ID   A0A194Q6J6_PAPXU        Unreviewed;       651 AA.
AC   A0A194Q6J6;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   23-MAY-2018, entry version 7.
DE   RecName: Full=DNA-(apurinic or apyrimidinic site) lyase {ECO:0000256|RuleBase:RU362131};
DE            EC=4.2.99.18 {ECO:0000256|RuleBase:RU362131};
GN   ORFNames=RR46_05264 {ECO:0000313|EMBL:KPJ00999.1};
OS   Papilio xuthus (Asian swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Papilionoidea; Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ00999.1, ECO:0000313|Proteomes:UP000053268};
RN   [1] {ECO:0000313|EMBL:KPJ00999.1, ECO:0000313|Proteomes:UP000053268}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ00999.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ00999.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y.,
RA   Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G.,
RA   Kronforst M.R., Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in
RT   butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|RuleBase:RU362131};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|RuleBase:RU362131};
CC       Note=Probably binds two magnesium or manganese ions per subunit.
CC       {ECO:0000256|RuleBase:RU362131};
CC   -!- SIMILARITY: Belongs to the DNA repair enzymes AP/ExoA family.
CC       {ECO:0000256|RuleBase:RU362131}.
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DR   EMBL; KQ459439; KPJ00999.1; -; Genomic_DNA.
DR   Proteomes; UP000053268; Unassembled WGS sequence.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR004808; AP_endonuc_1.
DR   InterPro; IPR020847; AP_endonuclease_F1_BS.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   PANTHER; PTHR22748; PTHR22748; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   TIGRFAMs; TIGR00633; xth; 1.
DR   PROSITE; PS00726; AP_NUCLEASE_F1_1; 1.
DR   PROSITE; PS51435; AP_NUCLEASE_F1_4; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053268};
KW   DNA damage {ECO:0000256|RuleBase:RU362131};
KW   DNA repair {ECO:0000256|RuleBase:RU362131};
KW   Lyase {ECO:0000256|RuleBase:RU362131};
KW   Magnesium {ECO:0000256|RuleBase:RU362131};
KW   Metal-binding {ECO:0000256|RuleBase:RU362131};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053268}.
FT   DOMAIN      394    634       Endo/exonuclease/phosphatase.
FT                                {ECO:0000259|Pfam:PF03372}.
FT   COILED      319    339       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   651 AA;  73106 MW;  863FC8F0ECAD36A3 CRC64;
     MAPRSAKGKK AADVKVAESA PAKKGRKGKQ VAEPEPTEAE EVKTTVVEKK TKRGKKAKDE
     EIINGDNEEV CPPAKKSKKK ISEDKAEEQS NGDNSSPEEE PNLDEQNEGG DDESETNGHT
     EEAKPAGGRG RKKQTKKETV PENKPKETGR GRKNAKQEVQ EDVAKNSEVV EEKPKPSGRG
     RGKKAQAKPS NDLEEEDKAE SVEEEVKPEP PATKGKKKQN KGSKEKIETD AAMSDQEKEE
     EDIVEEEPKK KETKSRKNQG KKAQPKEQED KEEDIVEDTQ TTKKRRGAKK DDKSKDSKEE
     EEVEEKAPEV KPAKGKRGAK NAAAKAAEAE QDIQDTGESN NKRRRKAADD KAGAEDSKKK
     APAKNKTATK YEDIDFSSDS KTSQGKDWNF KISSWNVDGI RAWMDKGGLE YIQYEKPDIL
     CLQEIKCSKE KLPEPIKNVP GYHAYWLCSE QDGYAGVGIY TTKLAMNVQY GLQDEELDSE
     GRIITAEYEQ FYLICTYVPN AGRKLVTLPK RLKWNEEFRK HVKSLDKKKP VIICGDMNVS
     HNEIDLANPK TNRKNAGFTE EERTGMTELL GDGFVDTYRL LYPDKTSAYT FWTYMFNCRA
     KNVGWRLDYF IVSERLVTSV CDSIIRDSVY GSDHCPVTLL LHLSSADKPK E
//