ID A0A1A9H0F7_HELPX Unreviewed; 156 AA. AC A0A1A9H0F7; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 13-SEP-2023, entry version 37. DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00017562, ECO:0000256|RuleBase:RU364072}; GN Name=accB {ECO:0000313|EMBL:AUV77571.1}; GN ORFNames=AA971_07385 {ECO:0000313|EMBL:ANH43195.1}, B0X45_00045 GN {ECO:0000313|EMBL:OOQ12599.1}, BB384_06815 GN {ECO:0000313|EMBL:PDW82526.1}, BB423_06655 GN {ECO:0000313|EMBL:PDW36948.1}, C2840_01920 GN {ECO:0000313|EMBL:AUV77571.1}, C2S36_01540 GN {ECO:0000313|EMBL:PUD10761.1}, C2S41_04760 GN {ECO:0000313|EMBL:PUB94738.1}, EC561_05925 GN {ECO:0000313|EMBL:RVZ54228.1}; OS Helicobacter pylori (Campylobacter pylori). OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=210 {ECO:0000313|EMBL:ANH43195.1, ECO:0000313|Proteomes:UP000078100}; RN [1] {ECO:0000313|EMBL:ANH43195.1, ECO:0000313|Proteomes:UP000078100} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=L7 {ECO:0000313|EMBL:ANH43195.1, RC ECO:0000313|Proteomes:UP000078100}; RA Montano V., Didelot X., Foll M., Linz B., Reinhardt R., Suerbaum S., RA Moodley Y., Jensen J.D.; RT "Detecting global and local adaptation in a worldwide sample of RT Helicobacter pylori genomes."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:OOQ12599.1, ECO:0000313|Proteomes:UP000317384} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CC26100 {ECO:0000313|EMBL:OOQ12599.1, RC ECO:0000313|Proteomes:UP000317384}; RX PubMed=28293542; DOI=.3389/fcimb.2017.00050; RA Munoz-Ramirez Z.Y., Mendez-Tenorio A., Kato I., Bravo M.M., Rizzato C., RA Thorell K., Torres R.C., Aviles-Jimenez F., Camorlinga M., Canzian F., RA Torres J.; RT "Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori RT Strains from Latin America Have Followed a Unique Evolution Pathway."; RL Front. Cell. Infect. Microbiol. 7:50-50(2017). RN [3] {ECO:0000313|Proteomes:UP000219848, ECO:0000313|Proteomes:UP000220833} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=22317 {ECO:0000313|EMBL:PDW36948.1, RC ECO:0000313|Proteomes:UP000220833}, and 26100 RC {ECO:0000313|EMBL:PDW82526.1, ECO:0000313|Proteomes:UP000219848}; RX PubMed=28912838; DOI=.1186/s13099-017-0201-1; RA Gutierrez-Escobar A.J., Trujillo E., Acevedo O., Bravo M.M.; RT "Phylogenomics of Colombian Helicobacter pylori isolates."; RL Gut Pathog. 9:52-52(2017). RN [4] {ECO:0000313|Proteomes:UP000244476, ECO:0000313|Proteomes:UP000244849} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=36:3 {ECO:0000313|EMBL:PUD10761.1, RC ECO:0000313|Proteomes:UP000244476}, and 47:5 RC {ECO:0000313|EMBL:PUB94738.1, ECO:0000313|Proteomes:UP000244849}; RA Berthenet E., Yahara K., Thorell K., Pascoe B., Meric G., Mikhail J.M., RA Engstrand L., Enroth H., Burette A., Megraud F., Atherton J., Smith S., RA Wilkinson T.S., Hitchings M.D., Falush D., Sheppard S.K.; RT "Helicobacter pylori genome-wide association study shows promise for RT predicting gastric cancer risk."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AUV77571.1, ECO:0000313|Proteomes:UP000236564} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}; RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AUV77571.1, ECO:0000313|Proteomes:UP000236564} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}; RA Kumar S., Karmakar B.C., Nagarajan D., Mukhopadhyay A.K., Rao D.N.; RT "N4-cytosine DNA methylation regulates transcription and pathogenesis in RT Helicobacter pylori."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:RVZ54228.1, ECO:0000313|Proteomes:UP000288795} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ZH109 {ECO:0000313|EMBL:RVZ54228.1, RC ECO:0000313|Proteomes:UP000288795}; RA Wagner K.; RT "Genetic determinants and prediction of antibiotic resistance phenotypes in RT Helicobacter pylori."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is a component of the acetyl coenzyme A CC carboxylase complex; first, biotin carboxylase catalyzes the CC carboxylation of the carrier protein and then the transcarboxylase CC transfers the carboxyl group to form malonyl-CoA. CC {ECO:0000256|RuleBase:RU364072}. CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC {ECO:0000256|RuleBase:RU364072}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP011482; ANH43195.1; -; Genomic_DNA. DR EMBL; CP026326; AUV77571.1; -; Genomic_DNA. DR EMBL; MUOT01000002; OOQ12599.1; -; Genomic_DNA. DR EMBL; MBGQ01000011; PDW36948.1; -; Genomic_DNA. DR EMBL; MBHV01000011; PDW82526.1; -; Genomic_DNA. DR EMBL; QBPL01000055; PUB94738.1; -; Genomic_DNA. DR EMBL; QBPO01000035; PUD10761.1; -; Genomic_DNA. DR EMBL; RJHV01000015; RVZ54228.1; -; Genomic_DNA. DR RefSeq; WP_001053815.1; NZ_VEYS01000015.1. DR AlphaFoldDB; A0A1A9H0F7; -. DR EnsemblBacteria; ANH43195; ANH43195; AA971_07385. DR EnsemblBacteria; AUV77571; AUV77571; C2840_01920. DR EnsemblBacteria; AUZ23599; AUZ23599; C2844_01915. DR EnsemblBacteria; PDW36948; PDW36948; BB423_06655. DR EnsemblBacteria; PDW82526; PDW82526; BB384_06815. DR EnsemblBacteria; PNL41605; PNL41605; CEP78_004295. DR EnsemblBacteria; PUB94738; PUB94738; C2S41_04760. DR EnsemblBacteria; PUD10761; PUD10761; C2S36_01540. DR PATRIC; fig|1111674.3.peg.1116; -. DR UniPathway; UPA00094; -. DR Proteomes; UP000078100; Chromosome. DR Proteomes; UP000219848; Unassembled WGS sequence. DR Proteomes; UP000220833; Unassembled WGS sequence. DR Proteomes; UP000236564; Chromosome. DR Proteomes; UP000244476; Unassembled WGS sequence. DR Proteomes; UP000244849; Unassembled WGS sequence. DR Proteomes; UP000288795; Unassembled WGS sequence. DR Proteomes; UP000317384; Unassembled WGS sequence. DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro. DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. DR CDD; cd06850; biotinyl_domain; 1. DR Gene3D; 2.40.50.100; -; 1. DR InterPro; IPR001249; AcCoA_biotinCC. DR InterPro; IPR000089; Biotin_lipoyl. DR InterPro; IPR011053; Single_hybrid_motif. DR NCBIfam; TIGR00531; BCCP; 1. DR PANTHER; PTHR45266; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1. DR PANTHER; PTHR45266:SF3; OXALOACETATE DECARBOXYLASE ALPHA CHAIN; 1. DR Pfam; PF00364; Biotin_lipoyl; 1. DR PRINTS; PR01071; ACOABIOTINCC. DR SUPFAM; SSF51230; Single hybrid motif; 1. DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1. PE 4: Predicted; KW Biotin {ECO:0000256|RuleBase:RU364072}; KW Fatty acid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Fatty acid metabolism {ECO:0000256|RuleBase:RU364072}; KW Lipid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Lipid metabolism {ECO:0000256|RuleBase:RU364072}. FT DOMAIN 78..154 FT /note="Lipoyl-binding" FT /evidence="ECO:0000259|PROSITE:PS50968" SQ SEQUENCE 156 AA; 17133 MW; 2F3B860AD53947C5 CRC64; MNLSEIEELI KEFKASDLGH LKLKHEHFEL VLDKESAYAK KSALNPAHSP APIMVEASMP SVQTPVPMVC TPIVDKKEDF VLSPMVGTFY HAPSPGAEPY VKAGDTLKKG QIVGIVEAMK IMNEIEVEYP CKVVSVEVGD AQPVEYGTKL IKVEKL //