ID A0A1A8WZJ6_9APIC Unreviewed; 337 AA. AC A0A1A8WZJ6; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 18-SEP-2019, entry version 20. DE RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase {ECO:0000256|RuleBase:RU361160}; DE EC=1.2.1.12 {ECO:0000256|RuleBase:RU361160}; GN ORFNames=POVCU1_034250 {ECO:0000313|EMBL:SBS96851.1}; OS Plasmodium ovale curtisi. OC Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium). OX NCBI_TaxID=864141 {ECO:0000313|EMBL:SBS96851.1}; RN [1] {ECO:0000313|EMBL:SBS96851.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Lavstsen T., Jespersen J.S.; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)- CC 3-phospho-glyceroyl phosphate + H(+) + NADH; CC Xref=Rhea:RHEA:10300, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57604, ChEBI:CHEBI:57945, CC ChEBI:CHEBI:59776; EC=1.2.1.12; CC Evidence={ECO:0000256|RuleBase:RU361160}; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D- CC glyceraldehyde 3-phosphate: step 1/5. CC {ECO:0000256|RuleBase:RU361160}. CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU361160}. CC -!- SIMILARITY: Belongs to the glyceraldehyde-3-phosphate CC dehydrogenase family. {ECO:0000256|RuleBase:RU000397}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; FLQV01000632; SBS96851.1; -; Genomic_DNA. DR UniPathway; UPA00109; UER00184. DR GO; GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; IEA:UniProtKB-UniRule. DR GO; GO:0051287; F:NAD binding; IEA:UniProtKB-UniRule. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR GO; GO:0006006; P:glucose metabolic process; IEA:InterPro. DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway. DR InterPro; IPR020831; GlycerAld/Erythrose_P_DH. DR InterPro; IPR020830; GlycerAld_3-P_DH_AS. DR InterPro; IPR020829; GlycerAld_3-P_DH_cat. DR InterPro; IPR020828; GlycerAld_3-P_DH_NAD(P)-bd. DR InterPro; IPR006424; Glyceraldehyde-3-P_DH_1. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR PANTHER; PTHR10836; PTHR10836; 1. DR Pfam; PF02800; Gp_dh_C; 1. DR Pfam; PF00044; Gp_dh_N; 1. DR PIRSF; PIRSF000149; GAP_DH; 1. DR PRINTS; PR00078; G3PDHDRGNASE. DR SMART; SM00846; Gp_dh_N; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR TIGRFAMs; TIGR01534; GAPDH-I; 1. DR PROSITE; PS00071; GAPDH; 1. PE 3: Inferred from homology; KW Glycolysis {ECO:0000256|RuleBase:RU361160}; KW NAD {ECO:0000256|PIRSR:PIRSR000149-3, ECO:0000256|RuleBase:RU361160}; KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000149-3}; KW Oxidoreductase {ECO:0000256|RuleBase:RU361160}. FT DOMAIN 4 153 Gp_dh_N. {ECO:0000259|SMART:SM00846}. FT NP_BIND 13 14 NAD. {ECO:0000256|PIRSR:PIRSR000149-3}. FT REGION 152 154 Glyceraldehyde 3-phosphate binding. FT {ECO:0000256|PIRSR:PIRSR000149-2}. FT REGION 214 215 Glyceraldehyde 3-phosphate binding. FT {ECO:0000256|PIRSR:PIRSR000149-2}. FT ACT_SITE 153 153 Nucleophile. {ECO:0000256|PIRSR: FT PIRSR000149-1}. FT BINDING 35 35 NAD. {ECO:0000256|PIRSR:PIRSR000149-3}. FT BINDING 122 122 NAD. {ECO:0000256|PIRSR:PIRSR000149-3}. FT BINDING 183 183 Glyceraldehyde 3-phosphate. FT {ECO:0000256|PIRSR:PIRSR000149-2}. FT BINDING 237 237 Glyceraldehyde 3-phosphate. FT {ECO:0000256|PIRSR:PIRSR000149-2}. FT BINDING 319 319 NAD. {ECO:0000256|PIRSR:PIRSR000149-3}. FT SITE 180 180 Activates thiol group during catalysis. FT {ECO:0000256|PIRSR:PIRSR000149-4}. SQ SEQUENCE 337 AA; 36587 MW; FAA2CE8AB6763AB2 CRC64; MTVTKVGING FGRIGRLVFR AAYERSDIEV VAINDPFMDI KHLCYLLKYD SVHGKFPCEV TPGEGMFTVG DKKIYVHSEK DPAQIPWGKY AIDVVCESTG VFLTKELAGA HLKGGAKKVI MSAPPKDDTP IYVMGINHQK YDGKQLIVSN ASCTTNCLAP IAKVLNDNFG IVEGLMTTVH ASTANQLVVD GPSKGGKDWR AGRCALQNII PASTGAAKAV GKVLPELNGK LTGVAFRVPI GTVSVVDLVC RLEKPAKYEE VAAQIKKAAD GPLKGILGYT EDEVVSQDFV HDNRSSIFDL KAGLALNDNF FKIVSWYDNE WGYSNRVLDL AVHITKN //