ID A0A194PGG9_PAPXU Unreviewed; 2211 AA. AC A0A194PGG9; DT 05-OCT-2016, integrated into UniProtKB/TrEMBL. DT 05-OCT-2016, sequence version 1. DT 16-OCT-2019, entry version 18. DE SubName: Full=Sortilin-related receptor {ECO:0000313|EMBL:KPI92486.1}; GN ORFNames=RR46_13707 {ECO:0000313|EMBL:KPI92486.1}; OS Papilio xuthus (Asian swallowtail butterfly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; OC Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia; OC Papilionoidea; Papilionidae; Papilioninae; Papilio. OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPI92486.1, ECO:0000313|Proteomes:UP000053268}; RN [1] {ECO:0000313|EMBL:KPI92486.1, ECO:0000313|Proteomes:UP000053268} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPI92486.1}; RC TISSUE=Whole body {ECO:0000313|EMBL:KPI92486.1}; RX PubMed=26354079; DOI=10.1038/ncomms9212; RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L., RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., RA Jiang X., Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., RA Kronforst M.R., Wang W.; RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in RT butterflies."; RL Nat. Commun. 6:8212-8212(2015). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KQ459604; KPI92486.1; -; Genomic_DNA. DR Proteomes; UP000053268; Unassembled WGS sequence. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR CDD; cd00063; FN3; 3. DR CDD; cd00112; LDLa; 9. DR Gene3D; 2.120.10.30; -; 1. DR Gene3D; 2.60.40.10; -; 3. DR Gene3D; 4.10.400.10; -; 9. DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR036055; LDL_receptor-like_sf. DR InterPro; IPR023415; LDLR_class-A_CS. DR InterPro; IPR000033; LDLR_classB_rpt. DR InterPro; IPR002172; LDrepeatLR_classA_rpt. DR InterPro; IPR031777; Sortilin_C. DR InterPro; IPR031778; Sortilin_N. DR InterPro; IPR006581; VPS10. DR Pfam; PF00041; fn3; 1. DR Pfam; PF00057; Ldl_recept_a; 9. DR Pfam; PF00058; Ldl_recept_b; 2. DR Pfam; PF15902; Sortilin-Vps10; 2. DR Pfam; PF15901; Sortilin_C; 1. DR PRINTS; PR00261; LDLRECEPTOR. DR SMART; SM00181; EGF; 3. DR SMART; SM00060; FN3; 5. DR SMART; SM00192; LDLa; 9. DR SMART; SM00135; LY; 5. DR SMART; SM00602; VPS10; 1. DR SUPFAM; SSF49265; SSF49265; 2. DR SUPFAM; SSF57424; SSF57424; 9. DR PROSITE; PS50853; FN3; 4. DR PROSITE; PS01209; LDLRA_1; 2. DR PROSITE; PS50068; LDLRA_2; 9. DR PROSITE; PS51120; LDLRB; 6. PE 4: Predicted; KW Complete proteome {ECO:0000313|Proteomes:UP000053268}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124, KW ECO:0000256|SAAS:SAAS00895822}; KW EGF-like domain {ECO:0000256|SAAS:SAAS00450137}; KW Golgi apparatus {ECO:0000256|SAAS:SAAS00889894}; KW Membrane {ECO:0000256|SAAS:SAAS00311924, ECO:0000256|SAM:Phobius}; KW Receptor {ECO:0000256|SAAS:SAAS00889889, ECO:0000313|EMBL:KPI92486.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000053268}; KW Repeat {ECO:0000256|SAAS:SAAS00998998}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00311912, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00311918, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00889924}. FT SIGNAL 1 24 {ECO:0000256|SAM:SignalP}. FT CHAIN 25 2211 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5008263225. FT TRANSMEM 2137 2161 Helical. {ECO:0000256|SAM:Phobius}. FT REPEAT 178 195 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 839 882 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 883 930 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 931 976 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 977 1021 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT REPEAT 1022 1062 LDL-receptor class B. FT {ECO:0000256|PROSITE-ProRule:PRU00461}. FT DOMAIN 1638 1735 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1740 1827 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1829 1928 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 2027 2128 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT REGION 2182 2211 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COMPBIAS 2182 2198 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT DISULFID 1126 1138 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1133 1151 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1145 1160 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1162 1174 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1169 1187 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1181 1196 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1201 1213 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1208 1226 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1220 1235 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1291 1303 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1298 1316 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1353 1365 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1360 1378 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1372 1387 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1407 1419 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1414 1432 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1426 1441 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1455 1467 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1462 1480 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1474 1489 {ECO:0000256|PROSITE-ProRule:PRU00124}. FT DISULFID 1520 1535 {ECO:0000256|PROSITE-ProRule:PRU00124}. SQ SEQUENCE 2211 AA; 248390 MW; 3620AF0AA8C2A8F1 CRC64; MFTVIRRRIS FVALLYFIPC VVSSHEYETW EKSLYVAQEP FEGSGKLFII NKFDTVGDGS HFERKKREAP TTPAPALEKN ISTWTTHLND SHQQLMVHWV GEGSKVIICL ARDSSPRSNG TLSPSALFIS YNYGQTIVNK TESFRLDDTP NSGYAQLDRF YNHPKHPEFC VFVDSINKRL YYTDDNGQNI HRSELTFHPS ELLFDEDNPK RFVVLDKVGR NRMLYMTFNG GKTFTLIQSY VKTFYWSSGP GFPKMFYLER WEPNRSSTVL SVSDPEDMIN AKVLFADAKE FQIKGDYMFA MRQKDNNTFD LYISHQRGPF YKAEFQTELD RRKFHIADVT DKRIFISVMH TENLTNLYVS EISNNFTQYN FVLSLEQVLC YFPQGNWKDS WLEDVTDDAF TDLYRVEGLK GIYIASKVNS KSLIADIEPE HLVSLITFDH GVTWSPIKPP AEDENGKPLS CIDSNDSEKS CSLHLCQKFS QLYPVTSPPG NVISNAMRLL CIAALAAVKR VGGLRVKHVT WNLQVVGSNP AISASIMSSK SAPGIIMATG VVGRSLKGIP GVYLSRVAGL TWKRILKDFY FFNYGDHGGV LVAVKYFKML SETREILYST NEGIEWNSYQ FNANDLRIYG LMTEPGENTT VFTMFGSANE QHQWIIITID LQKAFPRNCT ADDYKDWSPS PPDTTATCVL GTRDVFQRRL AHTNCYNGID YDGPIRKEVC ECGRRDFECD FGFVLSRNVC VHNKSSKYDP YSIPPSCRPG DYYERTKGYR KIDGDVCTTS GYLPYNPDVI PCPLDEPTEF LLVALRDKIA RIDLSDNTTI FPIKDQQNIV AIEFDMKNNC IYWADIEVDK ISRQCFETGF VQEVVVDTDL ASIEGMALDW ISNVLFFVDG MRKKIEAVRT DLSSEGRMRV TILGPDVLSK PRGIVVHPKA GYLFWTDWDR NNPSVSRSNL DGSHIVRLFE KPIVQWPNGI TIDQMSERIY WVDAMEDYIA SADLNGQYFK KILVNDEKVS HPFAVAVLKD KMYWDDWKAK SIFIADKDNG QNVITINGSF SGLMGLKVFA HFIQHGSNAC SYKNTSCDAL CLGGPGNSFS CLCPDGFVKS HGKCLCPNLV EPYANLTCPK KPGATCASDQ FSCKNDMCIA QSWRCDGNDD CGDGSDEAGC VCAPPRVACD NGSCYLPQWR CDGDIDCSDM TDEKDCGKHN CSENEFQCGN GNCVDKRWVC DGDNDCKDDS DERNCTSQVK RPNTQVNCSV HSFACNDSSG MCIPNSWVCD NETDCPGGED ERDERCRNST CAPYMFRCPS GKCIYKSWVC DGENDCSDVE SSDEKNCTHI GHSKLLPRPT TESPFSFPAN SSCLDWMIQC DNGNCLPYWW RCDGINDCGD NSDEVACGVH FVEPKTINRA DSVRQKCGKT RFTCSPGVCI PLSWVCDSQE DCVDGSDEHS CRAWATATPL PLPSCGALET TCRDGGCVLT AKICDGVPDC VDHSDETHCT MKASKPSGAC PGDQFECDEG TRCVWRGALC DGRQDCYDGS DETNCSSHEH NYHYVSLGVD QSSINSTSFL VSCWLAQQQR VLYSFLPSIA KVSDGIWRNM TWTTDSVYRF TGLEPYTNYN VTFYIRDSKS NKTYPSMKYV NTTTGEGVPS PPLRVSVRQM IGSRVNVIWD PPASPRGRLR RYTLYYAPPL PPAQKVVFVT HHEPVSLTVR GYFKPNTNYS FWVTATNNAY TSNSSEVMYL TFDEVGDVDD LKNISVTRLA NNSVSVKWDK IRSVDGYIVS TQLPLLYSRL QPIRTKENNV TLKNLPPGVK IFIHVMAYKG SMIGEPVTEV IITEGERDEM LNMTAILLKE KRTAVLLSWS PPLADRYNGK ELKYQVIYTD AAHWRIPTDL KEDHEKKIIT TNTSVVIDGL HACETYVFTV SLLGGPVTKY KEIVTRENPK APIKDLDYEY NKEKSELKIK WHINCNALSE AVPYRLEITE LTHNKVSRYA LNATRNSSLE HIIENVPVGG RFNICVAAHV EGASKRCIDV RTGALPAPRG LVAWLAPNGH LVLNWQHVEG PDTPKHKYQV IVSEKEIPDD LVQPSADMRV EEAERSPLLL AVTAPAAARP LYVSVRAVTH DGYYSELSEV NTLTMEDSVE EMGTASAVWW GCGAAVVGVA ALGAALLYSV VRQRRLARSF LRLSAHTPRY DSRRGQATIE HDDDDVPPIQ GFSDDEPLVI A //