ID A0A1A9H0F7_HELPX Unreviewed; 156 AA. AC A0A1A9H0F7; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 18-JUL-2018, entry version 16. DE RecName: Full=Biotin carboxyl carrier protein of acetyl-CoA carboxylase {ECO:0000256|RuleBase:RU364072}; GN Name=accB {ECO:0000313|EMBL:AUV77571.1}; GN ORFNames=AA971_07385 {ECO:0000313|EMBL:ANH43195.1}, BB384_06815 GN {ECO:0000313|EMBL:PDW82526.1}, BB423_06655 GN {ECO:0000313|EMBL:PDW36948.1}, C2840_01920 GN {ECO:0000313|EMBL:AUV77571.1}, C2844_01915 GN {ECO:0000313|EMBL:AUZ23599.1}, C2S36_01540 GN {ECO:0000313|EMBL:PUD10761.1}, C2S41_04760 GN {ECO:0000313|EMBL:PUB94738.1}, CEP78_004295 GN {ECO:0000313|EMBL:PNL41605.1}; OS Helicobacter pylori (Campylobacter pylori). OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=210 {ECO:0000313|EMBL:ANH43195.1, ECO:0000313|Proteomes:UP000078100}; RN [1] {ECO:0000313|EMBL:ANH43195.1, ECO:0000313|Proteomes:UP000078100} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=L7 {ECO:0000313|EMBL:ANH43195.1, RC ECO:0000313|Proteomes:UP000078100}; RA Montano V., Didelot X., Foll M., Linz B., Reinhardt R., Suerbaum S., RA Moodley Y., Jensen J.D.; RT "Detecting global and local adaptation in a worldwide sample of RT Helicobacter pylori genomes."; RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:PDW36948.1, ECO:0000313|Proteomes:UP000219848, ECO:0000313|Proteomes:UP000220833} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=22317 {ECO:0000313|EMBL:PDW36948.1, RC ECO:0000313|Proteomes:UP000220833}, and 26100 RC {ECO:0000313|EMBL:PDW82526.1, ECO:0000313|Proteomes:UP000219848}; RX PubMed=28912838; DOI=.1186/s13099-017-0201-1; RA Gutierrez-Escobar A.J., Trujillo E., Acevedo O., Bravo M.M.; RT "Phylogenomics of Colombian Helicobacter pylori isolates."; RL Gut Pathog 9:52-52(2017). RN [3] {ECO:0000313|EMBL:PNL41605.1, ECO:0000313|Proteomes:UP000198044} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=FDAARGOS_299 {ECO:0000313|EMBL:PNL41605.1, RC ECO:0000313|Proteomes:UP000198044}; RA Goldberg B., Campos J., Tallon L., Sadzewicz L., Sengamalay N., RA Ott S., Godinez A., Nagaraj S., Vyas G., Aluvathingal J., Nadendla S., RA Geyer C., Sichtig H.; RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS): RT Supporting development and validation of Infectious Disease Dx RT tests."; RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:PUB94738.1, ECO:0000313|Proteomes:UP000244476, ECO:0000313|Proteomes:UP000244849} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=36:3 {ECO:0000313|EMBL:PUD10761.1, RC ECO:0000313|Proteomes:UP000244476}, and 47:5 RC {ECO:0000313|EMBL:PUB94738.1, ECO:0000313|Proteomes:UP000244849}; RA Berthenet E., Yahara K., Thorell K., Pascoe B., Meric G., RA Mikhail J.M., Engstrand L., Enroth H., Burette A., Megraud F., RA Atherton J., Smith S., Wilkinson T.S., Hitchings M.D., Falush D., RA Sheppard S.K.; RT "Helicobacter pylori genome-wide association study shows promise for RT predicting gastric cancer risk."; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:AUV77571.1, ECO:0000313|Proteomes:UP000236564, ECO:0000313|Proteomes:UP000239200} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}, dRdM2addM2 RC {ECO:0000313|Proteomes:UP000239200}, and DRdM2addM2 RC {ECO:0000313|EMBL:AUZ23599.1}; RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.; RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:AUV77571.1, ECO:0000313|Proteomes:UP000236564, ECO:0000313|Proteomes:UP000239200} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=26695-dR {ECO:0000313|EMBL:AUV77571.1, RC ECO:0000313|Proteomes:UP000236564}, dRdM2addM2 RC {ECO:0000313|Proteomes:UP000239200}, and DRdM2addM2 RC {ECO:0000313|EMBL:AUZ23599.1}; RA Kumar S., Karmakar B.C., Nagarajan D., Mukhopadhyay A.K., Rao D.N.; RT "N4-cytosine DNA methylation regulates transcription and pathogenesis RT in Helicobacter pylori."; RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is a component of the acetyl coenzyme A CC carboxylase complex; first, biotin carboxylase catalyzes the CC carboxylation of the carrier protein and then the transcarboxylase CC transfers the carboxyl group to form malonyl-CoA. CC {ECO:0000256|RuleBase:RU364072}. CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis. CC {ECO:0000256|RuleBase:RU364072}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP011482; ANH43195.1; -; Genomic_DNA. DR EMBL; CP026326; AUV77571.1; -; Genomic_DNA. DR EMBL; CP026515; AUZ23599.1; -; Genomic_DNA. DR EMBL; MBGQ01000011; PDW36948.1; -; Genomic_DNA. DR EMBL; MBHV01000011; PDW82526.1; -; Genomic_DNA. DR EMBL; NJFC02000001; PNL41605.1; -; Genomic_DNA. DR EMBL; QBPL01000055; PUB94738.1; -; Genomic_DNA. DR EMBL; QBPO01000035; PUD10761.1; -; Genomic_DNA. DR RefSeq; WP_001053815.1; NZ_QBPO01000035.1. DR ProteinModelPortal; A0A1A9H0F7; -. DR EnsemblBacteria; ANH43195; ANH43195; AA971_07385. DR PATRIC; fig|1111674.3.peg.1116; -. DR UniPathway; UPA00094; -. DR Proteomes; UP000078100; Chromosome. DR Proteomes; UP000198044; Unassembled WGS sequence. DR Proteomes; UP000219848; Unassembled WGS sequence. DR Proteomes; UP000220833; Unassembled WGS sequence. DR Proteomes; UP000236564; Chromosome. DR Proteomes; UP000239200; Chromosome. DR Proteomes; UP000244476; Unassembled WGS sequence. DR Proteomes; UP000244849; Unassembled WGS sequence. DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro. DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro. DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR001249; AcCoA_biotinCC. DR InterPro; IPR000089; Biotin_lipoyl. DR InterPro; IPR011053; Single_hybrid_motif. DR Pfam; PF00364; Biotin_lipoyl; 1. DR PRINTS; PR01071; ACOABIOTINCC. DR SUPFAM; SSF51230; SSF51230; 1. DR TIGRFAMs; TIGR00531; BCCP; 1. DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1. PE 4: Predicted; KW Biotin {ECO:0000256|RuleBase:RU364072}; KW Complete proteome {ECO:0000313|Proteomes:UP000078100, KW ECO:0000313|Proteomes:UP000198044, ECO:0000313|Proteomes:UP000219848, KW ECO:0000313|Proteomes:UP000220833}; KW Fatty acid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Fatty acid metabolism {ECO:0000256|RuleBase:RU364072}; KW Lipid biosynthesis {ECO:0000256|RuleBase:RU364072}; KW Lipid metabolism {ECO:0000256|RuleBase:RU364072}. FT DOMAIN 78 154 Lipoyl-binding. {ECO:0000259|PROSITE: FT PS50968}. SQ SEQUENCE 156 AA; 17133 MW; 2F3B860AD53947C5 CRC64; MNLSEIEELI KEFKASDLGH LKLKHEHFEL VLDKESAYAK KSALNPAHSP APIMVEASMP SVQTPVPMVC TPIVDKKEDF VLSPMVGTFY HAPSPGAEPY VKAGDTLKKG QIVGIVEAMK IMNEIEVEYP CKVVSVEVGD AQPVEYGTKL IKVEKL //