ID   A0A180A6U5_LACRH        Unreviewed;       839 AA.
AC   A0A180A6U5;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=galactosylceramidase {ECO:0000256|ARBA:ARBA00012657};
DE            EC=3.2.1.46 {ECO:0000256|ARBA:ARBA00012657};
DE   AltName: Full=Galactosylceramidase {ECO:0000256|ARBA:ARBA00033098};
GN   ORFNames=CCE29_06885 {ECO:0000313|EMBL:ART95700.1}, FOS38_05830
GN   {ECO:0000313|EMBL:MBB1164459.1}, GFB59_00325
GN   {ECO:0000313|EMBL:QPB46449.1};
OS   Lacticaseibacillus rhamnosus (Lactobacillus rhamnosus).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lacticaseibacillus.
OX   NCBI_TaxID=47715 {ECO:0000313|EMBL:QPB46449.1, ECO:0000313|Proteomes:UP000663681};
RN   [1] {ECO:0000313|EMBL:ART95700.1, ECO:0000313|Proteomes:UP000195731}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4B15 {ECO:0000313|EMBL:ART95700.1,
RC   ECO:0000313|Proteomes:UP000195731};
RA   Oh N.-S.;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:MBB1164459.1, ECO:0000313|Proteomes:UP000551634}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DPC 7102 {ECO:0000313|EMBL:MBB1164459.1,
RC   ECO:0000313|Proteomes:UP000551634};
RA   Leeuwendaal N., Stanton C., O'Toole P.W., Beresford T.;
RT   "Annotated Genomes of Lactobacillus rhamnosus DPC 7102 and Lactobacillus
RT   paracasei DCP 7150.";
RL   Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:QPB46449.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TK-F8B {ECO:0000313|EMBL:QPB46449.1};
RA   Chen H.;
RT   "Whole genome of Lactobacillus rhamnosus TK-F8B.";
RL   Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 59 family.
CC       {ECO:0000256|ARBA:ARBA00005637}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP021426; ART95700.1; -; Genomic_DNA.
DR   EMBL; VLHP01000005; MBB1164459.1; -; Genomic_DNA.
DR   EMBL; CP045586; QPB46449.1; -; Genomic_DNA.
DR   RefSeq; WP_014568910.1; NZ_WKOZ01000004.1.
DR   Proteomes; UP000195731; Chromosome.
DR   Proteomes; UP000551634; Unassembled WGS sequence.
DR   Proteomes; UP000663681; Chromosome.
DR   GO; GO:0004336; F:galactosylceramidase activity; IEA:InterPro.
DR   GO; GO:0006683; P:galactosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR049161; GH59_cat.
DR   InterPro; IPR001286; Glyco_hydro_59.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR15172; GALACTOCEREBROSIDASE; 1.
DR   PANTHER; PTHR15172:SF1; GALACTOCEREBROSIDASE; 1.
DR   Pfam; PF02057; Glyco_hydro_59; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE   3: Inferred from homology;
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
FT   DOMAIN          22..361
FT                   /note="Glycosyl hydrolase family 59 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02057"
SQ   SEQUENCE   839 AA;  92976 MW;  7439A784F6859C5E CRC64;
     MHTLTIDGSQ LQLEQNEANT IKGFGLLSCN NTSRLLMDYK WEQPEVYQQV LQHLFGGQQP
     LMRMLKVELG SDSNTSCGTE PAPQRAADEP ANVARGMGFQ LIADAKKIQP DLKTCMLRWA
     EPGFLRPSWR QVKSDDPDEK VPTEAFEAMY QYYKQTVIAA WQAYGYLFDY IDPDRNETKH
     PMYRYLKWFA NRLKTDQADF PEGFPVADYH AIKLITSDQN YGTDMGTALL NDPELQAVIP
     AVGYHYNTDD GPDKPFTKIA DQLHKEVWYS EGIAPVTFGT LRTQDTTGIG IGGPMSALDV
     ANRLVKSYAR SRRSLYIFQP AIGGLYPGAK YPGKQLLEMD TPWSGYFQQD TVALAVMHHF
     TDFAVTGWRD QTAAKNWRYV PSATVSEVAG TENLTQAFGA ASVMTLVAPD ETDYTVMLIN
     DTSAPQTYQI TVKNLAAATK PLYVWQTWAD DAGKIHDREK TTTLTPVNGN VTVTIEPRAI
     ISATTTDFQP QALLPNPDVK TDQPLQQDPE NHVLFHDDYT YADMPADYLT RRGGTPKYTT
     DMDGAFEVVE QDGKRGLQQK ITEQSRALAW ETQTDPNFTV GDIRWLNYAA ALKFTFDTTT
     RQNTVSANYI GLGVRSVDDF EGSLFSAPYV ATLTVGGKLR FYVRGALAAT LDVPVFDAEV
     SHELIVEATD RHVTVQIDGQ TYVTYDDPSD QPGLAGQVKV GTGYFKTVIQ ALTVTSTSAP
     AVLGHRRDDL DASLTFSDDQ WERLAARFPH AWERSQSIGE KGATVDFDVE GTGFVLFGTQ
     AHASRLQLAV DGRIQEVVPL TALAKQPNTV VTDLAAGPHH VKVTVIDGSY TFDGVAPIL
//