ID A0A183Q5T1_9TREM Unreviewed; 235 AA. AC A0A183Q5T1; DT 07-SEP-2016, integrated into UniProtKB/TrEMBL. DT 07-SEP-2016, sequence version 1. DT 03-MAY-2023, entry version 20. DE RecName: Full=Insulin-induced gene 1 protein {ECO:0000256|Google:ProtNLM}; OS Schistosoma mattheei. OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma. OX NCBI_TaxID=31246 {ECO:0000313|Proteomes:UP000050791, ECO:0000313|WBParaSite:SMTD_0002196601-mRNA-1}; RN [1] {ECO:0000313|WBParaSite:SMTD_0002196601-mRNA-1} RP IDENTIFICATION. RG WormBaseParasite; RL Submitted (JUN-2016) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004477}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A183Q5T1; -. DR STRING; 31246.A0A183Q5T1; -. DR WBParaSite; SMTD_0002196601-mRNA-1; SMTD_0002196601-mRNA-1; SMTD_0002196601. DR Proteomes; UP000050791; Unplaced. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301:SF12; INSILUN INDUCED PROTEIN; 1. DR PANTHER; PTHR15301; INSULIN-INDUCED GENE 1; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023221}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 43..63 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 83..101 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 144..162 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 168..188 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 200..222 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 235 AA; 26393 MW; 1113DF1DCB46B7C0 CRC64; MALNLLNLSL LVLLHHSIRN QLITRLSRAM VLLLQTTKFP VLVYRGLLLF FLGICFCWVS EALHNIKGEF TASKISFYTE SAAKFWISFC CGVASVTVGL LSPCVDSKLG AFDAYNKEWS SVLRCAALFF GFSHATARID FATYSQLSLT ALGLSIALWW VFDRSLVGFV FGMAVALLAT FIFQSFVWKQ LYRYSHPMMA AWLPCLFFSG GVVIVLVGRQ LAKPDVMELM QRKVK //