ID A0A1A9H0F7_HELPX Unreviewed; 156 AA. AC A0A1A9H0F7; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 02-OCT-2024, entry version 42. DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00017562, ECO:0000256|RuleBase:RU364072}; GN Name=accB {ECO:0000313|EMBL:AUV77571.1}; GN ORFNames=B0X45_00045 {ECO:0000313|EMBL:OOQ12599.1}, C2840_01920 GN {ECO:0000313|EMBL:AUV77571.1}, C2842_01920 GN {ECO:0000313|EMBL:AUV79080.1}, SE88_01905 GN {ECO:0000313|EMBL:AJF10208.1}; OS Helicobacter pylori (Campylobacter pylori). OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=210 {ECO:0000313|EMBL:OOQ12599.1, ECO:0000313|Proteomes:UP000317384}; RN [1] {ECO:0000313|EMBL:AJF10208.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=26695-1MET {ECO:0000313|EMBL:AJF10208.1}; RA Binh T., Suzuki R., Kwon D.H., Yamaoka Y.; RL Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AJF10208.1, ECO:0000313|Proteomes:UP000031529} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-1MET {ECO:0000313|EMBL:AJF10208.1, RC ECO:0000313|Proteomes:UP000031529}; RX PubMed=25767223; RA Binh T.T., Suzuki R., Kwon D.H., Yamaoka Y.; RT "Complete Genome Sequence of a Metronidazole-Resistant Helicobacter pylori RT Strain."; RL Genome Announc. 3:0-0(2015). RN [3] {ECO:0000313|EMBL:OOQ12599.1, ECO:0000313|Proteomes:UP000317384} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CC26100 {ECO:0000313|EMBL:OOQ12599.1, RC ECO:0000313|Proteomes:UP000317384}; RX PubMed=28293542; DOI=.3389/fcimb.2017.00050; RA Munoz-Ramirez Z.Y., Mendez-Tenorio A., Kato I., Bravo M.M., Rizzato C., RA Thorell K., Torres R.C., Aviles-Jimenez F., Camorlinga M., Canzian F., RA Torres J.; RT "Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori RT Strains from Latin America Have Followed a Unique Evolution Pathway."; RL Front. Cell. Infect. Microbiol. 7:50-50(2017). RN [4] {ECO:0000313|Proteomes:UP000236564, ECO:0000313|Proteomes:UP000236568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}, and 26695-dRdM2 RC {ECO:0000313|EMBL:AUV79080.1, ECO:0000313|Proteomes:UP000236568}; RA Morgan R.D.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|Proteomes:UP000236564, ECO:0000313|Proteomes:UP000236568} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}, and 26695-dRdM2 RC {ECO:0000313|EMBL:AUV79080.1, ECO:0000313|Proteomes:UP000236568}; RA Kumar S., Karmakar B.C., Nagarajan D., Mukhopadhyay A.K., Rao D.N.; RT "N4-cytosine DNA methylation regulates transcription and pathogenesis in RT Helicobacter pylori."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is a component of the acetyl coenzyme A CC carboxylase complex; first, biotin carboxylase catalyzes the CC carboxylation of the carrier protein and then the transcarboxylase CC transfers the carboxyl group to form malonyl-CoA. CC {ECO:0000256|RuleBase:RU364072}. CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC {ECO:0000256|RuleBase:RU364072}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP010436; AJF10208.1; -; Genomic_DNA. DR EMBL; CP026326; AUV77571.1; -; Genomic_DNA. DR EMBL; CP026324; AUV79080.1; -; Genomic_DNA. DR EMBL; MUOT01000002; OOQ12599.1; -; Genomic_DNA. DR RefSeq; WP_001053815.1; NZ_VEYS01000015.1. DR UniPathway; UPA00094; -. DR Proteomes; UP000031529; Chromosome. DR Proteomes; UP000236564; Chromosome. DR Proteomes; UP000236568; Chromosome. DR Proteomes; UP000317384; Unassembled WGS sequence. DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro. DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd06850; biotinyl_domain; 1. DR Gene3D; 2.40.50.100; -; 1. DR InterPro; IPR001249; AcCoA_biotinCC. DR InterPro; IPR050709; Biotin_Carboxyl_Carrier/Decarb. DR InterPro; IPR000089; Biotin_lipoyl. DR InterPro; IPR011053; Single_hybrid_motif. DR NCBIfam; TIGR00531; BCCP; 1. DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1. DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1. DR Pfam; PF00364; Biotin_lipoyl; 1. DR PRINTS; PR01071; ACOABIOTINCC. DR SUPFAM; SSF51230; Single hybrid motif; 1. DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1. PE 4: Predicted; KW Biotin {ECO:0000256|RuleBase:RU364072}; KW Fatty acid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Fatty acid metabolism {ECO:0000256|RuleBase:RU364072}; KW Lipid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Lipid metabolism {ECO:0000256|RuleBase:RU364072}. FT DOMAIN 78..154 FT /note="Lipoyl-binding" FT /evidence="ECO:0000259|PROSITE:PS50968" SQ SEQUENCE 156 AA; 17133 MW; 2F3B860AD53947C5 CRC64; MNLSEIEELI KEFKASDLGH LKLKHEHFEL VLDKESAYAK KSALNPAHSP APIMVEASMP SVQTPVPMVC TPIVDKKEDF VLSPMVGTFY HAPSPGAEPY VKAGDTLKKG QIVGIVEAMK IMNEIEVEYP CKVVSVEVGD AQPVEYGTKL IKVEKL //