQAA IDAARQAKAA QTMSTSAPPP VGSLSQRKRQ QYAKSKKQGN SSNSRPARAL FCLSLNNPIR RACISIVEWK PFDIFILLAI FANCVALAIY IPFPEDDSNS TNHNLEKVEY AFLIIFTVET FLKIIAYGLL LHPNAYVRNG WNLLDFVIVI VGLFSVILEQ LTKETEGGNH SSGKSGGFDV KALRAFRVLR PLRLVSGVPS LQVVLNSIIK AMVPLLHIAL LVLFVIIIYA IIGLELFIGK MHKTCFFADS DIVAEEDPAP CAFSGNGRQC TANGTECRSG WVGPNGGITN FDNFAFAMLT VFQCITMEGW TDVLYWVNDA IGWEWPWVYF VSLIILGSFF VLNLVLGVLS GEFSKEREKA KARGDFQKLR EKQQLEEDLK GYLDWITQAE DIDPENEEEG GEEGKRNTSM PTSETESVNT ENVSGEGENR GCCGSLCQAI SKSKLSRRWR RWNRFNRRRC RAAVKSVTFY WLVIVLVFLN TLTISSEHYN QPDWLTQIQD IANKVLLALF TCEMLVKMYS LGLQAYFVSL FNRFDCFVVC GGITETILVE LEIMSPLGIS VFRCVRLLRI FKVTRHWTSL SNLVASLLNS MKSIASLLLL LFLFIIIFSL LGMQLFGGKF NFDETQTKRS TFDNFPQALL TVFQILTGED WNAVMYDGIM AYGGPSSSGM IVCIYFIILF ICGNYILLNV FLAIAVDNLA DAESLNTAQK EEAEEKERKK IARKESLENK KNNKPEVNQI ANSDNKVTID DYREEDEDKD PYPPCDVPVG EEEEEEEEDE PEVPAGPRPR RISELNMKEK IAPIPEGSAF FILSKTNPIR VGCHKLINHH IFTNLILVFI MLSSAALAAE DPIRSHSFRN TILGYFDYAF TAIFTVEILL KMTTFGAFLH KGAFCRNYFN LLDMLVVGVS LVSFGIQSSA ISVVKILRVL RVLRPLRAIN RAKGLKHVVQ CVFVAIRTIG NIMIVTTLLQ FMFACIGVQL FKGKFYRCTD EAKSNPEECR GLFILYKDGD VDSPVVRERI WQNSDFNFDN VLSAMMALFT VSTFEGWPAL LYKAIDSNGE NIGPIYNHRV EISIFFIIYI IIVAFFMMNI FVGFVIVTFQ EQGEKEYKNC ELDKNQRQCV EYALKARPLR RYIPKNPYQY KFWYVVNSSP FEYMMFVLIM LNTLCLAMQH YEQSKMFNDA MDILNMVFTG VFTVEMVLKV IAFKPKGYFS DAWNTFDSLI VIGSIIDVAL SEADNSEESN RISITFFRLF RVMRLVKLLS RGEGIRTLLW TFIKSFQALP YVALLIAMLF FIYAVIGMQM FGKVAMRDNN QINRNNNFQT FPQAVLLLFR CATGEAWQEI MLACLPGKLC DPESDYNPGE EYTCGSNFAI VYFISFYMLC AFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFKRIWSE YDPEAKGRIK HLDVVTLLRR IQPPLGFGKL CPHRVACKRL VAMNMPLNSD GTVMFNATLF ALVRTALKIK TEGNLEQANE ELRAVIKKIW KKTSMKLLDQ VVPPAGDDEV TVGKFYATFL IQDYFRKFKK RKEQGLVGKY PAKNTTIALQ AGLRTLHDIG PEIRRAISCD LQDDEPEETK REEEDDVFKR NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSIPPA SDTEKPLFPP AGNSVCHNHH NHNSIGKQVP TSTNANLNNA NMSKAAHGKR PSIGNLEHVS ENGHHSSHKH DREPQRRSSV KRTRYYETYI RSDSGDEQLP TICREDPEIH GYFRDPHCLG EQEYFSSEEC YEDDSSPTWS RQNYGYYSRY PGRNIDSERP RGYHHPQGFL EDDDSPVCYD SRRSPRRRLL PPTPASHRRS SFNFECLRRQ SSQEEVPSSP IFPHRTALPL HLMQQQIMAV AGLDSSKAQK YSPSHSTRSW ATPPATPPYR DWTPCYTPLI QVEQSEALDQ VNGSLPSLHR SSWYTDEPDI SYRTFTPASL TVPSSFRNKN SDKQRSADSL VEAVLISEGL GRYARDPKFV SATKHEIADA CDLTIDEMES AASTLLNGNV RPRANGDVGP LSHRQDYELQ DFGPGYSDEE PDPGRDEEDL ADEMICITTL //